The Endocrine Society’s annual meeting, ENDO 2024, was held from June 1-4 in Boston, MA. This event served as a leading gathering for professionals in the field of endocrinology. The conference showcased esteemed experts and influential thought leaders who provided insightful presentations on cutting-edge research, treatments, and developments in endocrine disorders.

Highlighted below are some of the significant studies presented at ENDO 2024 that focused on diabetes, encompassing both type 1 and type 2 diabetes.

Use of Telemedicine in Diabetes Self-Management Education (DSME) of Patients with Type 2 Diabetes Mellitus at the University of Santo Tomas Hospital: A Randomized Controlled Trial

  • This study investigated the effectiveness of Diabetes Self-Management Education (DSME) delivered through telemedicine compared to traditional face-to-face encounters. The primary objective was to assess whether DSME via telemedicine can achieve similar outcomes in improving diabetes knowledge and promoting adherence to self-care practices.
  • The study demonstrated that DSME delivered through telemedicine resulted in improved glycemic control, increased diabetes knowledge, and enhanced adherence to self-care behaviors. Telemedicine offers a valuable solution for reaching patients with Type 2 Diabetes Mellitus (T2DM) who may face barriers to accessing traditional healthcare services.

Effect Of The SARS-CoV-2 Pandemic on Metabolic Control In Patients With Type 2 Diabetes: A 5-year Cohort Follow-Up

  • The study compared the metabolic control of patients with Type 2 Diabetes Mellitus (T2DM) before and during the 3-year duration of the COVID pandemic. Additionally, the researchers analyzed the types of consultations and attendance trends across various specialties, as well as the number of medications prescribed to patients before and during the pandemic.
  • During the pandemic, there was a higher proportion of patients who achieved controlled glycemic and diastolic pressure targets. This improvement can be attributed to patients’ increased access to telemedicine and the collaboration of a multidisciplinary team.

Diabetes Mellitus Is Associated With Lower Fracture Risk: A US Population Survey 

  • Diabetes Mellitus (DM) is linked to a higher risk of fractures, which is believed to be due to decreased bone mineral density resulting from inadequate glycemic control. However, the relationship between glucose metabolism status and fracture risk remains uncertain. This study aims to examine and compare fracture rates among individuals in different glucose tolerance states within a representative sample of the US population.
  • The study found a decreased risk of fractures in individuals with diabetes mellitus (DM) compared to those with normal glucose tolerance (NGT), with the exception of spine fractures. While the specific type of diabetes was not specified in the NHANES data, it is estimated that over 90% of cases are type 2 diabetes.

Demographic Characteristics Of Patients With Prediabetes Who Reverted To Normoglycemia Or Progressed To Diabetes At 1 Year Follow Up 

  • The study investigated the relationships between age, race, gender, and BMI in individuals with pre-diabetes who either developed type 2 diabetes or returned to normal blood sugar levels (normoglycemia) within a one-year follow-up period.
  • The research results highlight the substantial racial disparities and gender variations in the regression to normoglycemia and progression to diabetes. This underscores the importance of implementing personalized interventions and targeted strategies for individuals with prediabetes to prevent the development of Type 2 Diabetes and to attain normoglycemia.

The Effect of intermittent very low-calorie diet on the levels of angiopoietin-like protein 2 and angiopoietin-like protein 6 in obese patients with type 2 diabetes 

  • This study assessed the alterations in ANGPTL2 and ANGPTL6 levels among individuals diagnosed with type 2 diabetes and obesity who underwent a 20-week intermittent Very Low-Calorie Diet (VLCD) regimen.
  • The analysis revealed no significant correlation between the changes in ANGPTL2 and ANGPTL6 levels and the remission of diabetes.

Risk of Dementia According to the Reproductive factors in Postmenopausal women with Diabetes

  • The researchers conducted a study to examine how reproductive factors affect the likelihood of developing dementia in women with diabetes.
  • A longer reproductive lifespan has been linked to a reduced risk of dementia in postmenopausal women with diabetes.

The Condition Of The Heart And Myocardial Changes In Patients With Type 2 Diabetes

  • The underlying mechanisms of myocardial changes in individuals with type 2 diabetes (T2D) is not completely understood, thereby constraining the development of effective prevention and treatment strategies for diabetic-associated cardiomyopathy (DAC). Enhancing our comprehension of myocardial alterations in type 2 diabetes holds the potential to enhance the prognosis and treatment efficacy for patients afflicted with this condition.
  • The analysis of the data reveals that elevated glucose levels, regardless of the presence of arterial hypertension, result in myocardial hypertrophy and remodeling.

The Efficacy Of Glp1 Receptor Agonists As Adjunct Therapy To Insulin In Patients With Type 1 Diabetes: A Meta-analysis

  • The objective of this study is to assess the impact of incorporating GLP-1 receptor agonists into insulin therapy for individuals with type 1 diabetes. The study will examine the effects on blood sugar regulation, body weight, insulin requirements, and cardiovascular safety. By conducting a comprehensive analysis of current literature, the aim is to evaluate the advantages and potential drawbacks of this combined treatment approach.
  • This meta-analysis, comprising 12 studies with 1567 participants, demonstrates the substantial advantages of GLP-1 RA therapy in the management of type 1 diabetes. However, it also underscores the importance of customizing treatments and conducting additional research to address the identified heterogeneity.

The Independent Association of Low LDL Cholesterol Levels with Diabetes Development Beyond Statin Influence

  • Recent studies have shown that individuals who use statins are at a higher risk of diabetes progression compared to those who do not use statins. The focus of many of these studies has been on the relationship between low LDL levels resulting from statin therapy and the progression of diabetes. Our goal is to investigate whether low LDL levels are independently associated with an increased risk of developing diabetes, irrespective of statin use.
  • The study results indicate that there is no clear link between LDL cholesterol levels below 70 mg/dl and the likelihood of developing diabetes mellitus or fasting serum glucose levels in a prospective community-based cohort of middle-aged adults. This association remains insignificant even when excluding individuals with pre-existing diabetes and those taking statin medications.

A Meta-Analysis Evaluating the Efficacy of Liraglutide in Reducing Cardiovascular Complications Among Patients With Type 2 Diabetes

  • The aim of this study was to assess the effectiveness of Liraglutide in reducing cardiovascular complications.
  • In comparison to a placebo, Liraglutide demonstrated a significant decrease in major adverse cardiovascular events (MACE), cardiovascular events, all-cause mortality, and severe hypoglycemia as an adverse event.

The ENDO 2024 conference offered a wide variety of sessions that delved into topics beyond diabetes, including thyroid function, reproductive health, and more. This comprehensive and enriching educational experience provided attendees with valuable insights and knowledge. To view the remaining posters from ENDO 24, we recommend clicking here and we look forward to next year!

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