The International Society on Thrombosis and Haemostasis held its annual conference (ISTH 2024) in Bangkok, Thailand from June 22-26th. It is the premier global organization dedicated to advancing the understanding, prevention, diagnosis, and treatment of conditions related to thrombosis and hemostasis.

During ISTH 2024, groundbreaking research on venous thromboembolism (VTE) was presented, showcasing the latest developments and breakthroughs in the field. This research provides valuable insights for healthcare professionals and researchers, offering new perspectives and potential solutions to improve patient outcomes.

Let’s delve into the highlights of the research presented at ISTH 2024, focusing on VTE, and explore the cutting-edge advancements that are shaping the landscape of thrombosis and hemostasis.

Venous thromboembolic disease in patients with inherited bleeding disorders

  • Key Takeaways
    • A deficiency in coagulation factors in inherited bleeding disorders may seem to provide protection against thrombosis in theory, but clinical experience tells a different story. There is limited information available on the simultaneous presence of these conditions. Researchers have recently shared their findings on adult patients who have been diagnosed with VTD and inherited bleeding disorders.
    • The study showed a potential coexistence of VTD and inherited bleeding disorders. Interestingly, DOACs demonstrated comparable effectiveness and safety to VKAs in patients with both thrombophilia and inherited bleeding disorders. These results underscore the importance of conducting thorough assessments when managing such complex medical conditions.
  • Link

The utility of D-dimer in excluding the diagnosis of proximal deep vein thrombosis in the anticoagulated population

  • Key Takeaways
    • The objective of this study was to assess the performance of D-dimer in excluding proximal deep vein thrombosis (pDVT) in patients on direct-acting oral anticoagulant (DOAC) who were admitted to the emergency department (ED) and received lower-limb compression ultrasound for suspected DVT.
    • Patients on chronic DOAC therapy, plasma D-dimer levels demonstrate a high sensitivity and negative predictive value. This study indicates a potential utility of plasma D-dimer levels in ruling out Pulmonary Embolism (PE) in patients on DOAC therapy who are clinically suspected of having PE.
  • Link

Rare Variant Aggregate Association Testing VTE Meta-Analysis: the INVENT Consortium

  • Key Takeaways
    • This study delved into the aggregation of rare variants identified through whole-genome sequencing (WGS) and dense imputation in order to pinpoint genes containing rare genetic variants that are linked to VTE.
    • The researchers discovered unique and uncommon genetic variations in genes that have recently been linked to VTE, as well as genes that were previously associated with the condition.
  • Link

Estimating in hospital and post-discharge venous and arterial thrombotic events in patients with COVID-19

  • Key Takeaways
    • The researchers evaluated the incidence of venous and arterial thromboembolic (VTE, ATE) events in adult patients with acute COVID-19 both during hospitalization and up to 60 days after discharge.
    • In this nationwide multicenter cohort study, a significant occurrence of VTE and ATE was observed among COVID-19 patients during their hospital stay, with the risk persisting for up to 60 days after discharge.
  • Link

Thrombotic events after vaccination against COVID 19: A case series

  • Key Takeaways
    • The objective of this study was to analyze the alterations in coagulation tests, diagnostic methods, and treatment outcomes for thrombosis induced by the Covid-19 vaccine.
    • Various Covid-19 vaccines have been associated with an increased risk of thrombosis. This risk appears to be higher in females. Early detection of thrombosis and the simultaneous administration of antiaggregants and anticoagulant medications can help prevent complications arising from vaccine-induced thrombosis.
  • Link

Association of hemostatic and inflammatory biomarkers with functional limitations three months after venous thromboembolism: Results from a prospective cohort study

  • Key Takeaways
    • The researchers examined the correlation between hemostatic and inflammatory biomarkers and functional limitations three months following a VTE diagnosis.
    • Hemostatic and inflammatory biomarkers were found to be independently correlated with functional limitations three months following a VTE, indicating a potential underlying pathophysiological mechanism.
  • Link

Biomarkers for prediction of thrombus resolution after acute deep vein thrombosis in the lower extremities

  • Key Takeaways
    • The researchers examined the correlation between hemostatic and inflammatory biomarkers and functional limitations three months following a VTE diagnosis.
    • In this pilot study, researchers discovered that measuring FVIII and PAI-1 levels at the onset of acute DVT could help predict the resolution of thrombosis at 3 months.
  • List

Safety and efficacy of low molecular weight heparin in patients with acute venous thromboembolism post-thrombolytic therapy as compared to unfractionated heparin: A systematic Review and Meta-analysis

  • Key Takeaways
    • This study assessed the existing evidence regarding the use of low molecular weight heparin (LMWH) compared to unfractionated heparin (UFH) in post-thrombolysis.
    • LMWH may offer a lower risk of VTE recurrence, bleeding complications, and 30-day mortality compared to UFH.
  • Link

Polygenic risk score predictor of pulmonary embolism among those with a deep vein thrombosis: the INVENT Consortium

  • Key Takeaways
    • Identifying the polygenic risk factors associated with pulmonary embolism (PE) in individuals with DVT could provide valuable insights into the risk of developing PE.
    • The researchers have identified a slight correlation between genome-wide genetic variation PRS and the risk of PE in individuals with DVT. Ancestry-stratified analyses are currently in progress.
  • Link


Thank you for joining us for this recap of the ISTH 2024. We recommend visiting this link to explore the entirety of these posters as well as the many others that were showcased during the exciting event!

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