A Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Crohn's Disease Who Completed the Studies M14-431 or M14-433

ClinicalTrials.gov processed this data on June 13, 2024. Link to the current ClinicalTrials.gov record.

Recruitment Status

ACTIVE, NOT RECRUITING (See Contacts and Locations)
Verified June 2024 by AbbVie

Sponsor

AbbVie

Information Provided by (Responsible Party)

AbbVie

Clinicaltrials.gov Identifier

NCT03345823
Other Study ID Numbers: M14-430
First Submitted: November 15, 2017
First Posted: November 17, 2017
Last Update Posted: June 17, 2024
Last Verified: June 2024
History of Changes

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Study Description

Not Provided
Condition or Disease Intervention/Treatment
  • Crohn's Disease
  • Drug: Upadacitinib
  • Drug: Placebo for Upadacitinib

Study Design

Study TypeInterventional
Anticipated Enrollment747 participants
Design AllocationRandomized
Interventional ModelSequential Assignment
MaskingQuadruple
Primary PurposeTreatment
Official TitleA Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Crohn's Disease Who Completed the Studies M14-431 or M14-433
Study Start DateMarch 21, 2018
Anticipated Primary Completion DateSeptember 3, 2027
Anticipated Study Completion DateSeptember 3, 2027

Groups and Cohorts

Group/ CohortIntervention/ Treatment
  • Substudy 1: Cohort 1 Upadacitinib Dose A
    • This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose A for 52 weeks.
  • Drug: Upadacitinib
    • Oral; Tablet
  • Substudy 1: Cohort 1 Upadacitinib Dose B
    • This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose B for 52 weeks.
  • Drug: Upadacitinib
    • Oral; Tablet
  • Substudy 1: Cohort 1 Placebo
    • This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive placebo for 52 weeks.
  • Drug: Placebo for Upadacitinib
    • Substudy 1: Cohort 2 Placebo
      • This is a maintenance group which includes participants who received double-blind placebo in studies M14-431 and M14-433 and achieved clinical response will continue to receive blinded placebo for 52 Weeks.
    • Drug: Placebo for Upadacitinib
      • Substudy 1: Cohort 3 Upadacitinib Dose B
        • This is a maintenance group which includes participants who achieved clinical response to upadacitinib from the extended treatment period of studies M14-431 and M14-433 and will receive upadacitinib Dose B for 52 Weeks.
      • Drug: Upadacitinib
        • Oral; Tablet
      • Substudy 2: Cohort 4 Upadacitinib Dose B
        • This is a long-term extension group which includes participants who achieved clinical response in the open-label extended treatment period of study M14-431 and will receive upadacitinib dose B for 240 weeks.
      • Drug: Upadacitinib
        • Oral; Tablet
      • Substudy 2: Cohort 5 Upadacitinib Dose A
        • This is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose A for 240 weeks.
      • Drug: Upadacitinib
        • Oral; Tablet
      • Substudy 2: Cohort 5 Upadacitinib Dose B
        • This is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose B for 240 weeks.
      • Drug: Upadacitinib
        • Oral; Tablet
      • Substudy 2: Cohort 5 Placebo
        • This is a long-term extension group which includes participants who complete Substudy 1 and will receive placebo for 240 weeks.
      • Drug: Placebo for Upadacitinib

        Outcome Measures

        Primary Outcome Measures

        1. Sub-Study 1: Percentage of Participants with Clinical Remission per Crohn's Disease Activity Index (CDAI) [Week 52]
          Clinical remission per CDAI is defined as CDAI <150.
        2. Sub-Study 1: Percentage of Participants with Endoscopic Response [Week 52]
          Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) from Baseline.
        3. Number of Participants with Adverse Events [Through Week 240]
          An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either probably related, possibly related, probably not related or not related. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the participant and may require medical or surgical intervention to prevent any of the outcomes listed above. For more details on adverse events please see the Adverse Event section.

        Secondary Outcome Measures

        1. Sub-Study 1: Percentage of Participants with Clinical Remission per Patient-Reported Outcomes (PROs) [Week 52]
          Clinical remission is defined based on average daily stool frequency (SF) AND average daily abdominal pain (AP) score.
        2. Sub-Study 1: Percentage of Participants Achieving Clinical Response 100 (CR-100) [Week 52]
          Decrease of at least 100 points in CDAI from Baseline.
        3. Sub-Study 1: Percentage of Participants with Endoscopic Remission [Week 52]
          Endoscopic remission is defined per Simplified Endoscopic Score for Crohn's Disease (SES-CD).
        4. Sub-Study 1: Percentage of Participants without Corticosteroid use for Crohn's Disease Among All Participants [Week 52]
          This is assessed in participants not taking corticosteroids at least 90 days prior to Week 52 and achieved clinical remission per CDAI. Clinical remission is defined as CDAI <150.
        5. Sub-Study 1: Percentage of Participants with Clinical Remission per CDAI and Endoscopic Remission [Week 52]
          Clinical remission per CDAI is defined as CDAI <150. Endoscopic remission is defined per SES-CD.
        6. Sub-Study 1: Percentage of Participants with Clinical Remission per CDAI [Through Week 52]
          Clinical remission per CDAI is defined as CDAI <150 (as measured by the percentage of participants with clinical remission at Week 52 among those with clinical remission at Week 0).
        7. Sub-Study 1: Percentage of Participants who Discontinue Corticosteroid Use for Crohn's Disease at Least 90 Days Prior to Week 52 and Achieve Clinical Remission, in Participants Taking Corticosteroids at Baseline. [Week 52]
          This is assessed in participants taking corticosteroids at Baseline. Clinical remission is defined based on average daily stool frequency (SF) AND average daily abdominal pain (AP) score.
        8. Sub-Study 1: Change in Inflammatory Bowel Disease Questionnaire (IBDQ) [Baseline (Week 0) to Week 52]
          The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
        9. Sub-Study 1: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) [Baseline (Week 0) to Week 52]
          The FACIT-F questionnaire was developed to assess fatigue.
        10. Sub-Study 1: Percentage of Participants with Hospitalizations due to Crohn's Disease (CD) [Up to Week 52]
          This is assessed by reviewing participant's hospitalization data.
        11. Sub-Study 1: Percentage of Participants with Resolution of Extra-Intestinal Manifestation (EIMs) , in Participants with EIMs at Baseline [Week 52]
          EIMs are defined as manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.

        Eligibility Criteria

        Ages Eligible for Study 18 Years to 75 Years (Adult, Older Adult)
        Sexes Eligible for Study All
        Accepts Healthy Volunteers No
        Inclusion Criteria
        • For Substudy 1:
        • Participant who achieve clinical response in Study M14-431 or Study M14-433.
        • Participant completes study procedures in the parent study. The final endoscopy for Studies M14-431 or M14-433 may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
        • For Substudy 2:
        • Participant completes Substudy 1. The Week 52 endoscopy may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
        • Participant who achieved clinical response at the time described in the protocol and completes study procedures in the parent study/ substudy.
        Exclusion Criteria
        • For Substudies 1 and 2:
        • Participant is considered by the investigator, for any reason, to be an unsuitable candidate for the study.
        • Participant who has a known hypersensitivity to upadacitinib or its excipients, or had an adverse event during Studies M14-431 and M14-433 or Substudy 1 or 2 of Study M14-430 that in the investigator's judgment makes the participant unsuitable for this study.
        • Participant at the final visit of M14-431 or M14-433 with any active or chronic recurring infections based on the investigator's assessment that makes the participant an unsuitable candidate for the study. Participants with serious infections undergoing treatment may be enrolled BUT NOT dosed until the infection treatment has been completed and the infection is resolved, based on the investigator's assessment.
        • Participants with high grade colonic dysplasia or malignancy diagnosed at the endoscopy performed at the final visit of Studies M14-431, M14-433 or Substudy 1 of Study M14-430 (Week 52).

        Contacts and Locations

        Sponsors and Collaborators AbbVie
        Locations
        • East View Medical Research, LLC /ID# 171132 | Mobile, Alabama, United States, 36606
        • CB Flock Research Corporation /ID# 166239 | Mobile, Alabama, United States, 36608
        • Delsol Research Management, Ll /Id# 170164 | Chandler, Arizona, United States, 85224
        • HonorHealth Research Institute - Shea /ID# 164725 | Scottsdale, Arizona, United States, 85258
        • Arizona Arthritis & Rheumatology Research, PLLC /ID# 164702 | Sun City, Arizona, United States, 85306
        • Southern California Res. Ctr. /ID# 169653 | Coronado, California, United States, 92118-1408
        • Citrus Valley Gastroenterology /ID# 166230 | Covina, California, United States, 91722-3797
        • Hoag Memorial Hosp Presbyterian /ID# 222538 | Irvine, California, United States, 92618
        • UC San Diego Health System /ID# 164763 | La Jolla, California, United States, 92037
        • United Medical Doctors /ID# 207458 | Los Alamitos, California, United States, 90720-3309
        • Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164640 | Los Angeles, California, United States, 90067-2001
        • Facey Medical Foundation /ID# 203138 | Mission Hills, California, United States, 91345
        • United Medical Doctors - Murrieta /ID# 164602 | Murrieta, California, United States, 92563
        • Medical Assoc Research Grp /ID# 169704 | San Diego, California, United States, 92123
        • UCSF Medical Center - Mount Zion /ID# 202372 | San Francisco, California, United States, 94115
        • Univ of California San Francis /ID# 164653 | San Francisco, California, United States, 94158
        • Care Access Research /ID# 167765 | San Pablo, California, United States, 94806
        • Peak Gastroenterology Associates, PC /ID# 170166 | Colorado Springs, Colorado, United States, 80907
        • Delta Waves, Inc. /ID# 164656 | Colorado Springs, Colorado, United States, 80918
        • Western States Clinical Res /ID# 164625 | Wheat Ridge, Colorado, United States, 80033-2896
        • Gastroenterology Center of Connecticut /ID# 164614 | Hamden, Connecticut, United States, 06518
        • Advanced Research - Coral Springs /ID# 218019 | Coral Springs, Florida, United States, 33067-3173
        • Encore Borland-Groover Clinical Research /Id# 203500 | Jacksonville, Florida, United States, 32256
        • Ctr for Advanced Gastroenterol /ID# 165306 | Maitland, Florida, United States, 32751-6108
        • Crystal Pharmacology Research /ID# 166118 | Miami, Florida, United States, 33165
        • Coral Research Clinic /ID# 164604 | Miami, Florida, United States, 33186-4643
        • Advanced Research Institute, Inc /ID# 164601 | New Port Richey, Florida, United States, 34653
        • Endoscopic Research, Inc. /ID# 206139 | Orlando, Florida, United States, 32803
        • Omega Research Group /ID# 203482 | Orlando, Florida, United States, 32808
        • Clinical Research of West Florida, Inc /ID# 205828 | Tampa, Florida, United States, 33606-1246
        • Clinical Research of West Florida, Inc /ID# 208119 | Tampa, Florida, United States, 33606-1246
        • Clinical Research Trials of Florida, Inc. /ID# 203486 | Tampa, Florida, United States, 33607
        • Duplicate_AdventHealth Tampa /ID# 171181 | Tampa, Florida, United States, 33613-4680
        • Gastroenterology Associates of Central Georgia, LLC /ID# 165492 | Macon, Georgia, United States, 31201
        • Gastroenterology Consultants, P.C /ID# 218218 | Roswell, Georgia, United States, 30076-4913
        • Atlanta Gastroenterology Spec /ID# 164698 | Suwanee, Georgia, United States, 30024
        • Treasure Valley Medical Research /ID# 215030 | Boise, Idaho, United States, 83706
        • Duplicate_Rush University Medical Center /ID# 165470 | Chicago, Illinois, United States, 60612
        • University of Chicago Medicine /ID# 165509 | Chicago, Illinois, United States, 60637-1426
        • DuPage Medical Group /ID# 205320 | Downers Grove, Illinois, United States, 60515-5509
        • MediSphere Medical Research Center /ID# 166233 | Evansville, Indiana, United States, 47714-8011
        • Indianapolis Gastroenterology /ID# 164649 | Indianapolis, Indiana, United States, 46237
        • Aquiant Research /ID# 205505 | New Albany, Indiana, United States, 47150-4053
        • University of Iowa Hospitals and Clinics /ID# 165405 | Iowa City, Iowa, United States, 52242
        • Tri-State Gastroenterology /ID# 165469 | Crestview Hills, Kentucky, United States, 41017
        • Duplicate_University of Louisville /ID# 165391 | Louisville, Kentucky, United States, 40202
        • University of Louisville Hospital /ID# 168520 | Louisville, Kentucky, United States, 40202
        • Houma Digestive Health Special /ID# 164727 | Houma, Louisiana, United States, 70360
        • Nola Research Works, LLC /ID# 164612 | New Orleans, Louisiana, United States, 70115
        • Louisiana Research Center, LLC /ID# 164694 | Shreveport, Louisiana, United States, 71105-6800
        • Duplicate_Johns Hopkins University School of Medicine /ID# 211939 | Baltimore, Maryland, United States, 21287-0010
        • Metropolitan Gastroenterology Group - Chevy Chase /ID# 164647 | Chevy Chase, Maryland, United States, 20815
        • Gastro Center of Maryland /ID# 171180 | Columbia, Maryland, United States, 21045
        • Duplicate_Lahey Hospital and Medical Center /ID# 214724 | Burlington, Massachusetts, United States, 01805
        • University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164654 | Ann Arbor, Michigan, United States, 48109
        • Clin Res Inst of Michigan, LLC /ID# 170163 | Chesterfield, Michigan, United States, 48047
        • Digestive Health Associates (DHA) - Farmington Hills /ID# 206101 | Farmington Hills, Michigan, United States, 48334-3230
        • Center for Digestive Health /ID# 164726 | Troy, Michigan, United States, 48098-6363
        • Mayo Clinic - Rochester /ID# 164691 | Rochester, Minnesota, United States, 55905-0001
        • Southern Therapy and Advanced Research (STAR) LLC /ID# 165295 | Jackson, Mississippi, United States, 39216
        • Quality Clinical Research Inc. /ID# 170162 | Omaha, Nebraska, United States, 68114-3723
        • CHI Health Research Center /ID# 168513 | Omaha, Nebraska, United States, 68124
        • Las Vegas Medical Research /ID# 168551 | Las Vegas, Nevada, United States, 89113
        • Cooper Gastroenterology at Fire Road /ID# 164641 | Egg Harbor Township, New Jersey, United States, 08234
        • Rutgers Robert Wood Johnson /ID# 166110 | New Brunswick, New Jersey, United States, 08901
        • Montefiore Medical Center - Moses Campus /ID# 166242 | Bronx, New York, United States, 10467
        • Advantage Clinical Trials /ID# 168582 | Bronx, New York, United States, 10468
        • NY Scientific /ID# 164630 | Brooklyn, New York, United States, 11235
        • United Health Services Hospitals, Inc /ID# 217483 | Johnson City, New York, United States, 13790-2107
        • NYU Langone Long Island Clinical Research Associates /ID# 164627 | Lake Success, New York, United States, 11042
        • The Mount Sinai Hospital /ID# 170256 | New York, New York, United States, 10029
        • Columbia Univ Medical Center /ID# 164692 | New York, New York, United States, 10032-3725
        • Gastoenterology Group of Rochester /ID# 166235 | Rochester, New York, United States, 14618-5703
        • Richmond University Medical Center /ID# 201858 | Staten Island, New York, United States, 10310-1664
        • Atrium Health Carolinas Medical Center /ID# 164632 | Charlotte, North Carolina, United States, 28203
        • PMG Research of Charlotte /ID# 171178 | Charlotte, North Carolina, United States, 28209
        • Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164752 | Raleigh, North Carolina, United States, 27612
        • Atrium Health Wake Forest Baptist Medical Center /ID# 164755 | Winston-Salem, North Carolina, United States, 27157-0001
        • Plains Clinical Research Center, LLC /ID# 170169 | Fargo, North Dakota, United States, 58104-5925
        • Gastro Health Research /ID# 164668 | Cincinnati, Ohio, United States, 45219
        • University of Cincinnati /ID# 164729 | Cincinnati, Ohio, United States, 45267-0585
        • Cleveland Clinic Main Campus /ID# 209230 | Cleveland, Ohio, United States, 44195
        • Ohio State University/ Gastroe /ID# 170159 | Columbus, Ohio, United States, 43210
        • Optimed Research, Ltd. /ID# 205625 | Columbus, Ohio, United States, 43235
        • Hometown Urgent Care and Resea /ID# 201289 | Dayton, Ohio, United States, 45424
        • Dayton Gastroenterology, Inc. /ID# 167623 | Englewood, Ohio, United States, 45415
        • Great Lakes Gastroenterology Research, LLC /ID# 202006 | Mentor, Ohio, United States, 44060-6211
        • Digestive Disease Specialists /ID# 201063 | Oklahoma City, Oklahoma, United States, 73112
        • Options Health Research, LLC /ID# 164704 | Tulsa, Oklahoma, United States, 74104
        • Healthcare Research Consultant /ID# 166244 | Tulsa, Oklahoma, United States, 74135
        • University of Pennsylvania /ID# 168406 | Philadelphia, Pennsylvania, United States, 19104-5502
        • Duplicate_Thomas Jefferson University /ID# 168003 | Philadelphia, Pennsylvania, United States, 19107-4414
        • Pharmacorp Clinical Trials /ID# 165008 | Charleston, South Carolina, United States, 29412
        • Gastroenterology Associates, P.A. of Greenville /ID# 164643 | Greenville, South Carolina, United States, 29607
        • Rapid City Medical Center - GI Research /ID# 201733 | Rapid City, South Dakota, United States, 57701
        • Gastro One /ID# 164730 | Cordova, Tennessee, United States, 38018
        • East Tennessee Research Institute /ID# 203614 | Johnson City, Tennessee, United States, 37604
        • Quality Medical Research /ID# 205264 | Nashville, Tennessee, United States, 37211
        • Vanderbilt University Medical Center /ID# 164607 | Nashville, Tennessee, United States, 37232-0011
        • TX Clinical Research Institute /ID# 164719 | Arlington, Texas, United States, 76012
        • Inquest Clinical Research /ID# 164676 | Baytown, Texas, United States, 77521-2415
        • Texas Digestive Disease Consultants /ID# 209954 | Cedar Park, Texas, United States, 78613-5028
        • GI Alliance /ID# 209803 | Cedar Park, Texas, United States, 78613
        • Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170161 | Dallas, Texas, United States, 75246
        • Baylor College of Medicine /ID# 164609 | Houston, Texas, United States, 77030
        • Centex Studies, Inc. - Houston /ID# 201212 | Houston, Texas, United States, 77058
        • GI Specialists of Houston /ID# 202340 | Houston, Texas, United States, 77070-4347
        • Caprock Gastro Research - Lubbock - 80th Street /ID# 215436 | Lubbock, Texas, United States, 79424
        • Clinical Associates in Research Therapeutics of America, LLC /ID# 164675 | San Antonio, Texas, United States, 78212
        • Southern Star Research Institute, LLC /ID# 169756 | San Antonio, Texas, United States, 78229-5390
        • Carl R. Meisner Medical Clinic /ID# 171057 | Sugar Land, Texas, United States, 77478
        • Tyler Research Institute, LLC /ID# 168679 | Tyler, Texas, United States, 75701
        • Gastro Health & Nutrition - Victoria /ID# 167810 | Victoria, Texas, United States, 77904
        • HP Clinical Research /ID# 164631 | Bountiful, Utah, United States, 84010
        • Advanced Research Institute /ID# 164689 | Ogden, Utah, United States, 84405
        • Duplicate_Care Access Research /ID# 164685 | Salt Lake City, Utah, United States, 84124-1377
        • Velocity Clinical Research - Salt Lake City /ID# 166113 | West Jordan, Utah, United States, 84088
        • Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 164728 | Bellevue, Washington, United States, 98004
        • Virginia Mason Hospital & Medical Center /ID# 164862 | Seattle, Washington, United States, 98101
        • University of Washington /ID# 164646 | Seattle, Washington, United States, 98109
        • The Vancouver Clinic, INC. PS /ID# 164874 | Vancouver, Washington, United States, 98664
        • Froedtert Memorial Lutheran Hospital /ID# 202285 | Milwaukee, Wisconsin, United States, 53226-3522
        • Allegiance Research Specialists /ID# 165298 | Wauwatosa, Wisconsin, United States, 53226
        • Cardio Alem /ID# 211283 | San Isidro, Buenos Aires, Argentina, 1642
        • Hospital Italiano de Buenos Aires /ID# 215542 | Ciudad Autonoma Buenos Aires, Ciudad Autonoma De Buenos Aires, Argentina, 1199
        • Gedyt /ID# 210018 | Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina, 1115
        • Cemic /Id# 169183 | Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina, 1431
        • Hospital Provincial del Centenario /ID# 171251 | Rosario, Santa Fe, Argentina, 2000
        • Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 169229 | Cordoba, Argentina, 5016
        • Concord Repatriation General Hospital /ID# 171506 | Concord, New South Wales, Australia, 2139
        • Coral Sea Clinical Research institute /ID# 212989 | North Mackay, Queensland, Australia, 4740
        • Mater Misericordiae Limited /ID# 204910 | South Brisbane, Queensland, Australia, 4101
        • Royal Adelaide Hospital /ID# 171508 | Adelaide, South Australia, Australia, 5000
        • Box Hill Hospital /ID# 203735 | Box Hill, Victoria, Australia, 3128
        • Fiona Stanley Hospital /ID# 171507 | Murdoch, Western Australia, Australia, 6150
        • Klinik Landstrasse /ID# 203438 | Vienna, Wien, Austria, 1030
        • Medizinische Universitaet Wien /ID# 169459 | Vienna, Wien, Austria, 1090
        • Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 214468 | Salzburg, Austria, 5020
        • Cliniques Universitaires UCL Saint-Luc /ID# 200293 | Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium, 1200
        • CHU de Liège /ID# 200294 | Liège, Liege, Belgium, 4000
        • Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 200295 | Yvoir, Namur, Belgium, 5530
        • Duplicate_AZ Sint-Lucas /ID# 200296 | Gent, Oost-Vlaanderen, Belgium, 9000
        • Universitair Ziekenhuis Leuven /ID# 200031 | Leuven, Vlaams-Brabant, Belgium, 3000
        • Duplicate_University Clinical Centre of the Republic of Srpska /ID# 200743 | Banja Luka, Republika Srpska, Bosnia and Herzegovina, 78000
        • University Clinical Center Tuzla /ID# 210323 | Tuzla, Tuzlanski, Bosnia and Herzegovina, 75000
        • Clinical Center University of Sarajevo /ID# 201346 | Sarajevo, Bosnia and Herzegovina, 71000
        • Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217843 | Sarajevo, Bosnia and Herzegovina, 71000
        • Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166853 | Goiânia, Goias, Brazil, 74535-170
        • Faculdade de Medicina do ABC /ID# 166854 | Santo André, La Spezia, Brazil, 09060-870
        • Hospital Nossa Senhora das Graças /ID# 166856 | Curitiba, Parana, Brazil, 80810-040
        • Hospital de Clinicas de Porto Alegre /ID# 166855 | Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
        • Upeclin Fmb - Unesp /Id# 166860 | Botucatu, Sao Paulo, Brazil, 18618-686
        • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 166859 | Ribeirão Preto, Sao Paulo, Brazil, 14049-900
        • Kaiser Clinica e Hospital Dia /ID# 166858 | Sao Jose Do Rio Preto, Sao Paulo, Brazil, 15015-110
        • UMHAT Kaspela EOOD /ID# 167615 | Plovdiv, Bulgaria, 4001
        • Duplicate_Second MHAT Sofia /ID# 167616 | Sofia, Bulgaria, 1202
        • MHAT Trakia /ID# 201677 | Stara Zagora, Bulgaria, 6004
        • University of Calgary /ID# 166990 | Calgary, Alberta, Canada, T2N 4Z6
        • Allen Whey Khye Lim Professional Corporation /ID# 168047 | Edmonton, Alberta, Canada, T5R 1W2
        • University of Alberta Hospital /ID# 166987 | Edmonton, Alberta, Canada, T6G 2B7
        • Covenant Health /ID# 166996 | Edmonton, Alberta, Canada, T6K 4B2
        • Fraser Clinical Trials Inc /ID# 166984 | New Westminster, British Columbia, Canada, V3L 3W4
        • GIRI Gastrointestinal Research Institute /ID# 166994 | Vancouver, British Columbia, Canada, V6Z 2K5
        • QEII - Health Sciences Centre /ID# 169308 | Halifax, Nova Scotia, Canada, B3H 2Y9
        • London Health Sciences Center- University Hospital /ID# 221039 | London, Ontario, Canada, N6A 5W9
        • Scott Shulman Medicine Professional Corporation /ID# 169065 | North Bay, Ontario, Canada, P1B 2H3
        • Taunton surgical centre /ID# 168045 | Oshawa, Ontario, Canada, L1H 7K4
        • Ottawa Hospital Research Institute /ID# 212412 | Ottawa, Ontario, Canada, K1H 8L6
        • Medicor Research Inc /ID# 166997 | Sudbury, Ontario, Canada, P3A 1W8
        • Toronto Digestive Disease Associates, Inc. /ID# 166988 | Vaughan, Ontario, Canada, L4L 4Y7
        • Hotel Dieu de Levis /ID# 166985 | Lévis, Quebec, Canada, G6V 3Z1
        • Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 170122 | Montreal, Quebec, Canada, H2X 0A9
        • Royal Victoria Hospital / McGill University Health Centre /ID# 170011 | Montreal, Quebec, Canada, H4A 3J1
        • CIUSSS de l'Estrie - CHUS /ID# 170936 | Sherbrooke, Quebec, Canada, J1G 2E8
        • Research Group /ID# 203178 | Santiago, Region Metropolitana De Santiago, Chile, 2540364
        • Hospital Guillermo Grant Benavente de Concepción /ID# 212421 | Concepción, Chile, 4070038
        • CTR Estudios Clinicos /ID# 203940 | Providencia, Chile, 7500571
        • Hospital Clinico Universidad De Los Andes /ID# 207463 | Santiago, Chile, 7501504
        • CEC SpA /ID# 169872 | Ñuñoa, Chile, 7750495
        • Beijing Friendship Hospital /ID# 204175 | Beijing, Beijing, China, 100032
        • Zhongshan Hospital Xiamen University /ID# 204986 | Xiamen, Fujian, China, 361004
        • The First Affiliated Hospital, Sun Yat-sen University /ID# 205227 | Guangzhou, Guangdong, China, 510080
        • Nanfang Hospital of Southern Medical University /ID# 204056 | Guangzhou, Guangdong, China, 510515
        • The Sixth Affiliated Hosp Sun /ID# 204054 | Guangzhou, Guangdong, China, 510655
        • Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204065 | Wuhan, Hubei, China, 430022
        • Tongji Hospital Tongji Medical College of HUST /ID# 204051 | Wuhan, Hubei, China, 430030
        • Nanjing Drum Tower Hospital /ID# 204899 | Nanjing, Jiangsu, China, 210008
        • The First Affiliated Hospital of Nanchang University /ID# 204052 | Nanchang, Jiangxi, China, 330006
        • The First Hospital of Jilin University /ID# 206865 | Changchun, Jilin, China, 130021
        • Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204055 | Shanghai, Shanghai, China, 200065
        • The second affiliated hospital of Zhejiang University school of medicine /ID# 204058 | Hangzhou, Zhejiang, China, 310009
        • Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204050 | Hangzhou, Zhejiang, China, 310018
        • The Second Xiangya Hospital of Central South University /ID# 204057 | Changsha, China, 410011
        • Duplicate_Tianjin Med Univ General Hosp /ID# 206979 | Tianjin, China, 300052
        • Hospital San Vicente de Paul /ID# 200020 | Medellin, Antioquia, Colombia, 50034
        • Duplicate_Hospital Pablo Tobon Uribe /ID# 202403 | Medellín, Antioquia, Colombia, 50034
        • Clinical Hospital Dubrava /ID# 171165 | Zagreb, Grad Zagreb, Croatia, 10000
        • Klinicki bolnicki centar Sestre milosrdnice /ID# 171194 | Zagreb, Grad Zagreb, Croatia, 10000
        • Klinicki bolnicki centar Zagreb /ID# 171168 | Zagreb, Grad Zagreb, Croatia, 10000
        • Poliklinika Solmed /ID# 211517 | Grad Zagreb, Croatia, 10000
        • UHC Split /ID# 171205 | Split, Croatia, 21000
        • Zadar General Hospital /ID# 205533 | Zadar, Croatia, 23000
        • Nemocnice Ceske Budejovice a.s. /ID# 224390 | Ceske Budejovice, Czechia, 370 01
        • Hepato-Gastroenterologie HK, s.r.o. /ID# 171564 | Hradec Kralove, Czechia, 500 12
        • ARTROSCAN s.r.o. /ID# 171575 | Ostrava, Czechia, 722 00
        • ResTrial s.r.o. /ID# 208651 | Praha, Czechia, 143 00
        • Herlev Hospital /ID# 200785 | Herlev, Hovedstaden, Denmark, 2730
        • Nordsjaellands Hospital /ID# 200788 | Hilleroed, Hovedstaden, Denmark, 3600
        • Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 200787 | Hvidovre, Hovedstaden, Denmark, 2650
        • Duplicate_Sjaellands Universitets Hospital /ID# 200786 | Roskilde, Sjælland, Denmark, 4000
        • Alexandria University /ID# 171008 | Alexandria, Egypt, 21131
        • Alexandria University /ID# 171017 | Alexandria, Egypt, 21131
        • Duplicate_Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 209561 | Alexandria, Egypt, 21131
        • National Hepatology and Tropical Medicine Research Institute /ID# 170991 | Cairo, Egypt, 11559
        • Ain Shams University Faculty of Medicine /ID# 209566 | Cairo, Egypt, 11566
        • Air Force Specialized Hospital /ID# 170993 | Cairo, Egypt,
        • National Liver Institute /ID# 170987 | Menoufiya, Egypt, 35111
        • Tartu University Hospital /ID# 203141 | Tartu Linn, Tartumaa, Estonia, 50406
        • West Tallinn Central Hospital /ID# 202787 | Tallinn, Estonia, 10617
        • Chu de Nice-Hopital Larchet Ii /Id# 171004 | Nice, Alpes-Maritimes, France, 06200
        • Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 207812 | Pessac, Gironde, France, 33604
        • CHU Toulouse - Hopital Rangueil /ID# 169784 | Toulouse, Haute-Garonne, France, 31400
        • Duplicate_Hopital Saint Eloi /ID# 170039 | Montpellier CEDEX 5, Herault, France, 34295
        • Hopital Beaujon /ID# 171007 | Clichy, Ile-de-France, France, 92110
        • Duplicate_CHU Grenoble - Hopital Michallon /ID# 222403 | La Tronche, Isere, France, 38700
        • CHRU Nancy - Hopitaux de Brabois /ID# 170970 | Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France, 54500
        • CHRU Lille - Hopital Claude Huriez /ID# 206653 | Lille, Nord, France, 59037
        • CH Valenciennes /ID# 222399 | Valenciennes, Nord, France, 59300
        • HCL - Hopital Lyon Sud /ID# 171030 | Pierre Benite CEDEX, Rhone, France, 69495
        • CHU Amiens-Picardie Site Sud /ID# 171023 | Amiens CEDEX 1, Somme, France, 80054
        • CHRU Tours - Hopital Trousseau /ID# 169783 | Chambray Les Tours, France, 37170
        • Duplicate_CHU Henri Mondor /ID# 169782 | Creteil, France, 94000
        • Clinique Jules Verne /ID# 222240 | Nantes, France, 44300
        • Polyclinique Grand Sud /ID# 170037 | Nimes Cedex, France, 30932
        • Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 171027 | St-Priest-en-Jarez, France, 42270
        • Universitatsklinikum Mannheim /ID# 168754 | Mannheim, Baden-Wuerttemberg, Germany, 68167
        • Universitaetsklinikum Ulm /ID# 203554 | Ulm, Baden-Wuerttemberg, Germany, 89081
        • Universitaetsklinikum Erlangen /ID# 203550 | Erlangen, Bayern, Germany, 91054
        • Duplicate_Agaplesion Markus Krankenhaus /ID# 168753 | Frankfurt am Main, Hessen, Germany, 60431
        • Universitaetsklinikum Frankfurt /ID# 203567 | Frankfurt am Main, Hessen, Germany, 60590
        • Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206739 | Saarbrücken, Saarland, Germany, 66111
        • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168755 | Kiel, Schleswig-Holstein, Germany, 24105
        • Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 169271 | Berlin, Germany, 12203
        • Gastroenterologie am Mexikoplatz /ID# 203574 | Berlin, Germany, 14163
        • Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203569 | Essen, Germany, 45239
        • Universitaetsklinikum Halle (Saale) /ID# 207453 | Halle (Saale), Germany, 06120
        • Medizinisches Versorgungszentrum Portal 10 /ID# 200212 | Muenster, Germany, 48155
        • General Hospital of Athens Ippokratio /ID# 167032 | Athens, Attiki, Greece, 11527
        • General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202102 | Athens, Attiki, Greece, 11527
        • Tzaneio general hospital of Piraeus /ID# 206435 | Piraeus, Attiki, Greece, 18536
        • University General Hospital of Heraklion PA.G.N.I /ID# 167031 | Heraklion, Kriti, Greece, 71500
        • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 167033 | Athens, Greece, 10676
        • General Hospital of Thessaloniki Hippokrateio /ID# 208823 | Thessaloniki, Greece, 54642
        • Queen Mary Hospital /ID# 171214 | Hong Kong, Hong Kong, 999077
        • Tuen Mun Hospital /ID# 171213 | Hong Kong, Hong Kong,
        • Pecsi Tudomanyegyetem Klinikai Kozpont Mohacsi Korhaz /ID# 209440 | Mohacs, Baranya, Hungary, 7700
        • CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205549 | Encs, Borsod-Abauj-Zemplen, Hungary, 3860
        • Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 216420 | Debrecen, Hajdu-Bihar, Hungary, 4032
        • Gyongyosi Bugat Pal Korhaz /ID# 201885 | Gyongyos, Heves, Hungary, 3200
        • Komarom-Esztergom Varmegyei Szent Borbala Korhaz (Clinexpert Tatabanya Kft.) /ID# 209896 | Tatabanya, Komarom-Esztergom, Hungary, 2800
        • Obudai Egeszsegugyi Centrum Kft. /ID# 201886 | Budapest, Hungary, 1036
        • Semmelweis Egyetem /ID# 210166 | Budapest, Hungary, 1085
        • Magyar Honvedseg Egeszsegugyi Kozpont /ID# 200888 | Budapest, Hungary, 1134
        • Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 200887 | Debrecen, Hungary, 4031
        • Kistarcsai Flor Ferenc Korhaz /ID# 206153 | Kistarcsa, Hungary, 2143
        • Mentahaz Maganorvosi Kozpont /ID# 201888 | Szekesfehervar, Hungary, 8000
        • Mercy University Hospital /ID# 206512 | Cork, Ireland, T12 WE28
        • Barzilai Medical Center /ID# 223374 | Ashkelon, HaDarom, Israel, 7830604
        • Soroka University Medical Center /ID# 169911 | Be'er Sheva, HaDarom, Israel, 8443901
        • Duplicate_Kaplan Medical Center /ID# 170275 | Rehovot, HaMerkaz, Israel, 7661041
        • Yitzhak Shamir Medical Center /ID# 206449 | Zerifin, HaMerkaz, Israel, 70300
        • Tel Aviv Sourasky Medical Center /ID# 206450 | Tel Aviv, Tel-Aviv, Israel, 6423906
        • Hadassah Medical Center-Hebrew University /ID# 169926 | Jerusalem, Yerushalayim, Israel, 91120
        • Rabin Medical Center /ID# 202634 | Haifa, Israel, 4941492
        • University of Catanzaro /ID# 201986 | Catanzaro, Calabria, Italy, 88100
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 168150 | Rome, Lazio, Italy, 00168
        • ASST Grande Ospedale Metropolitano Niguarda /ID# 170906 | Milan, Milano, Italy, 20162
        • Istituto Clinico Humanitas /ID# 168153 | Rozzano, Milano, Italy, 20089
        • Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 168151 | Rome, Roma, Italy, 00128
        • Fondazione PTV Policlinico Tor Vergata /ID# 168156 | Rome, Roma, Italy, 00133
        • Azienda Ospedaliera San Camillo Forlanini /ID# 168152 | Rome, Roma, Italy, 00152
        • IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168154 | Negrar, Verona, Italy, 37024
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 168155 | Bologna, Italy, 40138
        • A.O. Per L'Emergenza Cannizzaro /ID# 168161 | Catania, Italy, 95126
        • Policlinico San Martino/Univer /ID# 168162 | Genova, Italy, 16132
        • ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168149 | Milano, Italy, 20121
        • Azienda Ospedaliero-Universitaria di Modena /ID# 200009 | Modena, Italy, 41124
        • A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 168157 | Palermo, Italy, 90146
        • Duplicate_Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202419 | Pisa, Italy, 56125
        • Aichi Medical University /ID# 165989 | Nagakute, Aichi, Japan, 480-1195
        • Nagoya City University Hospital /ID# 165988 | Nagoya shi, Aichi, Japan, 467-8602
        • Nagoya University Hospital /ID# 165987 | Nagoya-shi, Aichi, Japan, 4668560
        • Toyohashi Municipal Hospital /ID# 200176 | Toyohashi-shi, Aichi, Japan, 441-8570
        • National Hospital Organization Hirosaki General Medical Center /ID# 165976 | Hirosaki-shi, Aomori, Japan, 036-8545
        • Toho University Sakura Medical Center /ID# 165978 | Sakura-shi, Chiba, Japan, 285-8741
        • Fukuoka University Chikushi Hospital /ID# 214402 | Chikushino-shi, Fukuoka, Japan, 818-8502
        • Kurume University Hospital /ID# 165996 | Kurume-shi, Fukuoka, Japan, 830-0011
        • National Hospital Organization Takasaki General Medical Center /ID# 167151 | Takasaki-shi, Gunma, Japan, 370-0829
        • NHO Fukuyama Medical Center /ID# 167155 | Fukuyama-shi, Hiroshima, Japan, 720-8520
        • Hiroshima University Hospital /ID# 165998 | Hiroshima-shi, Hiroshima, Japan, 734-8551
        • Asahikawa Medical University Hospital /ID# 167148 | Asahikawa-shi, Hokkaido, Japan, 078-8510
        • Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165975 | Sapporo-shi, Hokkaido, Japan, 060-0033
        • Sapporo Medical University Hospital /ID# 167152 | Sapporo-shi, Hokkaido, Japan, 060-8543
        • Sapporo IBD Clinic /ID# 223559 | Sapporo-shi, Hokkaido, Japan, 064-0919
        • Aoyama Clinic /ID# 165993 | Kobe-shi, Hyogo, Japan, 650-0015
        • Hyogo Medical University Hospital /ID# 165991 | Nishinomiya-shi, Hyogo, Japan, 663-8501
        • Kanazawa University Hospital /ID# 169212 | Kanazawa-shi, Ishikawa, Japan, 920-8641
        • Iwate Medical University Uchimaru Medical Center /ID# 202465 | Morioka-shi, Iwate, Japan, 020-8505
        • Imamura General Hospital /ID# 227135 | Kagoshima-shi, Kagoshima, Japan, 890-0064
        • Idzuro Imamura Hospital /ID# 206655 | Kagoshima-shi, Kagoshima, Japan, 892-0824
        • Sameshima Hospital /ID# 206677 | Kagoshima-shi, Kagoshima, Japan, 892-0846
        • Yokohama City University Medical Center /ID# 167156 | Yokohama shi, Kanagawa, Japan, 232-0024
        • Japanese Red Cross Kyoto Daiichi Hosital /ID# 165990 | Kyoto-shi, Kyoto, Japan, 605-0981
        • Kyoto University Hospital /ID# 169887 | Kyoto-shi, Kyoto, Japan, 606-8507
        • Yokkaichi Hazu Medical Center /ID# 167201 | Yokkaichi-shi, Mie, Japan, 510-0016
        • Tohoku University Hospital /ID# 167150 | Sendai-shi, Miyagi, Japan, 9808574
        • Nara Medical University Hospital /ID# 169213 | Kashihara-shi, Nara, Japan, 634-8522
        • Kenseikai Dongo Hospital /ID# 208105 | Yamatotakada-shi, Nara, Japan, 635-0022
        • Niigata University Medical & Dental Hospital /ID# 170042 | Niigata-shi, Niigata, Japan, 951-8520
        • Ishida Clinic of IBD and Gastroenterology /ID# 167149 | Oita-shi, Oita, Japan, 870-0823
        • Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 165994 | Kurashiki-shi, Okayama, Japan, 710-0142
        • Duplicate_Okayama University Hospital /ID# 167354 | Okayama-shi, Okayama, Japan, 700-8558
        • Kinshukai Infusion Clinic /ID# 218873 | Osaka-shi, Osaka, Japan, 530-0011
        • Osaka Metropolitan University Hospital /ID# 165999 | Osaka-shi, Osaka, Japan, 545-8586
        • Osaka University Hospital /ID# 169661 | Suita-shi, Osaka, Japan, 565-0871
        • Osaka Medical and Pharmaceutical University Hospital /ID# 206323 | Takatsuki-shi, Osaka, Japan, 569-8686
        • Tokitokai Tokito clinic /ID# 165977 | Saitama-shi, Saitama, Japan, 336-0963
        • Shiga University of Medical Science Hospital /ID# 167157 | Otsu-shi, Shiga, Japan, 520-2192
        • Hamamatsu University Hospital /ID# 224402 | Hamamatsu-shi, Shizuoka, Japan, 431-3192
        • NHO Shizuoka Medical Center /ID# 167153 | Sunto-gun, Shizuoka, Japan, 411-8611
        • Tokyo Medical And Dental University Hospital /ID# 165982 | Bunkyo-ku, Tokyo, Japan, 113-8519
        • Tokai University Hachioji Hospital /ID# 165984 | Hachioji-shi, Tokyo, Japan, 192-0032
        • The Jikei University Hospital /ID# 167154 | Minato-ku, Tokyo, Japan, 105-8471
        • Tokyo Women's Medical University Hospital /ID# 205979 | Shinjuku-ku, Tokyo, Japan, 162-8666
        • Toyama Prefectural Central Hospital /ID# 217836 | Toyama-shi, Toyama, Japan, 930-8550
        • Japanese Red Cross Wakayama Medical Center /ID# 200641 | Wakayama-shi, Wakayama, Japan, 640-8558
        • Wakayama Medical University Hospital /ID# 169480 | Wakayama-shi, Wakayama, Japan, 641-8510
        • Yamagata University Hospital /ID# 200158 | Yamagata-shi, Yamagata, Japan, 990-9585
        • Kyorin University - Mitaka Campus /ID# 165983 | Mitaka, Japan, 181-8611
        • Kyungpook National University Hospital /ID# 207020 | 중구, Daegu Gwang Yeogsi, Korea, Republic of, 41944
        • Chungang University Hospital /ID# 207021 | Dongjak-gu, Gyeonggido, Korea, Republic of, 06973
        • Duplicate_Hanyang University Gurihospital /ID# 167563 | Guri, Gyeonggido, Korea, Republic of, 11923
        • Duplicate_CHA University Bundang Medical Center /ID# 167569 | Seongnam si, Gyeonggido, Korea, Republic of, 13496
        • Dong-A University Medical Center /ID# 167568 | Busan, Gyeongsangnamdo, Korea, Republic of, 49201
        • Kangbuk Samsung Hospital /ID# 167562 | Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03181
        • Yonsei University Health System Severance Hospital /ID# 167567 | Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03722
        • Inje University Haeundae Hospital /ID# 202631 | Busan, Korea, Republic of, 48108
        • Pusan National University Hospital /ID# 167565 | Busan, Korea, Republic of, 49241
        • Samsung Medical Center /ID# 167564 | Seoul, Korea, Republic of, 06351
        • Pauls Stradins Clinical University Hospital /ID# 169494 | Rīga, Riga, Latvia, 1002
        • VCA Polyclinic Aura /ID# 169499 | Riga, Latvia, 1035
        • Duplicate_Digestive Disease Center Gastro /ID# 169518 | Riga, Latvia, LV-1079
        • Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 207030 | Kaunas, Lithuania, 50161
        • Vilnius University Hospital Santaros Klinikos /ID# 203269 | Vilnius, Lithuania, 08661
        • Hospital Sultanah Bahiyah /ID# 201317 | Alor Setar, Kedah, Malaysia, 05460
        • Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170780 | Kuala Lumpur, Selangor, Malaysia, 56000
        • Universiti Sains Malaysia /ID# 200101 | Kelantan, Malaysia, 16150
        • Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207681 | Victoria de Durango, Durango, Mexico, 34000
        • Morales Vargas Centro de Investigacion S.C. /ID# 203496 | Leon, Guanajuato, Mexico, 37000
        • Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 206843 | Guadalajara, Jalisco, Mexico, 44650
        • Radboud Universitair Medisch Centrum /ID# 166931 | Nijmegen, Gelderland, Netherlands, 6525 GA
        • Zuyderland Medisch Centrum /ID# 169699 | Heerlen, Limburg, Netherlands, 6419 PC
        • Amsterdam UMC, locatie VUmc /ID# 166930 | Amsterdam, Netherlands, 1081 HV
        • Onze Lieve Vrouwe Gasthuis /ID# 166932 | Amsterdam, Netherlands, 1091 AC
        • Medisch Spectrum Twente /ID# 170299 | Enschede, Netherlands, 7512 KZ
        • Vistamed /ID# 208571 | Wroclaw, Dolnoslaskie, Poland, 53-149
        • Malopolskie Centrum Kliniczne /ID# 202169 | Krakow, Malopolskie, Poland, 30-149
        • Duplicate_WIP Warsaw IBD Point Profesor Kierkus /ID# 224302 | Warsaw, Mazowieckie, Poland, 00-728
        • Centrum Zdrowia MDM /ID# 200493 | Warszawa, Mazowieckie, Poland, 00-189
        • Centrum Medyczne Reuma Park /ID# 200489 | Warszawa, Mazowieckie, Poland, 02-665
        • Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170204 | Guimaraes, Braga, Portugal, 4835-044
        • Hospital Egas Moniz /ID# 170232 | Lisbon, Porto, Portugal, 1349-019
        • Duplicate_Hospital Garcia de Orta, EPE /ID# 170209 | Almada, Setubal, Portugal, 2805-267
        • Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200608 | Ponte de Lima, Viana Do Castelo, Portugal, 4990-041
        • Centro Hospitalar Universitario de Sao Joao, EPE /ID# 170211 | Porto, Portugal, 4200-319
        • Mindful Medical Research /ID# 203356 | San Juan, Puerto Rico, 00918-3756
        • School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166769 | San Juan, Puerto Rico, 00935
        • Fundeni Clinical Institute /ID# 167831 | Bucharest, Bucuresti, Romania, 022328
        • Duplicate_Clinica GASTRO MED SRL /ID# 206363 | Cluj-Napoca, Cluj, Romania, 400380
        • Cabinet Particular Policlinic Algomed /ID# 167832 | Timișoara, Romania, 300002
        • Immanuel Kant Baltic Federal University /ID# 203810 | Kaliningrad, Kaliningradskaya Oblast, Russian Federation, 236016
        • LLC Medical Center /ID# 209234 | Novosibirsk, Novosibirskaya Oblast, Russian Federation, 630099
        • Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202989 | Perm, Permskiy Kray, Russian Federation, 614109
        • LLC Novaya Klinika /ID# 206613 | Pyatigorsk, Stavropol Skiy Kray, Russian Federation, 357500
        • Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202996 | Stavropol, Stavropol Skiy Kray, Russian Federation, 355012
        • Kazan State Medical University /ID# 169589 | Kazan, Tatarstan, Respublika, Russian Federation, 420012
        • Olla-Med Clinic /ID# 208723 | Moscow, Russian Federation, 105554
        • P.A. Bayandin Murmansk Regiona /ID# 169590 | Murmansk, Russian Federation, 183047
        • Republican hospital named after V.A. Baranov /ID# 206497 | Petrozavodsk, Russian Federation, 185019
        • Euromedservice /ID# 206608 | Pushkin, Russian Federation, 196603
        • X7 Clinical Research Center /ID# 216348 | Saint Petersburg, Russian Federation, 194156
        • City Clinical Hospital No. 31 /ID# 208871 | St. Petersburg, Russian Federation, 197110
        • Clinical Hosp Center Zvezdara /ID# 168216 | Belgrade, Beograd, Serbia, 11000
        • Military Medical Academy /ID# 168785 | Belgrade, Beograd, Serbia, 11000
        • University Clinical Center Serbia /ID# 168217 | Belgrade, Beograd, Serbia, 11000
        • Clin Hosp Ctr Bezanijska Kosa /ID# 168787 | Belgrade, Beograd, Serbia, 11080
        • Duplicate_University Clinical Center Kragujevac /ID# 205856 | Kragujevac, Sumadijski Okrug, Serbia, 34000
        • Duplicate_Clinical Center Vojvodina /ID# 168196 | Novi Sad, Vojvodina, Serbia, 21000
        • KL Ling Gastroenterology and Liver Clinic /ID# 205739 | Singapore, Singapore, 228510
        • Gleneagles Medical Centre /ID# 206019 | Singapore, Singapore, 258499
        • Tan Tock Seng Hospital /ID# 203158 | Singapore, Singapore, 308433
        • KM Management, spol. s.r.o. /ID# 170202 | Nitra, Nitriansky Kraj, Slovakia, 949 01
        • Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169960 | Banska Bystrica, Slovakia, 975 17
        • Univ Medical Ctr Ljubljana /ID# 211041 | Ljubljana, Slovenia, 1000
        • Farmovs (Pty) Ltd /Id# 207534 | Bloemfontein, Free State, South Africa, 9301
        • Lenasia Clinical Trial Centre /ID# 205143 | Johannesburg, Gauteng, South Africa, 1820
        • Wits Clinical Research /ID# 170850 | Johannesburg, Gauteng, South Africa, 1864
        • Allergy & Immunology (AIU) /ID# 171427 | Cape Town, Western Cape, South Africa, 7700
        • Dr JP Wright /ID# 170882 | Cape Town, Western Cape, South Africa, 7708
        • Private Practice Dr MN Rajabally /ID# 169851 | Cape Town, Western Cape, South Africa, 7800
        • Hospital Universitario Marques de Valdecilla /ID# 202495 | Santander, Cantabria, Spain, 39008
        • Hospital Universitari Son Espases /ID# 201969 | Palma de Mallorca, Illes Balears, Spain, 07120
        • Hospital Universitario Dr. Negrin /ID# 202723 | Las Palmas de Gran Canaria, Las Palmas, Spain, 35019
        • Hospital Universitario de Navarra /ID# 202354 | Pamplona, Navarra, Spain, 31008
        • Duplicate_Hospital Universitario A Coruna - CHUAC /ID# 203909 | A Coruna, Spain, 15006
        • Hospital Universitario Vall d'Hebron /ID# 202721 | Barcelona, Spain, 08035
        • Hospital Clinic de Barcelona /ID# 202726 | Barcelona, Spain, 08036
        • Hospital Universitario de Girona Doctor Josep Trueta /ID# 202644 | Girona, Spain, 17007
        • Hospital Juan Ramon Jimenez /ID# 202727 | Huelva, Spain, 21005
        • Hospital Universitario La Paz /ID# 202725 | Madrid, Spain, 28046
        • Hospital Universitario de Salamanca /ID# 206359 | Salamanca, Spain, 37711
        • Hospital Universitario Virgen Macarena /ID# 202722 | Sevilla, Spain, 41009
        • Hospital Clinico Universitario de Valencia /ID# 209658 | Valencia, Spain, 46010
        • Hospital Universitario y Politecnico La Fe /ID# 202720 | Valencia, Spain, 46026
        • Hallands Hospital Halmstad /ID# 170815 | Halmstad, Hallands Lan, Sweden, 302 33
        • Karolinska University Hospital Solna /ID# 224489 | Solna, Stockholms Lan, Sweden, 171 64
        • Alingsas lasarett /ID# 170814 | Alingsas, Vastra Gotalands Lan, Sweden, 441 33
        • Sodra Alvsborgs sjukhus /ID# 203078 | Boras, Vastra Gotalands Lan, Sweden, 501 82
        • Duplicate_Sahlgrenska University Hospital /ID# 169032 | Gothenburg, Vastra Gotalands Lan, Sweden, 413 46
        • Duplicate_Sahlgrenska University Hospital /ID# 169170 | Gothenburg, Vastra Gotalands Lan, Sweden, 413 46
        • Duplicate_Universitatsspital Zurich /ID# 171000 | Zurich, Zuerich, Switzerland, 8091
        • Inselspital, Universitaetsspital Bern /ID# 170994 | Bern, Switzerland, 3010
        • National Taiwan University Hospital /ID# 169805 | Taipei City, Taipei, Taiwan, 100
        • China Medical University Hospital /ID# 169803 | Taichung, Taiwan, 40447
        • Taichung Veterans General Hospital /ID# 169802 | Taichung, Taiwan, 40705
        • Linkou Chang Gung Memorial Hospital /ID# 169804 | Taoyuan City, Taiwan, 333
        • Gazi Universitesi Tip Fakultes /ID# 217445 | Yenimahalle, Ankara, Turkey, 06560
        • Acibadem Kozyatagi Hospital /ID# 209404 | Kadikoy, Istanbul, Turkey, 34742
        • Sisli Etfal Train & Res Hosp /ID# 171327 | Sisli, Istanbul, Turkey, 34371
        • Duplicate_Erciyes University Medical Fac /ID# 171325 | Melikgazi, Kayseri, Turkey, 38030
        • Ankara Univ Medical Faculty /ID# 206408 | Ankara, Turkey, 06590
        • Inonu Universitesi Turgut Ozal /ID# 201266 | Battalgazi/malatya, Turkey, 44280
        • Mustafa Kemal University Medic /ID# 171328 | Hatay, Turkey, 31001
        • Duplicate_Istanbul University Istanbul Medical Faculty /ID# 171365 | Istanbul, Turkey, 34093
        • Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171326 | Istanbul, Turkey, 34899
        • Mersin University Medical /ID# 171330 | Mersin, Turkey, 33343
        • CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 222111 | Vinnytsia, Vinnytska Oblast, Ukraine, 21018
        • Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 167918 | Kharkiv, Ukraine, 61037
        • Kyiv City Clinical Hospital No.18 /ID# 207890 | Kyiv, Ukraine, 01030
        • Medical Centre of "Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV" /ID# 203739 | Kyiv, Ukraine, 01030
        • MNE KRC Kyiv Regional Clinical Hospital /ID# 202456 | Kyiv, Ukraine, 04106
        • Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 167917 | Lviv, Ukraine, 79000
        • Warrington and Halton Hospitals NHS Foundation Trust /ID# 171396 | Warrington, Cheshire West And Chester, United Kingdom, WA5 1QG
        • Barts Health NHS Trust /ID# 218830 | London, London, City Of, United Kingdom, E1 2ES
        • Mersey and West Lancashire NHS teaching hospitals trust /ID# 209087 | Prescot, Warrington, United Kingdom, L35 5DR
        • Royal United Hospitals Bath /ID# 169062 | Bath, United Kingdom, BA1 3NG
        • Ulster Hospital - South Eastern Health & Social Care Trust /ID# 205324 | Belfast, United Kingdom, BT16 1RH
        • University Hospitals Birmingham NHS Foundation Trust /ID# 169058 | Birmingham, United Kingdom, B15 2TH
        • The Dudley Group NHS Foundation Trust /ID# 169057 | Dudley, United Kingdom, DY1 2HQ
        • London North West University Healthcare NHS Trust /ID# 169056 | Harrow, United Kingdom, HA1 3UJ
        • King's College Hospital NHS Foundation Trust /ID# 169060 | London, United Kingdom, SE5 9RS
        • The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169063 | Newcastle upon Tyne, United Kingdom, NE3 3HD
        • Stockport NHS foundation trust /ID# 208717 | Stockport, United Kingdom, SK2 7JE
        • Taunton and Somerset NHS Foundation Trust /ID# 209666 | Taunton, United Kingdom, TA1 5DA
        • St George's University Hospitals NHS Foundation Trust /ID# 205550 | Tooting, United Kingdom, SW17 0QT
        • The Royal Wolverhampton NHS Trust /ID# 171395 | Wolverhampton, United Kingdom, WV10 0QP
        Investigators

          More Information

          Additional Information

          Additional Relevant MeSH Terms

          • Crohn Disease
          • Inflammatory Bowel Diseases
          • Gastroenteritis
          • Gastrointestinal Diseases
          • Digestive System Diseases
          • Intestinal Diseases