ATHENA (A Multicenter, Randomized, Double-Blind, Placebo- Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy)

ClinicalTrials.gov processed this data on July 10, 2024. Link to the current ClinicalTrials.gov record.

Recruitment Status

ACTIVE, NOT RECRUITING (See Contacts and Locations)
Verified July 2024 by pharmaand GmbH, Bristol-Myers Squibb, Gynecologic Oncology Group, European Network of Gynaecological Oncological Trial Groups (ENGOT), Foundation Medicine

Sponsor

pharmaand GmbH

Information Provided by (Responsible Party)

pharmaand GmbH

Clinicaltrials.gov Identifier

NCT03522246
Other Study ID Numbers: CO-338-087/GOG-3020/ENGOT-ov45
First Submitted: April 9, 2018
First Posted: May 11, 2018
Last Update Posted: July 12, 2024
Last Verified: July 2024
History of Changes

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Study Description

Not Provided
Condition or Disease Intervention/Treatment
  • Epithelial Ovarian Cancer
  • Primary Peritoneal
  • Fallopian Tube Cancer
  • Newly Diagnosed
  • FIGO Stage III-IV
  • Partial Response
  • Complete Response
  • Drug: Rucaparib
  • Drug: Nivolumab
  • Drug: Placebo Oral Tablet
  • Drug: Placebo IV Infusion

Study Design

Study TypeInterventional
Anticipated Enrollment1000 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingQuadruple
Primary PurposeTreatment
Official TitleATHENA (A Multicenter, Randomized, Double-Blind, Placebo- Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy)
Study Start DateMay 14, 2018
Actual Primary Completion DateMay 20, 2024
Anticipated Study Completion DateDecember 30, 2030

Groups and Cohorts

Group/ CohortIntervention/ Treatment
  • Arm A
    • oral rucaparib + intravenous (IV) nivolumab
  • Drug: Rucaparib
    • Oral rucaparib will be administered twice daily
  • Drug: Nivolumab
    • Arm B
      • oral rucaparib+IV placebo
    • Drug: Rucaparib
      • Oral rucaparib will be administered twice daily
    • Drug: Placebo IV Infusion
      • Arm C
        • oral placebo+ IV nivolumab
      • Drug: Nivolumab
        • Drug: Placebo Oral Tablet
          • Arm D
            • Oral placebo + IV placebo
          • Drug: Placebo Oral Tablet
            • Drug: Placebo IV Infusion

              Outcome Measures

              Primary Outcome Measures

              1. Investigator assessed Progression-free survival (PFS) [From randomization until disease progression (up to approximately 7 years)]

              Secondary Outcome Measures

              1. Blinded independent central review (BICR) PFS [Every ~12 weeks after the start of combination treatment for ~3 years, then every ~24 weeks thereafter until disease progression. Study data collection expected to last for ~7 years]
              2. Overall Survival (OS) [From enrollment to primary study completion of study (up to approximately 10 years)]
              3. Objective response rate (ORR) [For patients with measurable disease, every ~12 weeks after the start of combination treatment for ~3 years, then every ~24 weeks thereafter until disease progression. Study data collection expected to last for ~7 years]
              4. Duration of response (DOR) [For patients with measurable disease, every ~12 weeks after the start of combination treatment for ~3 years, then every ~24 weeks thereafter until disease progression. Study data collection expected to last for ~7 years]
              5. Number of participants with treatment-emergent Adverse Events (AEs) as assessed by CTCAE v4 (or higher) as a measure of safety and tolerability [Collected from the time patient receives first dose of study drug until post treatment safety follow-up period (up to approximately 10 years)]
              6. Number of participants with serious AEs as a measure of safety and tolerability [Collected from the time patient receives first dose of study drug until post treatment safety follow-up period (up to approximately 10 years)]
              7. Number of participants with laboratory abnormalities as a measure of safety and tolerability [Collected from the time patient receives first dose of study drug until post treatment safety follow-up period (up to approximately 10 years)]

              Eligibility Criteria

              Ages Eligible for Study 18 Years and Older (Adult, Older Adult)
              Sexes Eligible for Study Female
              Accepts Healthy Volunteers No
              Inclusion Criteria
              • Newly diagnosed advanced (FIGO stage III-IV) epithelial ovarian, fallopian tube, or primary peritoneal cancer.
              • Completed cytoreductive surgery, including at least a bilateral salpingo-oophorectomy and partial omentectomy, either prior to chemotherapy (primary surgery) or following neoadjuvant chemotherapy (interval debulking)
              • Completed first-line platinum-based chemotherapy and surgery with a response, in the opinion of the Investigator
              • Sufficient tumor tissue for planned analysis
              • ECOG performance status of 0 or 1
              • Patients must be 20 years of age to consent in Japan, Taiwan and South Korea; in all other participating countries patients must be 18 years of age to consent
              Exclusion Criteria
              • Pure sarcomas or borderline tumors or mucinous tumors
              • Active second malignancy
              • Known central nervous system brain metastases
              • Any prior treatment for ovarian cancer, other than the first-line platinum regimen
              • Evidence of interstitial lung disease or active pneumonitis
              • Active, known or suspected autoimmune disease
              • Condition requiring active systemic treatment with either corticosteroids (>10 mg daily prednisone equivalent) or other immunosuppressive medications

              Contacts and Locations

              Sponsors and Collaborators pharmaand GmbH, Bristol-Myers Squibb, Gynecologic Oncology Group, European Network of Gynaecological Oncological Trial Groups (ENGOT), Foundation Medicine
              Bristol-Myers Squibb, Gynecologic Oncology Group, European Network of Gynaecological Oncological Trial Groups (ENGOT), Foundation Medicine
              Locations
              • Arizona Oncology Associates, PC - HAL | Phoenix, Arizona, United States, 85016
              • Arizona Oncology Associates, PC - HOPE | Tucson, Arizona, United States, 85711
              • The University of Arizona Cancer Center | Tucson, Arizona, United States, 85724
              • John Muir Clinical Research Center | Concord, California, United States, 94520
              • UCLA Women's Health Clinical Research Unit | Los Angeles, California, United States, 90095
              • Kaiser Permanente Northern California | San Francisco, California, United States, 94589
              • University of Colorado Cancer Center | Aurora, Colorado, United States, 80045
              • Rocky Mountain Cancer Centers | Lakewood, Colorado, United States, 80228
              • Yale University | New Haven, Connecticut, United States, 06520
              • Florida Gynecologic Oncology | Fort Myers, Florida, United States, 33905
              • MD Anderson Cancer Center-Baptist | Jacksonville, Florida, United States, 32207
              • Baptist Health Medical Group Oncology, LLC | Miami, Florida, United States, 33176
              • Florida Hospital | Orlando, Florida, United States, 32804
              • Northside Hospital | Atlanta, Georgia, United States, 30342
              • Augusta University | Augusta, Georgia, United States, 30912
              • Rush University Medical Center | Chicago, Illinois, United States, 60612
              • Dr. Sudarshan K. Sharma, Ltd - Gynecologic Oncology | Hinsdale, Illinois, United States, 60521
              • Van le | Springfield, Illinois, United States, 62769
              • Community Health Network | Indianapolis, Indiana, United States, 46250
              • University of Iowa Hospitals | Iowa City, Iowa, United States, 52242
              • University of Kansas Cancer Center | Westwood, Kansas, United States, 66205
              • University of Kentucky | Lexington, Kentucky, United States, 40536
              • Norton Cancer Institute | Louisville, Kentucky, United States, 40241
              • Ochsner Medical Center | New Orleans, Louisiana, United States, 70121
              • Maine Medical Center | Scarborough, Maine, United States, 04074
              • SKCCC at Johns Hopkins | Baltimore, Maryland, United States, 21287
              • Massachusetts General Hospital | Boston, Massachusetts, United States, 02114
              • Karmanos Cancer Institute | Detroit, Michigan, United States, 48201
              • Metro Minnesota Community Oncology Research Consortium | Saint Louis Park, Minnesota, United States, 55416
              • Washington University School of Medicine | Saint Louis, Missouri, United States, 63110
              • Women's Cancer Center of Nevada | Las Vegas, Nevada, United States, 89169
              • MD Anderson Cancer Center at Cooper | Camden, New Jersey, United States, 08103
              • Summit Medical Group | Florham Park, New Jersey, United States, 07932
              • Women's Cancer Care Associates | Albany, New York, United States, 12008
              • Broome Oncology, LLC | Johnson City, New York, United States, 13790
              • Northwell Health Monter Cancer Center | Lake Success, New York, United States, 11042
              • New York University Medical Center | New York, New York, United States, 10016
              • University of North Carolina | Chapel Hill, North Carolina, United States, 27707
              • University of Cincinnati | Cincinnati, Ohio, United States, 45221
              • Oncology Hematology Care, Inc | Cincinnati, Ohio, United States, 45242
              • Cleveland Clinic | Cleveland, Ohio, United States, 44106
              • The Ohio State University | Columbus, Ohio, United States, 43210
              • MD Anderson Cancer Center - Ohio Health | Columbus, Ohio, United States, 44907
              • University of Oklahoma Health Science Center | Oklahoma City, Oklahoma, United States, 73104
              • Oklahoma Cancer Specialists and Research Institute | Tulsa, Oklahoma, United States, 74146
              • Oncology Associates of Oregon, P.C. | Eugene, Oregon, United States, 97401
              • LMG Gynecologic Oncology | Portland, Oregon, United States, 97210
              • Northwest Cancer Specialists, P.C. | Portland, Oregon, United States, 97225
              • University of Pennsylvania | Philadelphia, Pennsylvania, United States, 19104
              • Thomas Jefferson University | Philadelphia, Pennsylvania, United States, 19107
              • UPMC Magee-Womens Hospital | Pittsburgh, Pennsylvania, United States, 15213
              • Abington Memorial Hospital | Willow Grove, Pennsylvania, United States, 19090
              • Avera Gynecologic Oncology | Sioux Falls, South Dakota, United States, 57105
              • Texas Oncology - Austin Central | Austin, Texas, United States, 78731
              • Texas Oncology - Bedford | Bedford, Texas, United States, 76022
              • Texas Oncology - Dallas Presbyterian Hospital | Dallas, Texas, United States, 75231
              • Texas Oncology - Fort Worth | Fort Worth, Texas, United States, 76104
              • Memorial Hermann | Houston, Texas, United States, 77030
              • University of Texas MD Anderson Cancer Center | Houston, Texas, United States, 77030
              • Texas Oncology - San Antonio Medical Center | San Antonio, Texas, United States, 78240
              • Texas Oncology - The Woodlands, Gynecologic Oncology | The Woodlands, Texas, United States, 77380
              • Huntsman Cancer Institute | Salt Lake City, Utah, United States, 84112
              • Virginia Oncology Associates | Norfolk, Virginia, United States, 23502
              • Froedtert and Medical College of Wisconsin | Milwaukee, Wisconsin, United States, 53226
              • Newcastle Private Hospital | New Lambton Heights, New South Wales, Australia, 2145
              • Northern Cancer Institute St Leonards | Saint Leonards, New South Wales, Australia, 2065
              • Prince of Wales Hospital | Sydney, New South Wales, Australia, 2031
              • Westmead Hospital | Westmead, New South Wales, Australia, 2145
              • Royal Brisbane and Women's Hospital | Brisbane, Queensland, Australia, 4020
              • Brian Fricker Oncology Centre, Burnside Hospital | Toorak Gardens, South Australia, Australia, 5065
              • Peter MacCallum Cancer Center | Melbourne, Victoria, Australia, 3000
              • St John of God Subiaco Hospital | Subiaco, Western Australia, Australia, 6005
              • UZ Leven | Leuven, Belgium, 3000
              • Alberta Health Services - University of Calgary | Calgary, Alberta, Canada, T2N 1N4
              • Alberta Health Services and The University of Alberta | Edmonton, Alberta, Canada, T6G 2B7
              • BC Cancer - Abbotsford | Abbotsford, British Columbia, Canada, V2S 0C2
              • BC Cancer - Kelowna | Kelowna, British Columbia, Canada, V1Y 5L3
              • BC Cancer - Surrey | Surrey, British Columbia, Canada, V3V 1Z2
              • CancerCare Manitoba | Winnipeg, Manitoba, Canada, R3E 0V9
              • Nsha-Qeii Hsc | Halifax, Nova Scotia, Canada, B3H 2Y9
              • Juravinski Cancer Center | Hamilton, Ontario, Canada, LbV 5C2
              • London Health Sciences Center | London, Ontario, Canada, N6A 5W9
              • Ottawa Hospital Cancer Centre | Ottawa, Ontario, Canada, K1H 8L6
              • Centre Hospitalier de l'Université de Montreal | Montréal, Quebec, Canada, H2X 0C2
              • McGill University Health Center | Montréal, Quebec, Canada, H4A 3J1
              • Centre Integre Universitaire de sante et de service sociaux de l'Estri-Centre hospitalier univeritaire de Sherbrooke | Sherbrooke, Quebec, Canada, J1H 5N4
              • Masaryk Memorial Cancer Institute | Brno, Czechia, 65653
              • Department of Gynecology and Obstetrics, Oncogynecological center U hiversity Hospital Kralovske Vinohrady | Prague, Czechia,
              • KOC KNTB a.s. Zlfn, Hvalfckovo nabrezf 600, 76001 | Zlín, Czechia,
              • Aalborg University Hospital | Aalborg, Denmark, 9000
              • Odense University Hospital | Odense, Denmark, 5000
              • Kuopio University Hospital | Kuopio, Finland, 70210
              • Klinik für Frauenheilkunde und Geburtshilfe | Dessau, Germany,
              • Universitaetsklinikum Duesseldorf / Klinik fur Frauenheilkunde & Geburtshilfe | Duesseldorf, Germany,
              • Universitatsklinikum National Centrum for Tumor Disease (NCT) | Heidelberg, Germany,
              • Universitätslinikum Mannheim, Frauenklinik | Mannheim, Germany,
              • Kliniken Suedostbayern AG, Klinikum Traunstein | Traunstein, Germany,
              • Attikon General University Hospital | Chaidari, Athens, Greece, 12462
              • University Hospital Attikon | Chaidari, Athens, Greece, 12462
              • Alexandra Hospital | Athens, Greece, 11528
              • General Hospital of Patras | Patra, Greece, 26335
              • Euromedica General Clinic, B' Oncology Clinic | Thessaloniki, Greece, 5465
              • Cork University Hospital | Cork, Ireland, T12 DC4A
              • Bon Secours Hospital | Cork, Ireland,
              • University Hospital Limerick | Limerick, Ireland, V94 F858
              • University Hospital Waterford | Waterford, Ireland, X91 ER8E
              • Shaare Zedek Medical Oncology | Jerusalem, Israel,
              • Meir Medical Center | Kfar Saba, Israel, 4428164
              • Galilee Medical Center | Nahariya, Israel, 2210001
              • Sheba Medical Center | Ramat Gan, Israel, 5265601
              • Ziv Medical Center | Safed, Israel, 13100
              • Tel Aviv Sourasky Medical Center | Tel Aviv, Israel, 6423906
              • Centro di Riferimento Oncologico, CRO-IRCCS | Aviano, Italy, 33081
              • Candiolo Cancer Institute - IRCCS | Candiolo, Italy, 10060
              • Arnas Garibaldi | Catania, Italy, 95122
              • University G, D'Annunuzio-Chieti | Chieti, Italy,
              • IRCCS Instituto Nazionale Tumori | Napoli, Italy, 80131
              • Azienda Ospedaliera Universitaria Policlinico Umberto I | Roma, Italy, 00161
              • Policlinico Agostino Gemelli | Roma, Italy, 00168
              • Ospedale S. Giovanni Calibita Fatebenefratelli | Roma, Italy, 00186
              • Ospedale San Bortolo | Vicenza, Italy, 36100
              • University of Tsukuba Hospital | Tsukuba, Amakubo, Japan,
              • National Cancer Center Hospital East | Kashiwa, Chiba, Japan, 277-8577
              • Kurume University Hospital | Kurume, Fukuoka, Japan, 830-0011
              • Yokohama City University Hospital | Yokohama, Fukuura, Japan,
              • Gunma University Hospital | Maebashi, Gunma, Japan, 371-8511
              • Gunma Prefectural Cancer Center | Ota-shi, Gunma, Japan, 373-8550
              • Hiroshima City Hiroshima Citizens Hospital | Naka, Hiroshima, Japan, 730-0844,
              • Hyogo Cancer Center | Akashi, Hyogo, Japan, 673-0021
              • Iwate Medical University | Morioka, Iwate, Japan,
              • Nippon Medical School Musashikosugi Hospital | Kawasaki-shi, Kanagawa, Japan, 211-8533
              • Kanagawa Cancer Center | Yokohama, Kanagawa, Japan, 241-8515
              • National Defense Medical College Hospital | Tokorozawa, Namiki, Japan,
              • Osaka International Cancer Institute | Chuo, Osaka, Japan, 541-8567
              • Kindai University Hospital | Ōsaka-sayama, Osaka, Japan, 589-8511
              • Saitama Medical University International Medical Center | Hidaka, Saitama, Japan, 350-1298
              • Keio University Hospital | Shinjuku-Ku, Shinanomachi, Japan,
              • The Cancer Institute Hospital of JFCR | Koto-Ku, Tokyo, Japan,
              • Saitama Cancer Center | Saitama, Japan, 362-0806
              • Kagawa Prefectural Central Hospital | Takamatsu, Japan,
              • National Cancer Center Hospital | Tokyo, Japan, 104-0045
              • National Cancer Center | Goyang-si, Gyeonggi-do, Korea, Republic of, 10408
              • Seoul National University Bundang Hospital | Seongnam-si, Gyeonggi-do, Korea, Republic of, 13620
              • CHA Bundang Medical Center | Seongnam, Gyeonggi-do, Korea, Republic of, 13496
              • Gachon University Gil Medical Center | Incheon, Seoul, Korea, Republic of, 21565
              • SoonChunHyang Univeristy Cheonan Hosptial | Cheonan, Korea, Republic of,
              • Korea Cancer Center Hospital | Seoul, Korea, Republic of, 01812
              • Seoul National University Hospital | Seoul, Korea, Republic of, 03080
              • Severance Hospital,Yonsei University Health System | Seoul, Korea, Republic of, 03722
              • Konkuk University Medical Center | Seoul, Korea, Republic of, 05030
              • Asan Medical Center | Seoul, Korea, Republic of, 05505
              • Samsung Medical Center | Seoul, Korea, Republic of, 06351
              • Korea University Guro Hospital | Seoul, Korea, Republic of,
              • Ajou University Hospital | Suwon-si, Korea, Republic of,
              • Auckland City Hospital | Auckland, New Zealand, 1023
              • Christchurch Hospital | Christchurch, New Zealand, 8011
              • Waikato Hospital | Hamilton, New Zealand, 3204
              • Palmerston North Hospital | Palmerston North, New Zealand, 4442
              • Tauranga Hospital | Tauranga, New Zealand, 3112
              • Chair & department of Obsterics, Gynaecology and Oncology (previous site) | Warsaw, Kondratowicza, Poland,
              • Bialostockie Centrum Onkologii Oddzial Onkologii Ginekologicznej | Bialystok, Poland, 20-081
              • University Hospital of Bialystok | Białystok, Poland,
              • Szpitale Pomorskie sp zoo | Gdynia, Poland, 81-519
              • Medical University of Lublin | Lublin, Poland, 20-081
              • Wielkopolskie Centrum Onkologii | Poznań, Poland, 61-866
              • Pomeranian Medical University | Szczecin, Poland,
              • Spitalul Clinic Municipal "Dr. Gavril Curteanu" | Oradea, Jud. Bihor, Romania, 410469
              • S.C. Medisprof S.R.L. | Cluj-Napoca, Jud. Cluj, Romania, 400641
              • Oncopremium Team | Baia Mare, Romania,
              • SC Quantum Medical Center SRL | Bucuresti, Romania,
              • Instiute of Oncology - Medical Oncology | Cluj-Napoca, Romania,
              • Centrul de Oncologie Sf.Nectarie | Craiova, Romania, 200347
              • S.C Oncolab S.R.L | Craiova, Romania,
              • Institutul Regional de Oncologie Iasi | Iaşi, Romania, 700489
              • Spital Municipal Ploiesti | Ploieşti, Romania,
              • Spitalul Judetean de Urgenta "Sfantul Ioan cel Nou" Suceava | Suceava, Romania, 720237
              • ONCOMED Timisoara | Timişoara, Romania, 300239
              • Arkhangelsk Clinical Oncological Dispensary | Arkhangel'sk, Russian Federation, 163045
              • BHI of Omsk Region Clinical Oncology Dispensary | Omsk, Russian Federation, 644013
              • Orenburg Regional Clinical Oncological Dispensary | Orenburg, Russian Federation,
              • SBHI Saint Petersburg Research Center specialized types of medical care (Oncology) | Pesochnyy, Russian Federation, 197758
              • SBHI SR Pyatigorsk Interdistrict Oncology Dispensary | Pyatigorsk, Russian Federation, 357502
              • Limited Liability Company MedPomosch | Saint Petersburg, Russian Federation, 194356
              • FSBEI HE I.P. Pavlov SPbSMU MoH Russia | Saint Petersburg, Russian Federation, 197022
              • Saint-Petersburg State Budget Institution of Healthcare City Clinical Oncology Dispensary | Saint Petersburg, Russian Federation, 198255
              • 1st Medical University | Saint Petersburg, Russian Federation,
              • Federa; State Budgetary Educational Institution of Higher Education National Research Ogarev Mordovia State University | Saransk, Russian Federation, 430032
              • State Medical Institution "Oncology Center #2" under the Krasnodar Region Healthcare Department | Sotchi, Russian Federation, 354057
              • National University Hospital | Singapore, Singapore, 119082
              • National Cancer Center Singapore | Singapore, Singapore,
              • Vall d'Hebron Institute of Oncology | Barcelona, Spain, 08035
              • Hospital de la Santa Creu i Sant Pau | Barcelona, Spain, 08041
              • Hospital Universitario Basurto | Bilbao, Spain, 48013
              • Consorcio Hospitalario Provincial Castellon | Castillón, Spain, 12002
              • Hospital Virgen de la Arrixaca | El Palmar, Spain, 30120
              • Hospital de Jerez | Jerez de la Frontera, Spain, 11407
              • Hospital Universitario Puerta de Hierro - Majadahonda | Madrid, Spain, 28222
              • Hospital Universitario Central de Asturias | Oviedo, Spain, 33011
              • Hospital Son Llatzer | Palma De Mallorca, Spain, 07198
              • Hospital Nuestra Señora de Valme | Sevilla, Spain, 41014
              • Onkologiska Kliniken | Linköping, Sweden,
              • Onkologiska Kliniken | Lund, Sweden,
              • Karolinska Universitetssjukhuset | Stockholm, Sweden,
              • Hualien Tzu Chi Hospital | Hualien City, Taiwan,
              • Kaohsiung Veterans General Hospital | Kaohsiung, Taiwan, 81362
              • Far Eastern Memorial Hospital | New Taipei City, Taiwan, 22060
              • Taichung Veterans General Hospital | Taichung, Taiwan, 40705
              • China Medical University Hospital | Taichung, Taiwan,
              • Chi Mei Hospital, Liouying (CMHLY) | Tainan, Taiwan,
              • Chi Mei Medical Center (CMMC) | Tainan, Taiwan,
              • National Taiwan University Hospital | Taipei, Taiwan, 10048
              • Mackay Memorial Hospital | Taipei, Taiwan, 10449
              • Taipei Veterans General Hospital | Taipei, Taiwan, 11217
              • Tri-Service General Hospital | Taipei, Taiwan, 11490
              • Taipei Medical Univeristy Hopsital | Taipei, Taiwan,
              • Chang Gung Medical Foundation- Linkou Branch | Taoyuan, Taiwan, 33305
              • Dr. Abdurrahman Yurtaslan Ankara Women's Health Education and Research Hospital | Ankara, Turkey,
              • Istanbul University-cerrahpasa, Cerrahpasa School of Medicine | Istanbul, Turkey,
              • Koc University School of Medicine, Koc University Hospital | Istanbul, Turkey,
              • Celal Bayar University Faculty of Medicine | Manisa, Turkey, 45030
              • Baskent University Hospital | Yuregir, Turkey,
              • East Kent Hospitals University NHS Foundation trust Medical Oncology | Canterbury, Kent, United Kingdom, CT1 3NG
              • Northampton General Hospital | Cliftonville, Northampton, United Kingdom, NN1 5BD
              • Royal Sussex County Hospital | Brighton, United Kingdom, BN2 3EH
              • Bristol Cancer Institute Medical Oncology | Bristol, United Kingdom, BS2 8HW
              • Addenbrookes Hospital | Cambridge, United Kingdom, CB2 0QQ
              • Western General Hospital | Edinburgh, United Kingdom, EH4 2XU
              • University Hospitals of Morecambe Bay NHS Foundation Trust | Lancaster, United Kingdom, LA1 4RP
              • St. James University Hospital | Leeds, United Kingdom, LS9 7TF
              • Barts and the London NHS Trust | London, United Kingdom, EC1A 7BE
              • University of College London Hospital | London, United Kingdom, NW1 2PG
              • Guy's & St Thomas' NHS Foundation Trust (Guy's Cancer Centre) | London, United Kingdom, SE1 9RT
              • The Royal Marsden NHS Foundation Trust | London, United Kingdom, SW3 6JJ
              • Imperial College London | London, United Kingdom, W12 0HS
              • The James Cook University Hospital | Middlesbrough, United Kingdom, TS4 3BW
              • Poole Hospital NHS Foundation Trust | Poole, United Kingdom, BH15 2JB
              • South West Wales Cancer Centre - Singleton Hospital | Swansea, United Kingdom, SA2 8QA
              • Musgrove Park Hospital | Taunton, United Kingdom, TA1 5DA

              More Information

              Publications

              Additional Relevant MeSH Terms

              • Ovarian Neoplasms
              • Carcinoma, Ovarian Epithelial
              • Fallopian Tube Neoplasms
              • Endocrine Gland Neoplasms
              • Neoplasms by Site
              • Neoplasms
              • Ovarian Diseases
              • Adnexal Diseases
              • Genital Diseases, Female
              • Female Urogenital Diseases
              • Female Urogenital Diseases and Pregnancy Complications
              • Urogenital Diseases
              • Genital Neoplasms, Female
              • Urogenital Neoplasms
              • Genital Diseases
              • Endocrine System Diseases
              • Gonadal Disorders
              • Carcinoma
              • Neoplasms, Glandular and Epithelial
              • Neoplasms by Histologic Type
              • Fallopian Tube Diseases