Combined Phase 3, Double-blind, Randomized, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Filgotinib in the Induction and Maintenance of Remission in Subjects With Moderately to Severely Active Crohn's Disease

ClinicalTrials.gov processed this data on November 24, 2023. Link to the current ClinicalTrials.gov record.

Recruitment Status

COMPLETED - HAS RESULTS
 (See Contacts and Locations)
Verified November 2023 by Galapagos NV, Gilead Sciences

Sponsor

Galapagos NV

Information Provided by (Responsible Party)

Galapagos NV

Clinicaltrials.gov Identifier

NCT02914561
Other Study ID Numbers: GS-US-419-3895
First Submitted: September 22, 2016
First Posted: September 26, 2016
Results First Posted: December 18, 2023
Last Update Posted: December 18, 2023
Last Verified: November 2023
History of Changes

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Study Description

Not Provided
Condition or Disease Intervention/Treatment
  • Crohn's Disease
  • Drug: Filgotinib
  • Other: Placebo

Study Design

Study TypeInterventional
Actual Enrollment1372 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingDouble
Primary PurposeTreatment
Official TitleCombined Phase 3, Double-blind, Randomized, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Filgotinib in the Induction and Maintenance of Remission in Subjects With Moderately to Severely Active Crohn's Disease
Study Start DateOctober 31, 2016
Actual Primary Completion DateNovember 11, 2022
Actual Study Completion DateNovember 11, 2022

Groups and Cohorts

Group/ CohortIntervention/ Treatment
  • Cohort A: Filgotinib 200 (mg) (Induction Study)
    • Biologic naïve and biologic experienced participants received filgotinib 200 milligram (mg) with placebo-to-match (PTM) filgotinib 100 mg tablet orally once daily, for a period of 10 weeks.
  • Drug: Filgotinib
    • Filgotinib tablets administered orally once daily.
  • Other: Placebo
    • Cohort A: Filgotinib 100 mg (Induction Study)
      • Biologic naïve and biologic experienced participants received filgotinib 100 mg with PTM filgotinib 200 mg tablet orally once daily, for a period of 10 weeks.
    • Drug: Filgotinib
      • Filgotinib tablets administered orally once daily.
    • Other: Placebo
      • Cohort A: Placebo (Induction Study)
        • Biologic naïve and biologic experienced participants received PTM filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks.
      • Drug: Filgotinib
        • Filgotinib tablets administered orally once daily.
      • Other: Placebo
        • Cohort B: Filgotinib 200 mg (Induction Study)
          • Biologic experienced participants received filgotinib 200 mg with PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks.
        • Drug: Filgotinib
          • Filgotinib tablets administered orally once daily.
        • Other: Placebo
          • Cohort B: Filgotinib 100 mg (Induction Study)
            • Biologic experienced participants received filgotinib 100 mg with PTM filgotinib 200 mg tablet orally once daily, for a period of 10 weeks.
          • Drug: Filgotinib
            • Filgotinib tablets administered orally once daily.
          • Other: Placebo
            • Cohort B: Placebo (Induction Study)
              • Biologic experienced participants received PTM filgotinib 200 mg with PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks.
            • Drug: Filgotinib
              • Filgotinib tablets administered orally once daily.
            • Other: Placebo
              • Filgotinib 200 mg to Filgotinib 200 mg (Maintenance Study)
                • Participants who received filgotinib 200 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, up to Week 58.
              • Drug: Filgotinib
                • Filgotinib tablets administered orally once daily.
              • Filgotinib 200 mg to Placebo (Maintenance Study)
                • Participants who received filgotinib 200 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 100 mg and PTM filgotinib 200 mg tablet orally once daily, up to Week 58.
              • Drug: Filgotinib
                • Filgotinib tablets administered orally once daily.
              • Other: Placebo
                • Filgotinib 100 mg to Filgotinib 100 mg (Maintenance Study)
                  • Participants who received filgotinib 100 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received filgotinib 100 mg and PTM filgotinib 200 mg tablet orally once daily, up to Week 58.
                • Drug: Filgotinib
                  • Filgotinib tablets administered orally once daily.
                • Filgotinib 100 mg to Placebo (Maintenance Study)
                  • Participants who received filgotinib 100 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, up to Week 58.
                • Drug: Filgotinib
                  • Filgotinib tablets administered orally once daily.
                • Other: Placebo
                  • Placebo to Placebo (Maintenance Study)
                    • Participants who received placebo in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 100 mg and PTM filgotinib 200 mg tablet orally once daily, up to Week 58.
                  • Other: Placebo

                    Outcome Measures

                    Primary Outcome Measures

                    1. Induction Study: Percentage of Participants Who Achieved Clinical Remission by Crohn's Disease Activity Index (CDAI) at Week 10 [Week 10]
                      The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The subscores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.

                      Clinical remission was defined as a CDAI of < 150 points.
                    2. Induction Study: Percentage of Participants Who Achieved Endoscopic Response at Week 10 [Week 10]
                      The Simple Endoscopic Score for Crohn's Disease (SES-CD) assessed the degree of inflammation on the basis of 4 components: size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each of these components was scored on a scale of 0 to 3 (worst). In the SES-CD, each of these 4 components are assessed in the five segments: ileum, right colon, transverse colon, left colon, and rectum. The SES-CD was the sum of the individual scores of each of the components across the five segments. The range of SES-CD scores was 0 - 12 for each segment, and 0 - 60 for the overall SES-CD score, with larger scores indicating greater severity of disease. Endoscopic response was defined as ≥ 50% reduction from baseline in total SES-CD score.
                    3. Maintenance Study: Percentage of Participants Who Achieved Clinical Remission by CDAI at Week 58 [Week 58]
                      The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The sub scores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.

                      Clinical remission was defined as a CDAI of < 150 points.
                    4. Maintenance Study: Percentage of Participants Who Achieved Endoscopic Response at Week 58 [Week 58]
                      The SES-CD assessed the degree of inflammation on the basis of 4 components: size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each of these components was scored on a scale of 0 to 3 (worst). In the SES-CD, each of these 4 components are assessed in the five segments: ileum, right colon, transverse colon, left colon, and rectum. The SES-CD was the sum of the individual scores of each of the components across the five segments. The range of SES-CD scores was 0 - 12 for each segment, and 0 - 60 for the overall SES-CD score, with larger scores indicating greater severity of disease. Endoscopic response was defined as ≥ 50% reduction from baseline in total SES-CD score.

                    Secondary Outcome Measures

                    1. Induction Study: Percentage of Participants Who Achieved Clinical Remission by PRO2 at Week 10 [Week 10]
                      The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days. Clinical Remission was defined as the average daily stool score ≤3 points AND average daily abdominal pain score ≤1 point.
                    2. Induction Study: Percentage of Participants Who Achieved Clinical Response by CDAI at Week 10 [Week 10]
                      The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The subscores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.

                      Clinical response was defined as reduction in CDAI score from Induction baseline by at least 100 points or CDAI score < 150 points.
                    3. Maintenance Study: Percentage of Participants Who Achieved Clinical Remission by PRO2 at Week 58 [Week 58]
                      The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days. Clinical Remission was defined as the average daily stool score ≤3 points AND average daily abdominal pain score ≤1 point.
                    4. Maintenance Study: Percentage of Participants Who Achieved Clinical Response by CDAI at Week 58 [Week 58]
                      The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The sub scores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.

                      Clinical response was defined as reduction in CDAI score from Induction baseline by at least 100 points or CDAI score < 150 points.
                    5. Maintenance Study: Percentage of Participants Who Achieved Sustained Clinical Remission by CDAI at Both Weeks 10 and 58 [Weeks 10 and 58]
                      The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The sub scores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.

                      Sustained Clinical Remission by CDAI: CDAI <150 combined at both Week 10 and Week 58.
                    6. Maintenance Study: Percentage of Participants Who Achieved 6 Month Corticosteroid-Free Remission by CDAI at Week 58 [Week 58]
                      The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The subscores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.

                      6-Month Corticosteroid-Free Clinical remission by CDAI: CDAI <150 with no corticosteroid use for indication of Crohn's disease for at least 6 months prior to Week 58.
                    7. Maintenance Study: Percentage of Participants Who Achieved Sustained Clinical Remission by PRO2 at Both Weeks 10 and 58 [Weeks 10 and 58]
                      The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days.

                      Sustained Clinical Remission by PRO2: liquid or very soft stool ≤3 and abdominal pain ≤1 combined at both Week 10 and Week 58.
                    8. Maintenance Study: Percentage of Participants Who Achieved 6 Month Corticosteroid-Free Remission by PRO2 at Week 58 [Week 58]
                      The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days.

                      6-month Corticosteroid-Free Clinical Remission by PRO2: liquid or very soft stool ≤3 and abdominal pain ≤1 with no corticosteroid use for at least 6 months prior to Week 58.
                    9. Induction Study:Pharmacokinetic Plasma Concentrations of Filgotinib at Week 4 [Week 4: 0.5, 1, 2, and 3 hours (hrs) post dose]
                      Plasma concentrations of filgotinib [nanogram/milliliters (ng/mL)].
                    10. Induction Study: Pharmacokinetic Plasma Concentrations of Filgotinib at Week 10 [Week 10: Predose]
                      Plasma concentrations of filgotinib (ng/mL).
                    11. Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib at Week 26 [Week 26: At any timepoint]
                      Plasma concentrations of filgotinib (ng/mL).
                    12. Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib at Week 58 [Week 58: Pre-dose]
                      Plasma concentrations of filgotinib (ng/mL).
                    13. Induction Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 4 [Week 4: 0.5, 1, 2, and 3 hrs post dose]
                      Plasma concentrations of GS-829845 (ng/mL).
                    14. Induction Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 10 [Week 10: Predose]
                      Plasma concentrations of GS-829845 (ng/mL).
                    15. Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 26 [Week 26: At any timepoint]
                      Plasma concentrations of GS-829845 (ng/mL).
                    16. Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 58 [Week 58: Pre-dose]
                      Plasma concentrations of GS-829845 (ng/mL).

                    Eligibility Criteria

                    Ages Eligible for Study 18 Years to 75 Years (Adult, Older Adult)
                    Sexes Eligible for Study All
                    Accepts Healthy Volunteers No
                    Inclusion Criteria
                    • a:
                    • Documented diagnosis of CD with a minimum disease duration of 3 months with involvement of the ileum and/or colon at a minimum, as determined by histopathology and endoscopic assessment
                    • Moderately to severely active CD
                    • Cohort A (Biologic Naïve): Previously demonstrated an inadequate clinical response, loss of response to, or intolerance to at least 1 of the following agents (depending on current country treatment recommendations/guidelines): corticosteroids and immunomodulators
                    • Cohort A (Biologic Experienced): Previously demonstrated an inadequate clinical response, loss of response to, or intolerance to at least 1 of the following agents (depending on current country treatment recommendations/guidelines) or discontinuation of use of at least one of the following agents for reasons other than inadequate clinical response, loss of response or intolerance: tumor necrosis factor alpha (TNFa) antagonists, vedolizumab, and ustekinumab
                    • Cohort B (Biologic Experienced): Previously demonstrated an inadequate clinical response, loss of response to, or intolerance to at least 1 of the following agents (depending on current country treatment recommendations/guidelines): TNFa antagonists, vedolizumab, and ustekinumab
                    • Ke
                    Exclusion Criteria
                    • Current complications of CD such as symptomatic strictures, severe rectal/anal stenosis, fistulae other than perianal fistulae, short bowel syndrome, etc.
                    • Presence of ulcerative colitis, indeterminate colitis, ischemic colitis, fulminant colitis, or toxic mega-colon
                    • Active tuberculosis (TB) or history of latent TB that has not been treated
                    • Use of any prohibited concomitant medications as described in the study protocol
                    • NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.

                    Contacts and Locations

                    Sponsors and Collaborators Galapagos NV, Gilead Sciences
                    Gilead Sciences
                    Locations
                    • Digestive Health Specialists of the Southeast | Dothan, Alabama, United States, 36305
                    • Arizona Digestive Health - Sun City | Sun City, Arizona, United States, 85351
                    • Southern California Research Center, Inc. | Coronado, California, United States, 92118
                    • VVCRD Research | Garden Grove, California, United States, 92845
                    • UC San Diego Health System | La Jolla, California, United States, 92037
                    • Cedars Sinai Medical Center | Los Angeles, California, United States, 90048
                    • Inland Empire Clinical Trials, LLC | Rialto, California, United States, 92377
                    • Kaiser Permanente | San Francisco, California, United States, 94118
                    • Clearview Medical Research, LLC | Santa Clarita, California, United States, 91351
                    • University of Colorado Denver and Hospital | Aurora, Colorado, United States, 80045
                    • South Denver Gastroenterology, PC | Lone Tree, Colorado, United States, 80124
                    • Connecticut GI, PC-Research Division | Farmington, Connecticut, United States, 06032
                    • Medstar Georgetown University Hospital (Patient Exams) | Washington, District of Columbia, United States, 20007
                    • Advanced Research, LLC | Coral Springs, Florida, United States, 33067
                    • UF Clinical Research Center | Gainesville, Florida, United States, 32610
                    • Florida Research Institute | Lakewood Ranch, Florida, United States, 34211
                    • Florida Center for Gastroenterology | Largo, Florida, United States, 33777
                    • University of Miami Crohn's and Colitis Center | Miami, Florida, United States, 33136
                    • Advanced Pharma CR | Miami, Florida, United States, 33147
                    • Cordova Research Institute | Miami, Florida, United States, 33155
                    • Vista Health Research, LLC | Miami, Florida, United States, 33176
                    • Gastroenterology Group of Naples | Naples, Florida, United States, 34102
                    • Center for Interventional Endoscopy - AdventHealth Orlando | Orlando, Florida, United States, 32803
                    • Gulf Region Clinical Research Institute | Pensacola, Florida, United States, 32514
                    • Advanced Medical Research Center | Port Orange, Florida, United States, 32127
                    • Tampa General Hospital | Tampa, Florida, United States, 33606
                    • Shafran Gastroenterology Center | Winter Park, Florida, United States, 32789
                    • Florida Medical Clinic, P.A. | Zephyrhills, Florida, United States, 33540
                    • Gastroenterology Associates of Central Georgia, LLC | Macon, Georgia, United States, 31201
                    • Gastrointestinal Specialists of Georgia | Marietta, Georgia, United States, 30060
                    • Atlanta Gastroenterology Specialist, PC | Suwanee, Georgia, United States, 30024
                    • Illinois Gastroenterology Group - Arlington Heights | Arlington Heights, Illinois, United States, 60005
                    • Northwestern University, Feinberg School of Medicine | Chicago, Illinois, United States, 60611
                    • University of Chicago Medical Center | Chicago, Illinois, United States, 60637
                    • Illinois Gastroenterology Group - Gurnee | Gurnee, Illinois, United States, 60031
                    • Indiana University Health University Hospital | Indianapolis, Indiana, United States, 46202
                    • University of Iowa Hospitals and Clinics | Iowa City, Iowa, United States, 52242
                    • University of Kansas Medical Center | Kansas City, Kansas, United States, 66160
                    • University of Louisville, School of Medicine | Louisville, Kentucky, United States, 40202
                    • Delta Research Partners, LLC | Monroe, Louisiana, United States, 71201
                    • Louisiana Research Center, LLC | Shreveport, Louisiana, United States, 71105
                    • Investigative Clinical Research | Annapolis, Maryland, United States, 21401
                    • University of Maryland Medical Center | Baltimore, Maryland, United States, 21201
                    • MGG Group Co., Inc., Chevy Chase Clinical Research | Chevy Chase, Maryland, United States, 20815
                    • Gastro Center of Maryland | Columbia, Maryland, United States, 21045
                    • Meritus Center for Clinical Research | Hagerstown, Maryland, United States, 21742
                    • Massachusetts General Hospital - Crohn's and Colitis Center | Boston, Massachusetts, United States, 02114
                    • Clinical Research Institute of Michigan, LLC | Chesterfield, Michigan, United States, 48047
                    • Spectrum Health Butterworth Hospital | Grand Rapids, Michigan, United States, 49546
                    • Mayo Clinic | Rochester, Minnesota, United States, 55902
                    • University of Mississippi Medical Center | Jackson, Mississippi, United States, 39216
                    • Kansas City Research Institute | Kansas City, Missouri, United States, 64131
                    • Washington University School of Medicine | Saint Louis, Missouri, United States, 63110
                    • Las Vegas Medical Research | Las Vegas, Nevada, United States, 89113
                    • AGA Clinical Research Associates, LLC | Egg Harbor Township, New Jersey, United States, 08234
                    • NY Scientific | Brooklyn, New York, United States, 11235
                    • NYU Langone Long Island Clinical Research Associates | Great Neck, New York, United States, 11021
                    • New York University School of Medicine/NYU Gastroenterology Associates | New York, New York, United States, 10016
                    • Lenox Hill Hospital | New York, New York, United States, 10028
                    • Premier Medical Group of the Hudson Valley | Poughkeepsie, New York, United States, 12601
                    • Charlotte Gastroenterology & Hepatology, PLLC | Charlotte, North Carolina, United States, 28207
                    • Carolina's GI Research, LLC | Raleigh, North Carolina, United States, 27607
                    • Fargo Gastroenterology and Hepatology Clinic | Fargo, North Dakota, United States, 58103
                    • Consultants for Clinical Research | Cincinnati, Ohio, United States, 45219
                    • UC Health Physicians Clifton | Cincinnati, Ohio, United States, 45219
                    • Great Lakes Gastroenterology Research, LLC, | Mentor, Ohio, United States, 44060
                    • Paramount Medical Research & Consulting, LLC | Middleburg Heights, Ohio, United States, 44130
                    • Options Health Research LLC | Tulsa, Oklahoma, United States, 74104
                    • Great Lakes Medical Research, LLC | Harrisburg, Pennsylvania, United States, 17110
                    • Gastroenterology Associates of Orangeburg | Orangeburg, South Carolina, United States, 29118
                    • WR-ClinSearch, LLC | Chattanooga, Tennessee, United States, 37421
                    • Gastro One | Germantown, Tennessee, United States, 38138
                    • Quality Medical Research | Nashville, Tennessee, United States, 37211
                    • Vanderbilt University Medical Center - IBD Clinic | Nashville, Tennessee, United States, 37212
                    • Texas Clinical Research Institute | Arlington, Texas, United States, 76012
                    • Pinnacle Clinical Research | Austin, Texas, United States, 78757
                    • Inquest Clinical Research | Baytown, Texas, United States, 77521
                    • San Antonio Military Medical Center | Fort Sam Houston, Texas, United States, 78219
                    • DHAT Research Institute | Garland, Texas, United States, 75044
                    • Kelsey-Seybold Clinic | Houston, Texas, United States, 77025
                    • Baylor College of Medicine- Baylor Medical Center | Houston, Texas, United States, 77030
                    • The Methodist Hospital | Houston, Texas, United States, 77030
                    • The University of Texas Health Science Center at Houston | Houston, Texas, United States, 77030
                    • Centex Studies, Inc. | Houston, Texas, United States, 77058
                    • Gulf Coast Research Group | Houston, Texas, United States, 77098
                    • Clinical Associates in Research Therapeutics of America, LLC | San Antonio, Texas, United States, 78212
                    • Gastroenterology Research of San Antonio | San Antonio, Texas, United States, 78229
                    • Pinnacle Clinical Research | San Antonio, Texas, United States, 78229
                    • TDDC San Marcos | San Marcos, Texas, United States, 78666
                    • Texas Digestive Disease Consultants (IP Shipment) | Southlake, Texas, United States, 76092
                    • Spring Gastroenterology | The Woodlands, Texas, United States, 77380
                    • Tyler Research Institute, LLC | Tyler, Texas, United States, 75701
                    • HP Clinical Research | Bountiful, Utah, United States, 84010
                    • University of Virginia Health System | Charlottesville, Virginia, United States, 22908
                    • Charlottesville Medical Research Center, LLC | Charlottesville, Virginia, United States, 22911
                    • Gastroenterology Associates of Tidewater | Chesapeake, Virginia, United States, 23320
                    • Emeritas Research Group LLC | Leesburg, Virginia, United States, 20176
                    • McGuire DVAMC, GI (111N) | Richmond, Virginia, United States, 23249
                    • Virginia Commonwealth University | Richmond, Virginia, United States, 23298
                    • University of Wisconsin Hospital & Clinics | Madison, Wisconsin, United States, 53792
                    • Wisconsin Center for Advanced Research, a division of GI Associates, LLC | Milwaukee, Wisconsin, United States, 53215
                    • Fundacion Estudios Clinicos CiRec | Rosario, Argentina, S2000DEF
                    • Royal Prince Alfred Hospital | Camperdown, New South Wales, Australia, 2050
                    • Monash Medical Centre | Clayton, New South Wales, Australia, 3168
                    • St. Vincent's Hospital Sydney | Darlinghurst, New South Wales, Australia, 2010
                    • Nepean Hospital | Kingswood, New South Wales, Australia, 2747
                    • Wollongong Hospital | Wollongong, New South Wales, Australia, 2500
                    • Coastal Digestive Health | Mountain Creek, Queensland, Australia, 4557
                    • Coral Sea Clinical Research Institute (Mackay) | North Mackay, Queensland, Australia, 4740
                    • Mater Misericordiae Ltd | South Brisbane, Queensland, Australia, 4101
                    • Princess Alexandra Hospital | Woolloongabba, Queensland, Australia, 4102
                    • Flinders Medical Centre | Bedford Park, South Australia, Australia, 5042
                    • The Queen Elizabeth Hospital | Woodville South, South Australia, Australia, 5011
                    • Emeritus Research | Camberwell, Victoria, Australia, 3124
                    • Footscray Hospital | Footscray, Victoria, Australia, 3011
                    • Austin Health | Heidelberg, Victoria, Australia, 3084
                    • Cabrini Hospital | Malvern, Victoria, Australia, 3144
                    • Alfred Hospital | Melbourne, Victoria, Australia, 3004
                    • Royal Melbourne Hospital | Parkville, Victoria, Australia, 3050
                    • Universitatsklinik Innsbruck | Innsbruck, Austria, 6020
                    • AKH-Medizinische Universitat Wien | Wien, Austria, 1090
                    • GZA Ziekenhuizen campus Sint-Vincentius | Antwerpen, Belgium, 2018
                    • Imelda General Hospital | Bonheiden, Belgium, 2820
                    • CUB Hopital Erasme | Brussel, Belgium, 1070
                    • Universitair Ziekenhuis Gent | Gent, Belgium, 9000
                    • Universitair Ziekenhuis Leuven | Leuven, Belgium, 3000
                    • CHR Citadelle | Liege, Belgium, 4000
                    • Centre Hospitalier Chretien (CHC) - Clinique Saint-Joseph | Liège, Belgium, 4000
                    • AZ Delta Campus Wilgenstraat | Roeselare, Belgium, 8800
                    • Medical Center - Complete Medical Solutions OOD | Samokov, Bulgaria, 2000
                    • Medical Center - "Tsaritsa Yoanna" EOOD | Sliven, Bulgaria, 8800
                    • "MDHAT Dr. St.Cherkezov" AD | Veliko Tarnovo, Bulgaria, 5000
                    • MHAT "Sveta Petka" AD | Vidin, Bulgaria, 3700
                    • Barrie GI Associates | Barrie, Canada, L4M 7G1
                    • University of Calgary, Heritage Medical Research Clinic | Calgary, Canada, T2N 4Z6
                    • Hamilton Health Sciences Corporation, McMaster University Medical Centre | Hamilton, Canada, L8S 4K1
                    • London Health Sciences Centre - University Hospital | London, Canada, N6A 5A5
                    • TIDHI Innovation Inc. | North York, Canada, M6A 3B4
                    • ABP Research Services | Oakville, Canada, L6L 5L7
                    • Royal University Hospital | Saskatoon, Canada, S7N 0W8
                    • The Gordon and Leslie Diamond Health Care Centre | Vancouver, Canada, V5Z 1M9
                    • Toronto Digestive Disease Associates Inc. | Vaughan, Canada, L4L 4Y7
                    • Percuro Clinical Research Ltd. | Victoria, Canada, V8V 3M9
                    • University Hospital Center Osijek | Osijek, Croatia, 31 000
                    • Clinical Hospital Dubrava | Zagreb, Croatia, 10000
                    • University Hospital Center Zagreb | Zagreb, Croatia, 10000
                    • Hepato-Gastroenterologie HK, s.r.o. | Hradec Kralove, Czechia, 500 12
                    • Oblastni nemocnice Mlada Boleslav, a.s., nemocnice Stredoceskeho kraje, Gastroenterologicke oddeleni | Mlada Boleslav, Czechia, 293 01
                    • G.E.P. Clinic, s r.o. | Praha 3, Czechia, 130 00
                    • Thomayerova nemocnice, Interni klinika 3. LF UK a TN (Interni Oddeleni) | Praha 4, Czechia, 140 00
                    • ISCARE a.s. (Klinicke centrum ISCARE), Klinicke a vyzkumne centrum pro strevni zanety | Praha 9, Czechia, 190 00
                    • CHU Amiens Picardie | Amiens Cedex 1, France, 80054
                    • CHU de Caen | Caen Cedex 9, France, 14033
                    • CHU de Clermont-Ferrand - Hopital d'Estaing | Clermont-Ferrand, France, 63003
                    • APHP - Hopital Beaujon - Clichy - Universite Paris VII | Clichy, France, 92110
                    • Centre Hospitalier Intercommunal de Creteil | Créteil, France, 94010
                    • CHU de Dijon Bourgogne - Hopital Francois Mitterand | Dijon, France, 21079
                    • CHU Grenoble Alpes | La Tronche, France, 38700
                    • Hopital Universitaire de Bicetre | Le Kremlin Bicetre, France, 94270
                    • Centre Hospitalier Regional Universitaire de Lille | Lille, France, 59000
                    • Hopital Nord | Marseille, France, 13015
                    • Hopital Saint Joseph | Marseille, France, 13285
                    • CHU de Montpellier-Hopital Saint Eloi | Montpellier, France, 34295
                    • Centre d'Investigation Clinique - CHU Hotel-Dieu | Nantes, France, 44093
                    • Hopital de l'Archet 2 | Nice, France, 06202
                    • CHU de Bordeaux - Hopital Haut Leveque | Pessac, France, 33600
                    • Centre Hospitalier Universitaire de Lyon Sud | Pierre-Benite, France, 69495
                    • CH Annecy Genevois - Site d'Annecy | Pringy Cedex, France, 74374
                    • Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou | Rennes Cedex 9, France, 35033
                    • CHU de Saint-Etienne - Hopital Nord | Saint Priest en Jarez, France, 42055
                    • Nouvel Hopital Civil | Strasbourg, France, 67091
                    • Hopitaux Universitaires de Strasbourg - Hopital de Hautepierre | Strasbourg, France, 67098
                    • CHU de Toulouse - Hopital Rangueil | Toulouse Cedex 9, France, 31059
                    • CHU de Toulouse - Hopital Rangueil | Toulouse, France, 31059
                    • CHU de Nancy - Hopital Brabois Adultes | Vandoeuvre-les-Nancy Cedex, France, 54511
                    • Unimed Ajara LLC - Batumi Referral Hospital | Batumi, Georgia, 6010
                    • Medi Club Georgia LLC | Tbilisi, Georgia, 0160
                    • Ltd. Unimed Kakheti - Telavi Referral Hospital | Telavi, Georgia, 2200
                    • Charite Universitaetsmedizin Berlin | Berlin, Germany, 10117
                    • Gastro-Studien | Berlin, Germany, 10825
                    • Charite - Universitatsmedizin Berlin | Berlin, Germany, 13353
                    • DRK Kliniken Berlin - Westend - Klinik fuer Innere Medizin | Berlin, Germany, 14050
                    • Stadtisches Klinikum Braunschweig gGmbH | Braunschweig, Germany, 38126
                    • Agaplesion Markus Krankenhaus | Frankfurt am Main, Germany, 60431
                    • CED Studien UG, Interdisciplinary Crohn Colitis Center (iCCC) Rhein-Main | Frankfurt am Main, Germany, 60594
                    • Universitatsklinikum Freiburg | Freiburg, Germany, 79106
                    • Asklepios Westklinikum Hamburg | Hamburg, Germany, 22559
                    • Medizinische Hochschule Hannover | Hannover, Germany, 30625
                    • Universitatsklinikum Heidelberg | Heidelberg, Germany, 69120
                    • Praxis fur Gastroenterologie | Heidelberg, Germany, 69121
                    • Gastroenterologische Gemeinschaftspraxis Herne | Herne, Germany, 44623
                    • Universitatsklinikum Jena | Jena, Germany, 07747
                    • Universitatsklinikum Schleswig-Holstein | Kiel, Germany, 24105
                    • Universitatsklinik Koln | Koln, Germany, 50937
                    • EUGASTRO GmbH | Leipzig, Germany, 04103
                    • Universitatsklinikum Leipzig | Leipzig, Germany, 04103
                    • Klinikum Luneburg | Lüneburg, Germany, 21339
                    • Gastroenterologische Gemeinschaftspraxis Minden | Minden, Germany, 32423
                    • Klinikum der Universitat Munchen - Grosshadern | Muenchen, Germany, 81377
                    • Universitaetsmedizin Rostock, Zentrum fuer Innere Medizin | Rostock, Germany, 18057
                    • Universitaetsklinikum Tuebingen | Tuebingen, Germany, 72074
                    • Universitatsklinikum Ulm, Zentrum Fur Innere Medizin | Ulm, Germany, 89081
                    • General Hospital of Athens "Hippokratio", 2nd Internal Medicine Clinic of Athens University, Hepato-gastroenterology Unit | Athens, Greece, 11527
                    • University General Hospital "Attikon", 2nd Propaedeutic Internal Medicine Dept. and Research Unit, Hepatogastroenterology Unit | Athens, Greece, 12462
                    • University General Hospital of Ioannina, Gastroenterology Department, Internal Medicine Division | Ioannina, Greece, 45332
                    • University General Hospital of Patras "Panagia I Voithia", Gastroenterology Department, Internal Medicine Division | Patras, Greece, 26500
                    • General Hospital of Thessaloniki "Hippokratio", 4th Internal Medicine Department of Aristotle University of Thessaloniki | Thessaloniki, Greece, 54642
                    • Princess Margaret Hospital | Hong Kong, Hong Kong,
                    • Queen Mary Hospital | Hong Kong, Hong Kong,
                    • Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital | Shatin, Hong Kong,
                    • Tuen Mun Hospital | Tuen Mun, Hong Kong,
                    • Bekes Megyei Kosponti Korhaz, Dr. Rethy Pal Tagkorhaz, IV. Belgyogyaszat - 2. Gasztroenterologia | Bekescsaba, Hungary, 5600
                    • Szent Margit Korhaz, Gasztroenterológiai Osztály | Budapest, Hungary, 1032
                    • Clinexpert Egeszsegugyi Szolgaltato es Kereskedelmi Kft. | Budapest, Hungary, 1033
                    • Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, Kozponti Felnott Szakrendelo | Budapest, Hungary, 1097
                    • Szent Janos Korhaz es Eszak-budai Egitett Korhazak, I. Belgyogyaszati - Gasztroenterologiai Osztaly | Budapest, Hungary, 1125
                    • Debreceni Egyetem Klinikai Kozpont, II. sz. Belgyogyaszati Klinika, Gasztroenterologia | Debrecen, Hungary, 4032
                    • Bugat Pal Korhaz, Belgyogyaszat | Gyöngyös, Hungary, 3200
                    • Karolina Korhaz es Rendelointezet, Altalanos Belgyogyaszat-Gasztroenterologia | Mosonmagyarovar, Hungary, 9200
                    • Landspitali University Hospital | Reykjavik, Iceland, 101
                    • S.P. Medical College & AG of Hospitals | Bīkaner, Rajasthan, India, 334003
                    • Kaizen Hospital | Ahmedabad, India, 380052
                    • Gastroplus Digestive Disease Centre Pvt Ltd | Ahmedabad, India, 380054
                    • Sal Hospital and Medical Institute | Ahmedabad, India, 380054
                    • Victoria Hospital, Bangalore Medical College and Research Institute | Bangalore, India, 560002
                    • M S Ramaiah Medical College and Hospital | Bangalore, India, 560054
                    • KLES Dr. Prabhakar Kore Hospital & MRC | Belgaum, India, 590010
                    • BGS Global Hospital | Bengaluru, India, 560060
                    • Apollo Speciality Hospital | Chennai, India, 600035
                    • VGM Hospital Institute of Gastroenterology | Coimbatore, India, 641005
                    • Maharaja Agrasen Hospital | Delhi, India, 110026
                    • Lourdes Hospital | Ernakulam, India, 682012
                    • PVS Memorial Hospital Private Limited | Ernakulam, India, 682017
                    • Fortis Medical Research Institute | Gurgaon, India, 122002
                    • Institute of Digestive & Liver Diseases | Guwahati, India, 781006
                    • Gleneagles Global Hospitals | Hyderabad, India, 500004
                    • Citizens Specialty Hospital | Hyderabad, India, 500019
                    • Aware Gleneagles Global Hospitals | Hyderabad, India, 500035
                    • Centre for Liver Research & Diagnostics | Hyderabad, India, 500058
                    • Asian Institute of Gastroenterology Pvt Ltd | Hyderabad, India, 500082
                    • S.R.Kalla Memorial Gastro.&General Hospital | Jaipur, India, 302001
                    • S.M.S Medical College & Hospitals | Jaipur, India, 302004
                    • GSVM Medical College | Kanpur, India, 208002
                    • Lakeshore Hospital and Research Centre Ltd. | Kochi, India, 682040
                    • Amrita Institute of Medical Sciences and Research Centre | Kochi, India, 682041
                    • School of Digestive & Liver Diseases | Kolkata, India, 700020
                    • Apollo Gleneagles Hospitals | Kolkata, India, 700054
                    • King George's Medical University | Lucknow, India, 226003
                    • Dayanand Medical College & Hospital | Ludhiana, India, 141001
                    • Kasturba Medical College (KMC) Hospital | Mangaluru, India, 575001
                    • Seth G.S Medical College & KEM Hospital | Mumbai, India, 400012
                    • Lokmanya Tilak Municipal General Hospital | Mumbai, India, 400022
                    • Midas Multispeciality Hospital Pvt. Ltd | Nagpur, India, 440010
                    • Suretech Hospital & Research Centre Ltd | Nagpur, India, 440012
                    • Max Smart Super Speciality Hospital | New Delhi, India, 110017
                    • All India Institute of Medical Sciences | New Delhi, India, 110029
                    • Dr. B.L. Kapur Memorial Hospital | New Delhi, India, 11005
                    • Fortis Flt. Lt. Rajan Dhall Hospital | New Delhi, India, 110070
                    • S.L Raheja Hospital | Parel, India, 400012
                    • Department of Surgery, B.J. Government Medical College & Sassoon General Hospital | Pune, India, 411001
                    • Grant Medical Foundation Ruby Hall Clinic | Pune, India, 411001
                    • Universal Hospital | Pune, India, 411011
                    • Shree Giriraj Multispeciality Hospital | Rajkot, India, 360002
                    • Gandhi Hospital | Secunderabad, India, 500003
                    • Institute of Gastroenterology & Liver Disease. Sunshine Hospitals | Secunderabad, India, 500003
                    • Surat Institute of Digestive Sciences | Surat, India, 395002
                    • BAPS Pramukh Swami Hospital | Surat, India, 395009
                    • Kasturba Hospital Medical College | Udupi, India, 576104
                    • Sterling Hospital | Vadodara, India, 390007
                    • Samvedna Hospital | Varanasi, India, 221005
                    • St. Vincent's University Hospital | Dublin, Ireland, 4
                    • Beaumont Hospital | Dublin, Ireland, 9
                    • Wellcome Trust HRB Clinical Research Facility | Dublin, Ireland, DUBLIN 8
                    • University Hospital Galway | Galway, Ireland, H91 YR71
                    • Emek Medical Center | Afula, Israel, 18101
                    • Soroka Medical Center | Be'er Sheva, Israel, 8410101
                    • Bnai Zion Medical Center | Haifa, Israel, 31048
                    • Rambam Health Care Campus | Haifa, Israel, 3109601
                    • The Edith Wolfson Medical Center | Holon, Israel, 5822012
                    • Shaare Zedek Medical Center | Jerusalem, Israel, 9103102
                    • Hadassah Medical Center | Jerusalem, Israel, 91120
                    • Meir Medical Center | Kefar Sava, Israel, 4428164
                    • Rabin Medical Center | Petah Tikva, Israel, 4941492
                    • The Chaim Sheba Medical Center | Ramat Gan, Israel, 5265601
                    • Tel Aviv Sourasky Medical Center | Tel Aviv-Yafo, Israel, 64239
                    • UOC Gastroenterologia II | Castellana Grotte, Italy, 70013
                    • U.O. Fisiopatologia Digestiva | Catanzaro, Italy, 88100
                    • UOC Medicina Interna | Cento, Italy, 44042
                    • Ospedale Clinicizzato SS. Annunziata - Dipartimento di Medicina | Chieti, Italy, 66100
                    • Gastroenterologia clinica - Azienda Ospedaliero-Universitaria Careggi | Firenze, Italy, 50134
                    • Endoscopia Digestiva Centralizzata | Milano, Italy, 20121
                    • UO Gastroenterologia | Modena, Italy, 40124
                    • UOC Gastroenterologia | Padova, Italy, 35128
                    • Azienda Ospedaliero-Universitaria Pisana - Presidio Ospedaliero Cisanello | Pisa, Italy, 56124
                    • UOC di Gastroenterologia ed Endoscopia Digestiva | Roma, Italy, 00133
                    • Istituto Clinico Humanitas | Rozzano, Italy, 20089
                    • A.O. Ordine Mauriziano di Torino | Torino, Italy, 10122
                    • Ohmori Toshihide gastro-intestinal Clinic | Ageo-shi, Japan, 362-0075
                    • Tokyo Medical and Dental University Hospital | Bunkyo-ku, Japan, 113-8519
                    • Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital | Chuo-ku, Japan, 060-0033
                    • Japanese Red Cross Fukuoka Hospital | Fukuoka-shi, Japan, 815-8555
                    • Tokai University Hachioji Hospital | Hachioji, Japan, 192-0032
                    • Medical corporation Ryowakai, Hamamatsu South Hospital | Hamamatsu-shi, Japan, 430-0846
                    • Hiroshima Prefectural Hospital | Hiroshima-shi, Japan, 734-8530
                    • Hiroshima University Hospital | Hiroshima, Japan, 734-8551
                    • Fukuoka University Hospital | Jonan-ku, Japan, 814-0180
                    • Nanpuh Hospital | Kagoshima-shi, Japan, 892 -8512
                    • Ofuna Chuo Hospital | Kamakura, Japan, 247-0056
                    • Tsujinaka Hospital | Kashiwa-city, Japan, 277-0871
                    • Saitama Medical Center, Saitama Medical University | Kawagoe, Japan, 350-8550
                    • Kitakyushu City Hospital Organization Kitakyushu Municipal Medical Center | Kitakyushu-shi, Japan, 802-0077
                    • Yamanashi Prefectural Central Hospital | Kofu-shi, Japan, 400-8506
                    • Kurume University Hospital | Kurume-shi, Japan, 830-0011
                    • Hidaka Coloproctology Clinic | Kurume-shi, Japan, 839-0809
                    • University Hospital, Kyoto Prefectural University of Medicine | Kyoto-shi, Japan, 602-8566
                    • The Jikei University Hospital | Minato-ku, Japan, 105-8471
                    • Kitasato University Kitasato Institute Hospital | Minato-ku, Japan, 108-8642
                    • Kyorin University Hospital | Mitaka-shi, Japan, 181-8611
                    • Iwate Medical University Hospital | Morioka-shi, Japan, 020-8505
                    • Aichi Medical University Hospital | Nagakute-shi, Japan, 480-1195
                    • Nagasaki University Hospital | Nagasaki-shi, Japan, 8528501
                    • Nagoya City University Hospital | Nagoya, Japan, 467-8602
                    • Saiseikai Niigata Daini Hospital | Nishi-ku, Japan, 950-1104
                    • Hyogo College of Medicine College Hospital | Nishinomiya, Japan, 663-8501
                    • Ishida IBD Clinic | Oita-shi, Japan, 870-0823
                    • Okayama University Hospital | Okayama-city, Japan, 700-8558
                    • Kinshukai Infusion Clinic | Osaka-City, Japan, 530-0011
                    • Osaka City University Hospital | Osaka, Japan, 545-8586
                    • Wakakusa-Daiichi Hospital | Osaka, Japan, 579-8056
                    • Shiga University of Medical Science Hospital | Otsu, Japan, 520-2192
                    • Saga-Ken Medical Centre Koseikan | Saga-shi, Japan, 840-8571
                    • Kitasato University Hospital, THE KITASATO INSTITUTE | Sagamihara, Japan, 252-0375
                    • Saga University Hospital | Saga, Japan, 849-8501
                    • Tokito Clinic | Saitama, Japan, 336-0963
                    • Toho University Sakura Medical Center | Sakura, Japan, 285-8741
                    • Sapporo Higashi Tokushukai Hospital | Sapporo-shi, Japan, 065-0033
                    • Sapporo Tokushukai Hospital | Sapporo, Japan, 004-0041
                    • National Hospital Organization Sendai Medical Center | Sendai, Japan, 983-8520
                    • Tokyo Yamate Medical Center | Shinjuku-ku, Japan, 169-0073
                    • Osaka University Hospital | Suita, Japan, 565-0871
                    • Kagawa Prefectural Central Hospital | Takamatsu-shi, Japan, 760-8557
                    • National Hospital Organization Takasaki General Medical Center | Takasaki-shi, Japan, 3700829
                    • Osaka Medical College Hospital | Takatsuki, Japan, 569-8686
                    • Ieda Hospital | Toyota-shi, Japan, 470-1219
                    • Wakayama Medical University Hospital | Wakayama-shi, Japan, 641-8509
                    • Yokohama Health Medicine Association Kannai Suzuki Clinic | Yokohama-shi, Japan, 231-0012
                    • Pusan National University Hospital | Busan, Korea, Republic of, 49241
                    • Yeungnam University Hospital | Daegu, Korea, Republic of, 42415
                    • Kyung Hee University Hospital | Guri-Si, Korea, Republic of, 471-701
                    • Hanyang University Guri Hospital | Gyeonggi-do, Korea, Republic of, 11923
                    • CHA Bundang Medical Center, CHA University | Seongnam-si, Korea, Republic of, 13496
                    • Seoul National University Hospital | Seoul, Korea, Republic of, 03080
                    • Kangbuk Samsung Hospital | Seoul, Korea, Republic of, 03181
                    • Yonsei University Health System, Severance Hospital | Seoul, Korea, Republic of, 03722
                    • Asan Medical Center | Seoul, Korea, Republic of, 05505
                    • Division of Gastroenterology, Department of Medicine, Samsung Medical Center | Seoul, Korea, Republic of, 06351
                    • The Catholic University of Korea, St. Vincent's Hospital | Suwon-si, Korea, Republic of, 16247
                    • Yonsei University Wonju Severance Christian Hospital | Wonju, Korea, Republic of, 220-701
                    • Universiti Kebangsaan Malaysia Medical Center | Cheras, Malaysia, 56000
                    • Hospital Pulau Pinang | George Town, Malaysia, 10990
                    • Hospital Queen Elizabeth | Kota Kinabalu, Malaysia, 88586
                    • University Malaya Medical Centre | Kuala Lumpur, Malaysia, 59100
                    • Hospital Tengku Ampuan Afzan | Kuantan, Malaysia, 25100
                    • NZW Alkmaar (Noordwest Ziekenhuisgroep) | Alkmaar, Netherlands, 1815 JD
                    • VU University Medical Centre | Amsterdam, Netherlands, 1081 HV
                    • Academic Medical Center (AMC) | Amsterdam, Netherlands, 1100
                    • Gelre Hospital | Apeldoorn, Netherlands, 7334
                    • University Medical Center Groningen (UMCG) | Groningen, Netherlands, 9700 RB
                    • Maastricht University Medical Centre | Maastricht, Netherlands, 6229 HX
                    • Erasmus University Medical Center | Rotterdam, Netherlands, 3015 CE
                    • Elisabeth-TweeSteden Hospital | Tilburg, Netherlands, 5022
                    • University Medical Center Utrecht | Utrecht, Netherlands, 3584 CX
                    • Christchurch Hospital | Christchurch, New Zealand, 8011
                    • Southern District Health Board - Dunedin Hospital | Dunedin, New Zealand, 9016
                    • Auckland City Hospital | Grafton, New Zealand, 1023
                    • Waikato Hospital | Hamilton, New Zealand, 3240
                    • Wellington Hospital | Newtown, New Zealand, 6021
                    • Bay of Plenty District Health Board - Tauranga Hospital | Tauranga, New Zealand, 3112
                    • Hutt Valley District Health Board - Hutt Valley Hospital | Wellington, New Zealand, 5010
                    • Vestre Viken Hospital Trust, Baerum Hospital | Drammen, Norway, 3004
                    • Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Gastroenterologii i Chorob Wewnetrznych | Bialystok, Poland, 15-276
                    • VITAMED Galaj i Cichomski spolka jawna | Bydgoszcz, Poland, 85-079
                    • Szpital Uniwersytecki nr 2 im. Dr. Jana Biziela w Bydgoszczy, Centrum Endoskopii Zabiegowej, Poradnia Chorob Jelitowych | Bydgoszcz, Poland, 85-168
                    • Gabinet Lekarski Janusz Rudzinski | Bydgoszcz, Poland, 85-681
                    • NZOZ INTER-MED, Centrum Endoskopowe | Czestochowa, Poland, 42-217
                    • Niepubliczny Zaklad Opieki Zdrowotnej ALL-MEDICUS | Katowice, Poland, 40-659
                    • Gabinet Endoskopii Przewodu Pokarmowego | Krakow, Poland, 31-009
                    • Centrum Medyczno-Diagnostyczne Prima-Med | Kraków, Poland, 30-015
                    • Krakowskie Centrum Medyczne Sp. z o.o. | Kraków, Poland, 31-501
                    • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Uniwerstyeckiego Szpitala Klinicznego nr 1 im. Norbert Barlickiego | Lodz, Poland, 90-153
                    • Trialmed Crs | Piotrków Trybunalski, Poland, 97-300
                    • Clinical Research Center Spolka z ograniczna odpowiedzialnoscia Medic-R Sp. k. | Poznan, Poland, 60-848
                    • Gabinet Lekarski Dr. Hab. N. Med. Bartosz Korczowski | Rzeszów, Poland, 35-301
                    • Endoskopia Sp. Z o.o. | Sopot, Poland, 81-756
                    • Twoja Przychodnia-Szczecinskie Centrum Medyczne | Szczecin, Poland, 71-434
                    • GASTROMED Kopon, Zmudzkinski i Wspolnicy Sp. j. Specjalistyczne Centrum Gastrologii i Endoskopii | Torun, Poland, 87-100
                    • H-T.Centrum Medyczne Spolka z Ograniczona Odpowiedzialnoscia Sp.K. | Tychy, Poland, 43-100
                    • Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie | Warsaw, Poland, 02-781
                    • Centrum Zdrowia MDM | Warszawa, Poland, 00-635
                    • WIP Warsaw IBD Point Profesor Kierkus | Warszawa, Poland, 00-728
                    • Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administacji w Warszawie | Warszawa, Poland, 02-507
                    • Medical Concierge Centrum Medyczne | Warszawa, Poland, 02-798
                    • Niepubliczny Zaklad Opieki Zrodotnej VIVAMED Jadwige Miecz | Warszawa, Poland, 03-580
                    • Bodyclinic | Warszawa, Poland, 03-712
                    • Centrum Medyczne Oporow | Wroclaw, Poland, 52-416
                    • Centrum Medyczne | Wroclaw, Poland, 54-204
                    • Hospital de Braga | Braga, Portugal, 4710-243
                    • Centro Hospitalar e Universitario de Coimbra, E.P.E. | Coimbra, Portugal, 3000-075
                    • Centro Hospitalar Cova de Beira, EPE | Covilhã, Portugal, 6200-251
                    • Centro Hospitalar do Algarve EPE | Faro, Portugal, 8000-386
                    • Hospital da Senhora da Oliveira Guimaraes, E.P.E. | Guimaraes, Portugal, 4835-044
                    • Hospital Beatriz Angelo | Loures, Portugal, 2674-514
                    • Centro Hospitalar de Sao Joao, EPE | Porto, Portugal, 4200-319
                    • Unidade Local de Saude do Alto Minho, EPE | Viana do Castelo, Portugal, 4904-858
                    • S.C. Centrul Medical Sana S.R.L., Gastroenterologie | Bucharest, Romania, 011025
                    • Spitalul Universitar de Urgenta Bucuresti - Sectia Medicina Interna II | Bucharest, Romania, 050098
                    • SC MedLife SA, Gastroenterologie | Bucuresti, Romania, 010719
                    • Spitalul Universitar de Urgenta Militar Central Dr. Carol Davila - Sectia Clinica de Gastroenterologie | Bucuresti, Romania, 010825
                    • Delta Health Care/ Ponderas Academic Hospital | Bucuresti, Romania, 014142
                    • Spitalul Clinic Colentina, Gastroenterologie | Bucuresti, Romania, 020125
                    • MedLife, Gastroenterologie | Bucuresti, Romania, 031784
                    • Gastromedica SRL, Gastroenterologie | Iasi, Romania, 700506
                    • Cabinet Particular Policlinic Algomed SRL | Timisoara, Romania, 300002
                    • Centrul Medical Tuculanu, Gastroenterologie | Timisoara, Romania, 300168
                    • S.C. Policlinica Dr. Citu S.R.L.- Gastroenterologie | Timisoara, Romania, 300594
                    • State Budgetary Healthcare Institute "Chelyabinsk Regional Clinical Hospital" | Chelyabinsk, Russian Federation, 454076
                    • State Budgetary Institution of Health Irkustsk Order "Badge of Honor" Regional Clinical Hospital | Irkutsk, Russian Federation, 669079
                    • State Budgetary Healthcare Institution of Moscow "City Clinical Hospital # 24 of Healthcare Department of Moscow" | Moscow, Russian Federation, 127015
                    • State Budgetary Healthcare Institution of Moscow Region "Moscow Regional Clinical Research Institute n.a. M.F. Vladimirskiy" | Moscow, Russian Federation, 129110
                    • State Budgetary Healthcare Institution of Nizhny Novgorod Region "Nizhny Novgorod Regional Clinical Hospital n.a. N.A. | Nizhniy Novgorod, Russian Federation, 603126
                    • State Budgetary Healthcare Institution of the Novosibirsk Region "State Novosibirsk Regional Clinical Hospital" | Novosibirsk, Russian Federation, 630087
                    • State Budgetary Institution of Health of Novosibirsk Region "City Clinical Hospital #12" | Novosibirsk, Russian Federation, 630091
                    • Saint Petersburg State Budgetary Healthcare Institution "City Polyclinic #38" | Saint-Petersburg, Russian Federation, 191015
                    • "Scientific Research Centre ECO-safety" LLC | Saint-Petersburg, Russian Federation, 196143
                    • "PolyClinic EXPERT" LLC | Saint-Petersburg, Russian Federation, 197110
                    • State Healthcare Institution "Regional Clinical Hospital" | Saratov, Russian Federation, 410053
                    • Clinical Center of Serbia | Belgrade, Serbia, 11000
                    • Clinical Hospital Center Zemun | Belgrade, Serbia, 11000
                    • University Hospital Medical Center Bezanijska kosa | Belgrade, Serbia, 3010-777
                    • Zvezdara University Medical Center | Belgrade, Serbia, 3810-969
                    • Clinical Center of Vojvodina | Novi Sad, Serbia, 21000
                    • National University Hospital | Singapore, Singapore, 119074
                    • Singapore General Hospital | Singapore, Singapore, 169608
                    • Tan Tock Seng Hospital | Singapore, Singapore, 308433
                    • Changi General Hospital | Singapore, Singapore, 529889
                    • Cliniq s. r. o., Gastroenterologicke centrum Ruzinov | Bratislava, Slovakia, 82007
                    • KM Management, s.r.o., Gastroenterologicke a hepatologicke centrum Nitra | Nitra, Slovakia, 950 01
                    • Gastro I., s.r.o. | Presov, Slovakia, 8001
                    • Dr MJ Prins | Cape Town, South Africa, 7500
                    • Dr John P Wright | Cape Town, South Africa, 7708
                    • Peermed Clinical Trial Centre | Johannesburg, South Africa, 1619
                    • Hospital Universitari Germans Trias i Pujol | Badalona, Spain, 08916
                    • Centro Medico Teknon | Barcelona, Spain, 08022
                    • Hospital del Mar | Barcelona, Spain, 8003
                    • Complejo Hospitalario Universitario de Ferrol | Ferrol, Spain, 15405
                    • Hospital Universitario de Gran Canaria "Dr. Negrin" | Las Palmas de Gran Canaria, Spain, 35010
                    • Hospital General Universitario Gregorio Maranon | Madrid, Spain, 28007
                    • Hospital Clinico San Carlos | Madrid, Spain, 28040
                    • Hospital Universitario de Fuenlabrada | Madrid, Spain, 28942
                    • Hospital Universitario Central de Asturias | Oviedo, Spain, 33006
                    • Complejo Hospitalario Universitario de Pontevedra | Pontevedra, Spain, 36071
                    • Hospital de Sagunto | Sagunto, Spain, 46520
                    • Hospital Universitario Virgen del Rocio | Sevilla, Spain, 41013
                    • Hospital de Galdakao-Usandolo | Usansolo, Spain, 48960
                    • National Hospital of Sri Lanka | Colombo, Sri Lanka, 00700
                    • Teaching hospital Karapitiya | Galle, Sri Lanka, 80000
                    • Kandy Teaching Hospital | Kandy, Sri Lanka, 20000
                    • Colombo North Teaching Hospital | Ragama, Sri Lanka, 11010
                    • Danderyds Sjukhus AB | Danderyd, Sweden, SE-18288
                    • Akademiska Sjukhuset | Uppsala, Sweden, 75185
                    • Gastroenterologische Praxis Balsiger, Seibold und Partner | Bern, Switzerland, 3012
                    • Universitatsspital Zurich | Zurich, Switzerland, 8091
                    • Changhua Christian Hospital | Changhua, Taiwan, 500
                    • Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung, Taiwan, 807
                    • Far Eastern Memorial Hospital | New Taipei City, Taiwan, 220
                    • Chang Shan Medical University Hospital | Taichung, Taiwan, 40201
                    • China Medical University Hospital | Taichung, Taiwan, 40447
                    • National Cheng Kung University Hospital | Tainan City, Taiwan, 7428
                    • National Taiwan University Hospital | Taipei, Taiwan, 100
                    • Mackay Memorial Hospital, Taipei | Taipei, Taiwan, 104
                    • Taipei Veterans General Hospital | Taipei, Taiwan, 112
                    • Tri-Service General Hospital | Taipei, Taiwan, 114
                    • Chang Gung Medical Foundation, Chang Gung Memorial Hospital, Linkou Branch | Taoyuan, Taiwan, 33305
                    • Bukovinian State Medical University | Chernivtsi, Ukraine, 58000
                    • Municipal City Clinical Hospital of the Emergency Medical Care, 1 st Therapy Department. Danylo Halytsky Lviv National Medical | Chernivtsi, Ukraine, 58000
                    • State Institution "Institute of Gastroenterology of National Academy of Medical Sciences of Ukraine" | Dnipropetrovsk, Ukraine, 49000
                    • Ivanto-Frankivsk Central City Clinic Hospital, Therapy Department #1. State Higher Education Institution Ivano-Frankivsk National | Ivano-Frankivsk, Ukraine, 76018
                    • Municipal Health Care Institution "Kharkiv City Clinical Hospital #2 named after prof. O. O. Shalimov", Proctology Department | Kharkiv, Ukraine, 61037
                    • Municipal Institution of Health Care "Regional Hospital of War Veterans", Therapeutic Department No1 | Kharkiv, Ukraine, 63101
                    • Treatment and Diagnostic Center of Private Enterprise of Private Production Company "Acinus" | Kropyvnytskyi, Ukraine, 25006
                    • Kyiv City Clinical Hospital No. 18, Proctology Department | Kyiv, Ukraine, 01030
                    • Municipal Non-profit Enterprise "Consultative and Diagnostic Center" of Pechersk District of Kyiv, Therapy Department | Kyiv, Ukraine, 1103
                    • Municipal Institution "Odesa Regional Clinical Hospital", Regional Gastroenterology Center based on Surgery Department | Odessa, Ukraine, 65025
                    • Ternopil University Hospital, Regional Center of Gastroenterology with Hepatology | Ternopil, Ukraine, 46002
                    • Municipal Institution "Uzhgorod District Hospital", Therapy Department | Uzhgorod, Ukraine, 88009
                    • Vinnytsia Regional Clinical Hospital of War Veterans, Therapy Department #1 | Vinnytsia, Ukraine, 21005
                    • Medical Center LLC "Health Clinic" | Vinnytsia, Ukraine, 21009
                    • M.I. Pyrogov Vinnytsia Regional Clinical Hospital, Gastroenterology Department | Vinnytsia, Ukraine, 21018
                    • Municipal Institution "Zaporizhzhya Regional Clinical Hospital" of Zaporizhzhya Regional Council | Zaporizhzhya, Ukraine, 69600
                    • Norfolk and Norwich University Hospital NHS Foundation Trust | Norwich, Norfolk, United Kingdom, NR4 7UY
                    • Queen Elizabeth Hospital | Birmingham, United Kingdom, B15 2WB
                    • The Pennine Acute Hospitals NHS Trust | Bury, United Kingdom, BL9 7TD
                    • Cambridge University Hospital NHS Foundation Trust | Cambridge, United Kingdom, CB2 0QQ
                    • Royal Derby Hospital | Derby, United Kingdom, DE22 3NE
                    • NHS Lothian | Edinburgh, United Kingdom, EH4 2XU
                    • Medical Outpatient Department | Exeter, United Kingdom, EX2 5DW
                    • Glasgow Clinical Research Facility - Queen Elizabeth University Hospital | Glasgow, United Kingdom, G51 4TF
                    • NHS Greater Glasgow and Clyde | Glasgow, United Kingdom, G52 3NQ
                    • Wycombe Hospital | High Wycombe, United Kingdom, HP11 2TT
                    • Hull Royal Infirmary | Hull, United Kingdom, HU3 2JZ
                    • Imperial College Healthcare NHS Trust, St Mary's Hospital | London, United Kingdom, W2 1NY
                    • Oxford University Hospitals NHS Foundation Trust | Oxford, United Kingdom, OX3 9DU
                    • St Helens and Knowsley Teaching Hospitals NHS Trust | Prescot, United Kingdom, L35 5DR
                    • Southampton National Institute for Health Research, Wellcome Trust Clinical Research Facility | Southampton, United Kingdom, SO16 6YD
                    Investigators

                      Study Documents (Full Text)

                      More Information

                      Additional Relevant MeSH Terms

                      • Crohn Disease
                      • Inflammatory Bowel Diseases
                      • Gastroenteritis
                      • Gastrointestinal Diseases
                      • Digestive System Diseases
                      • Intestinal Diseases