A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active- Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients With Moderately to Severely Active Crohn's Disease

ClinicalTrials.gov processed this data on December 7, 2023. Link to the current ClinicalTrials.gov record.

Recruitment Status

COMPLETED (See Contacts and Locations)
Verified December 2023 by Eli Lilly and Company

Sponsor

Eli Lilly and Company

Information Provided by (Responsible Party)

Eli Lilly and Company

Clinicaltrials.gov Identifier

NCT03926130
Other Study ID Numbers: 16590
First Submitted: April 23, 2019
First Posted: April 24, 2019
Last Update Posted: December 8, 2023
Last Verified: December 2023
History of Changes

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Study Description

Not Provided
Condition or Disease Intervention/Treatment
  • Crohn's Disease
  • Drug: Mirikizumab
  • Drug: Mirikizumab
  • Drug: Ustekinumab
  • Drug: Ustekinumab
  • Drug: Placebo
  • Drug: Placebo

Study Design

Study TypeInterventional
Actual Enrollment1158 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingTriple
Primary PurposeTreatment
Official TitleA Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active- Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients With Moderately to Severely Active Crohn's Disease
Study Start DateJuly 23, 2019
Actual Primary Completion DateAugust 23, 2023
Actual Study Completion DateOctober 2, 2023

Groups and Cohorts

Group/ CohortIntervention/ Treatment
  • Mirikizumab
    • Mirikizumab given intravenously (IV) and subcutaneously (SC).

      Participants in the open-label adolescent addendum will be given mirikizumab IV and SC.
  • Drug: Mirikizumab
    • Administered IV
  • Ustekinumab
    • Ustekinumab given IV and SC.
  • Drug: Ustekinumab
    • Placebo
      • Placebo given IV and SC.
    • Drug: Placebo

      Outcome Measures

      Primary Outcome Measures

      1. Percentage of Participants Achieving Clinical Response at Week 12 and Endoscopic Response at Week 52 [Baseline to Week 52]
        Clinical response by Patient Reported Outcome (PRO) based on stool frequency (SF) and abdominal pain (AP)

        Endoscopic response based on Simple Endoscopic Score for Crohn's Disease (SES-CD) total score
      2. Percentage of Participants Achieving Clinical Response at Week 12 and Clinical Remission at Week 52 [Baseline to Week 52]
        Clinical response by PRO based on SF and AP

        Clinical remission based on CDAI

      Secondary Outcome Measures

      1. Percentage of Participants Achieving Endoscopic Response [Week 52]
        Endoscopic response based on Simple Endoscopic Score for Crohn's Disease (SES-CD) total score
      2. Percentage of Participants Achieving Clinical Remission [Week 52]
        Clinical remission based on Crohn's Disease Activity Index (CDAI)
      3. Percentage of Participants Achieving Endoscopic Response [Week 12]
        Endoscopic Response based on SES-CD total score
      4. Percentage of Participants Achieving Endoscopic Remission [Week 12]
        Endoscopic remission based on SES-CD total score
      5. Percentage of Participants Achieving Clinical Remission [Week 12]
        Clinical remission based on CDAI
      6. Change from Baseline in Urgency Numeric Rating Score (NRS) [Baseline, Week 12]
        Change from Baseline in Urgency NRS
      7. Change from Baseline in Urgency NRS [Baseline, Week 52]
        Change from Baseline in Urgency NRS
      8. Percentage of Participants Achieving Clinical Response at Week 12 and Clinical Remission by PRO at Week 52 [Baseline to Week 52]
        Clinical Response and Clinical Remission based on PRO
      9. Percentage of Participants Achieving Clinical Response at Week 12 and Endoscopic Remission at Week 52 [Baseline to Week 52]
        Clinical Response by PRO and Endoscopic Remission by SES-CD
      10. Percentage of Participants Achieving Clinical Response at Week 12 and Corticosteroid-free AND either in Clinical Remission or Endoscopic Remission at Week 52 [Baseline to Week 52]
        Clinical Response by PRO, Clinical remission by CDAI, Endoscopic Remission by SES-CD
      11. Change from Baseline in C-Reactive Protein [Baseline, Week 52]
        Change from baseline in C-Reactive Protein
      12. Change from Baseline in Fecal Calprotectin [Baseline, Week 52]
        Change from baseline in fecal calprotectin
      13. Percentage of Participants with Extraintestinal Manifestations (EIMs) of Crohn's Disease [Week 52]
        Percentage of participants with EIMs of Crohn's Disease
      14. Percentage of Participants with Fistulae Response [Week 52]
        Percentage of participants with fistulae response
      15. Pharmacokinetics (PK): Area Under the Concentration Time Curve (AUC) of Mirikizumab [Baseline through Week 52]
        PK: AUC of mirikizumab
      16. Change from Baseline in Health Related Quality of Life [Baseline, Week 52]
        Health related quality of life based on Inflammatory Bowel Disease Questionnaire (IBDQ) score

      Eligibility Criteria

      Ages Eligible for Study 15 Years to 80 Years (Child, Adult, Older Adult)
      Sexes Eligible for Study All
      Accepts Healthy Volunteers No
      Inclusion Criteria
      • Diagnosis of CD for at least 3 months prior to baseline
      • Confirmed diagnosis of moderate to severe CD as assessed by SF, AP score, and SES-CD
      • Demonstrated intolerance, loss of response or inadequate response to conventional or to biologic therapy for CD
      • If female, subject must meet the contraception recommendations
      Exclusion Criteria
      • Have a current diagnosis of ulcerative colitis, inflammatory bowel disease-unclassified (IBD-U) (formerly known as indeterminate colitis) or short bowel syndrome
      • Currently have or are suspected to have an abscess. Recent cutaneous and perianal abscesses are not exclusionary if drained, adequately treated and resolved at least 3 weeks prior to baseline or 8 weeks prior to baseline for intra-abdominal abscesses, provided that there is no anticipated need for any further surgery
      • Have a stoma, ileoanal pouch or ostomy
      • Have had a bowel resection within 6 months, or any kind of intra-abdominal or extra abdominal surgery within 3 months of baseline
      • Have ever received any monoclonal antibodies binding IL-23

      Contacts and Locations

      Sponsors and Collaborators Eli Lilly and Company
      Locations
      • University of Alabama-The Kirklin Clinic | Birmingham, Alabama, United States, 35233
      • Digestive Health Specialists | Dothan, Alabama, United States, 36301
      • Lakeview Clinical Research | Guntersville, Alabama, United States, 35976
      • Care Access Research - Tuscaloosa | Tuscaloosa, Alabama, United States, 35406
      • Research Solutions of Arizona | Litchfield Park, Arizona, United States, 85340
      • Central Arizona Medical Associates, PC | Mesa, Arizona, United States, 85206
      • Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, Arizona, United States, 85037
      • Reliance Research | Scottsdale, Arizona, United States, 85260
      • Synexus Site Network | Tempe, Arizona, United States, 85282
      • inSite Digestive Health Care | Arcadia, California, United States, 91006
      • B G Clinical Research, Inc. | Encinitas, California, United States, 92024
      • Care Access - Gilroy | Gilroy, California, United States, 95020
      • Newport Huntington Med Grp | Huntington Beach, California, United States, 92648
      • Om Research, LLC | Lancaster, California, United States, 93534
      • GastroIntestinal Biosciences Clinical Trials | Los Angeles, California, United States, 90067
      • California Medical Research Associates | Northridge, California, United States, 91324
      • University of California Irvine | Orange, California, United States, 92868
      • inSite Digestive Health Care | Pasadena, California, United States, 91105
      • Care Access Research - San Jose | San Jose, California, United States, 95124
      • Wolverine Clinical Trials, LLC | Santa Ana, California, United States, 92705
      • Fomat Medical Research, Inc. | Thousand Oaks, California, United States, 91360
      • Connecticut Gastroenterology | Manchester, Connecticut, United States, 06040
      • IMR of South Florida | Aventura, Florida, United States, 33180
      • Gastroenterology Consultants of Clearwater | Clearwater, Florida, United States, 33756
      • West Central Gastroenterology d/b/a Gastro Florida | Clearwater, Florida, United States, 33761
      • Inpatient Research Clinic | Hialeah, Florida, United States, 33013
      • Doral Medical Research | Hialeah, Florida, United States, 33016
      • C2 Research Center, LLC | Jacksonville, Florida, United States, 32204
      • I.H.S. Health, LLC | Kissimmee, Florida, United States, 34741
      • Central Florida Gastro Research | Kissimmee, Florida, United States, 34744
      • Florida Research Institute | Lakewood Ranch, Florida, United States, 34211
      • Wellness Clinical Research | Lehigh Acres, Florida, United States, 33936
      • Goji Group - Research Trials Group | Miami Lakes, Florida, United States, 33016
      • Wellness Clinical Research | Miami Lakes, Florida, United States, 33016
      • Columbus Clinical Services, LLC | Miami, Florida, United States, 33125
      • Infinite Clinical Research | Miami, Florida, United States, 33133
      • Nickalus Children's Hospital Research Institute | Miami, Florida, United States, 33155
      • Research Associates of South Florida, LLC | Miami, Florida, United States, 33156
      • SaludMax Medical Corp | Miami, Florida, United States, 33165
      • Ezy Medical Research | Miami, Florida, United States, 33175
      • Coral Research Clinic Corp | Miami, Florida, United States, 33186
      • Center for Interventional Endoscopy | Orlando, Florida, United States, 32803
      • Endoscopic Research Inc | Orlando, Florida, United States, 32803
      • Orlando Health, Inc | Orlando, Florida, United States, 32806
      • Clintheory Healthcare | Orlando, Florida, United States, 32819
      • Care Access Research - Orlando | Orlando, Florida, United States, 32825
      • Digestive and Liver Center of Florida | Orlando, Florida, United States, 32825
      • Gastroenterology Associates of Pensacola, PA | Pensacola, Florida, United States, 32503
      • Synexus Clinical Research US, Inc. | Pinellas Park, Florida, United States, 33781
      • USPA Advance Concept Medical Research Group LLC. | South Miami, Florida, United States, 33143
      • Precision Clinical Research | Sunrise, Florida, United States, 33351
      • Advanced Research | Tamarac, Florida, United States, 33321
      • University of South Florida | Tampa, Florida, United States, 33612
      • Alliance Clinical Research, LLC | Tampa, Florida, United States, 33615
      • Grady Memorial Hospital | Atlanta, Georgia, United States, 30303
      • Digestive Healthcare of Georgia | Atlanta, Georgia, United States, 30309
      • Columbus Regional Research Institute | Columbus, Georgia, United States, 31904
      • Gastrointestinal Specialists of Georgia | Marietta, Georgia, United States, 30060
      • Grand Teton Research Group | Idaho Falls, Idaho, United States, 83404
      • Eagle Clinical Research | Chicago, Illinois, United States, 60621
      • Qualmedica Research, LLC | Evansville, Indiana, United States, 47715
      • Indiana University Health | Indianapolis, Indiana, United States, 46202
      • Care Access Research - Terre Haute | Terre Haute, Indiana, United States, 47802
      • University of Kansas Medical Center | Kansas City, Kansas, United States, 66160
      • Robley Rex VA Medical Center | Louisville, Kentucky, United States, 40206
      • CroNola LLC | Houma, Louisiana, United States, 70360
      • Delta Research Partners LLC | Monroe, Louisiana, United States, 71201
      • Nola Research Works, LLC | New Orleans, Louisiana, United States, 70125
      • Louisiana Clinical Research, LLC | Shreveport, Louisiana, United States, 71105
      • MGG Group, Inc.., Co., Chevy Chase Clinical Research | Chevy Chase, Maryland, United States, 20815
      • Woodholme Gastroenterology Associates - Glen Burnie | Glen Burnie, Maryland, United States, 21061
      • Capital Digestive Care | Rockville, Maryland, United States, 20850
      • Tufts Medical Center | Boston, Massachusetts, United States, 02111
      • Clinical Research Institute of Michigan, LLC | Chesterfield, Michigan, United States, 48047
      • Henry Ford Health System | Detroit, Michigan, United States, 48202
      • Revive Research Institute | Farmington Hills, Michigan, United States, 48334
      • Infusion Associates | Grand Rapids, Michigan, United States, 49525
      • MNGI Digestive Health, P.A. | Plymouth, Minnesota, United States, 55446
      • Gastrointestinal Associates | Flowood, Mississippi, United States, 39232
      • University of Mississippi School of Medicine | Jackson, Mississippi, United States, 39216-4500
      • Southern Therapy and Advanced Research (STAR) LLC | Jackson, Mississippi, United States, 39216
      • Digestive Health Specialists | Tupelo, Mississippi, United States, 38801
      • BVL Research | Liberty, Missouri, United States, 64068
      • Advanced Biomedical Research of America - South Eastern Avenue | Las Vegas, Nevada, United States, 89123
      • Care Access - Las Vegas | Las Vegas, Nevada, United States, 89148
      • Lovelace Scientific Resources - Albuquerque | Albuquerque, New Mexico, United States, 87108
      • NYU Langone Long Island Clinical Research Associates | Lake Success, New York, United States, 11042
      • Care Access Research - Yonkers | Yonkers, New York, United States, 10701
      • Unc Hospitals | Chapel Hill, North Carolina, United States, 27599
      • Javara | Charlotte, North Carolina, United States, 28210
      • Medication Management | Greensboro, North Carolina, United States, 27405
      • Peters Medical Research | High Point, North Carolina, United States, 27262
      • Care Access Research-Kinston | Kinston, North Carolina, United States, 28501
      • Care Access Research-Lumberton | Lumberton, North Carolina, United States, 28358
      • Gastroenterology Associates of the Piedmont | Winston-Salem, North Carolina, United States, 27103
      • University Hospitals Cleveland Medical Center | Cleveland, Ohio, United States, 44106
      • Ohio State University Hospital | Columbus, Ohio, United States, 43210
      • Ohio Gastroenterology Group Inc. | Dublin, Ohio, United States, 43016
      • Northshore Gastroenterology Research, LLC | Westlake, Ohio, United States, 44145
      • University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma, United States, 73104
      • Care Access Research LLC | Pottsville, Pennsylvania, United States, 17901
      • Care Access Research - Scranton | Scranton, Pennsylvania, United States, 18508
      • University Gastroenterology | Providence, Rhode Island, United States, 02905
      • Radiant Research | Anderson, South Carolina, United States, 29621
      • Strand GI | Myrtle Beach, South Carolina, United States, 29572
      • Gastroenterology Associates of Orangeburg | Orangeburg, South Carolina, United States, 29118
      • Gastro One | Germantown, Tennessee, United States, 38138
      • GIA Clinical Trials, LLC | Knoxville, Tennessee, United States, 37909
      • Amel Med LLC | Austin, Texas, United States, 78750
      • Baylor Scott & White Center for Inflammatory Bowel Diseases | Dallas, Texas, United States, 75246
      • Advanced Gastroenterology Associates | Decatur, Texas, United States, 76234
      • University of Texas Medical Branch at Galveston | Galveston, Texas, United States, 77555
      • Baylor College of Medicine | Houston, Texas, United States, 77030
      • University of Texas Health Services Center - Houston | Houston, Texas, United States, 77030
      • Biopharma Informatic, LLC | Houston, Texas, United States, 77084
      • Katy Gastro Health & Nutrition | Katy, Texas, United States, 77494
      • Caprock Gastro Research, LLC | Lubbock, Texas, United States, 79424
      • Biopharma Informatic, LLC | McAllen, Texas, United States, 78503
      • Digestive System Healthcare | Pasadena, Texas, United States, 77505
      • Sun Research Institute | San Antonio, Texas, United States, 78215
      • Southern Star Research Institute, LLC | San Antonio, Texas, United States, 78229
      • VIP Trials | San Antonio, Texas, United States, 78230
      • Tyler Research Institute, LLC | Tyler, Texas, United States, 75701
      • Care Access Research LLC - Salt Lake City | Ogden, Utah, United States, 84403
      • Velocity Clinical Research/Gut Whisperer | Riverton, Utah, United States, 84065
      • Kalo Clinical Research | Salt Lake City, Utah, United States, 84102
      • Care Access Research LLC - Salt Lake City | Salt Lake City, Utah, United States, 84124
      • University of Virginia Health System | Charlottesville, Virginia, United States, 22908-0816
      • Pediatrics Specialists of Virginia | Fairfax, Virginia, United States, 22031
      • Children's Specialty Group, PPLC | Norfolk, Virginia, United States, 23507
      • The Center for Gastrointestinal Health | Petersburg, Virginia, United States, 23805
      • Clinical Research Partners, LLC | Richmond, Virginia, United States, 23226
      • Carilion Clinic | Roanoke, Virginia, United States, 24014
      • Virginia Gastroenterology Institute | Suffolk, Virginia, United States, 23434
      • TPMG Clinical Research Williamsburg | Williamsburg, Virginia, United States, 23188
      • Washington Gastroenterology, PLLC | Bellevue, Washington, United States, 98004
      • Advanced Clinical Research-Spokane Gastroenterology | Spokane, Washington, United States, 99202
      • Washington Gastroenterology, PLLC | Tacoma, Washington, United States, 98405
      • Marshall Medical Center | Huntington, West Virginia, United States, 25701
      • Care Access Research - Wyoming | Casper, Wyoming, United States, 82601
      • DOM- Centro de Reumatologia | Caba, Buenos Aires, Argentina, 1111
      • Mautalen Salud e Investigación | Caba, Buenos Aires, Argentina, C1128AAF
      • CEMIC- Servicio de Reumatología | Caba, Buenos Aires, Argentina, C1431FWO
      • Instituto Medico Elsa Perez SRL (IMEP) | Ciudadela, Buenos Aires, Argentina, 1702
      • CIPREC | Ciudad Autonoma de Buenos Aire, Ciudad Autónoma De Buenos Aire, Argentina, C1119ACN
      • Centro de Investigaciones Médicas Tucuman | SAN M. DE Tucuman, Tucumán, Argentina, T4000AXL
      • Centro de Investigaciones Metabólicas (CINME) | Buenos Aires, Argentina, C1027AAP
      • Concord Repatriation General Hospital | Concord, New South Wales, Australia, 2139
      • St. Vincents Hospital Sydney | Darlinghurst, New South Wales, Australia, 2010
      • Nepean Hospital | Kingswood, New South Wales, Australia, 2747
      • Liverpool Hospital | Liverpool, New South Wales, Australia, 2170
      • Royal Brisbane and Women's Hospital | Herston, Queensland, Australia, 4029
      • Coastal Digestive Health | Maroochydore, Queensland, Australia, 4558
      • Coral Sea Clinical Research Institute | North Mackay, Queensland, Australia, 4740
      • Emeritus Research | Camberwell, Victoria, Australia, 3124
      • Northern Hospital | Epping, Victoria, Australia, 3076
      • The Royal Melbourne Hospital | Parkville, Victoria, Australia, 3050
      • Fiona Stanley Hospital | Murdoch, Western Australia, Australia, 6150
      • Medizinische Universität Innsbruck | Innsbruck, Austria, 6020
      • Universitätsklinikum Salzburg | Salzburg, Austria, 5020
      • Krankenhaus der Barmherzigen Schwestern Wien | Wien, Austria, 1060
      • AKH | Wien, Austria, 1090
      • Imelda General Hospital | Bonheiden, Antwerpen, Belgium, 2820
      • Cliniques Universitaires Saint-Luc | Bruxelles, Brussel, Belgium, 1200
      • UZ Brussel | Brussel, Belgium, 1090
      • AZ Groeninge | Kortrijk, Belgium, 8500
      • Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven, Belgium, 3000
      • Cliagen - Clinica de Atencao em Gastroenterologia, Especialidades e Nutricao | Salvador, Bahia, Brazil, 41500-300
      • HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará | Fortaleza, Ceara, Brazil, 60430-370
      • L2IP - Instituto de Pesquisas Clinicas Ltda. | Brasília, Distrito Federal, Brazil, 70200-730
      • Chronos Pesquisa Clínica | Brasília, Distrito Federal, Brazil, 72145-450
      • Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda | Goiania, GO, Brazil, 74535-170
      • Hospital Felício Rocho | Belo Horizonte, MG, Brazil, 30110-934
      • Eurolatino Pesquisas Medicas Ltda. | Uberlandia, Minas Gerais, Brazil, 38411-186
      • Associacao Paranaense de Cultura - PUCPR | Curitiba, Parana, Brazil, 80230-130
      • Instituto de Pesquisa em Saúde - Fundação Universidade de Caxias do Sul | Caxias do Sul, Rio Grande Do Sul, Brazil, 95070-560
      • Hospital de Clínicas de Porto Alegre | Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
      • Irmandade da Santa Casa de Misericórdia de Porto Alegre | Porto Alegre, Rio Grande Do Sul, Brazil, 90050-170
      • Hospital Ernesto Dornelles | Porto Alegre, Rio Grande Do Sul, Brazil, 90160-093
      • Nucleo de Pesquisa Clínica do Rio Grande do Sul-NPCRS | Porto Alegre, Rio Grande Do Sul, Brazil, 90430-001
      • Hospital Moinhos de Vento | Porto Alegre, Rio Grande Do Sul, Brazil, 90560-030
      • HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas | Campinas, Sao Paulo, Brazil, 13060-904
      • Pesquisare | Santo Andre, Sao Paulo, Brazil, 09080-110
      • Faculdade de Medicina de Botucatu | Botucatu, SP, Brazil, 18618-687
      • Faculdade de Medicina do ABC | Santo Andre, SP, Brazil, 09060-870
      • Instituto de Assistencia Medica ao Servidor Publico Estudo Estadual | Sao Paulo, SP, Brazil, 04039-004
      • Praxis Pesquisa Medica | Santo Andre, São Paulo, Brazil, 09790790
      • CEMEC - Centro Multidisciplinar de Estudos Clinicos EPP Ltda | São Bernardo do Campo, São Paulo, Brazil, 09715-090
      • Hospital Gloria Dor | Rio de Janeiro, Brazil, 22211-230
      • Hospital Sírio Libanês | Sao Paulo, Brazil, 01308-050
      • Hepatogastro | Sao Paulo, Brazil, 04543-001
      • CPQuali Pesquisa Clínica | São Paulo, Brazil, 01228-000
      • Clinica Onco Star | São Paulo, Brazil, 04543-000
      • Gastroenterology and internal medicine research institute | Edmonton, Alberta, Canada, T5R 1W2
      • Fraser Clinical Trials Inc | New Westminster, British Columbia, Canada, V3L 3W4
      • The Medical Arts Health Research Group | North Vancouver, British Columbia, Canada, V7L 4W8
      • GI Research Institute | Vancouver, British Columbia, Canada, V6Z 2K5
      • Milestone Clinical | Dartmouth, Nova Scotia, Canada, B2W 6L4
      • K&M Medical | Kentville, Nova Scotia, Canada, B4N 0A3
      • London Health Sciences Centre | London, Ontario, Canada, N6A 5A5
      • Victoria Hospital | London, Ontario, Canada, N6A 5W9
      • Viable Clinical Research | Sudbury, Ontario, Canada, P3C 5K6
      • CIUSS-de-L'Est-de-l'île-de-Montréal-Hôpital | Montreal, Quebec, Canada, H1T 2M4
      • Anhui Provincial Hospital | Hefei, Anhui, China, 230001
      • Peking University First Hospital | Beijing, Beijing, China, 100034
      • Peking University Third Hospital | Beijing, Beijing, China, 100191
      • Chongqing General Hospital | Chongqing, Chongqing, China, 400014
      • The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA | Chongqing, Chongqing, China, 400037
      • The First Hospital Affiliated to AMU (Southwest Hospital) | Chongqing, Chongqing, China, 400038
      • The First Affiliated Hospital of Fujian Medical University | Fujian, Fuzhou, China, 350005
      • The First People's Hospital of Foshan | Foshan, Guangdong, China, 528000
      • First affiliated Hospital of Sun Yat-Sen University | Guangzhou, Guangdong, China, 510080
      • Sun Yat-sen Memorial Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China, 510120
      • The Sixth Affiliated Hospital, Sun Yat-Sen University | Guangzhou, Guangdong, China, 510655
      • Hainan General Hospital | Haikou, Hainan, China, 570311
      • Tongji Hosp Tongji Med Col Huazhong Univ of Sci & Tech | Wu Han, Hubei, China, 430030
      • Xiangya Hospital Central South University | Changsha, Hunan, China, 410008
      • The Second Xiangya Hospital of Central South University | Changsha, Hunan, China, 410011
      • The Third Xiangya Hospital of Central South University | Changsha, Hunan, China, 410013
      • The First People's Hospital of Changzhou | Changzhou, Jiangsu, China, 213003
      • Changzhou No.2 People's Hospital | Changzhou, Jiangsu, China,
      • Jiangsu Province Hospital of Chinese Medicine | Nanjing, Jiangsu, China, 210029
      • Jiangsu Province Hospital | Nanjing, Jiangsu, China, 210029
      • The Second Affiliated Hospital of Soochow University | Suzhou, Jiangsu, China, 215004
      • The First Affiliated Hospital of Soochow University | Suzhou, Jiangsu, China, 215066
      • Wuxi People's Hospital | Wuxi, Jiangsu, China, 214023
      • Affiliated Hospital of Jiangsu University | Zhenjiang, Jiangsu, China, 212000
      • The First Affiliated Hospital of Nanchang University | Nanchang, Jiangxi, China, 330006
      • The First Hospital of China Medical University | Shenyang, Liaoning, China, 110001
      • Shengjing Hospital of China Medical University | Shenyang, Liaoning, China, 110004
      • Shanghai East Hospital | Shanghai, Pudong District, China, 200120
      • Shanghai Jiaotong University School of Medicine Ruijin Hospital | Shanghai, Shanghai, China, 200025
      • Zhongshan Hospital, Fudan University | Shanghai, Shanghai, China, 200032
      • Shanghai 6th people's hospital | Shanghai, Shanghai, China,
      • West China Hospital of Sichuan University | Cheng Du, Sichuan, China, 610041
      • Tianjin Medical University General Hospital | Tianjin, Tianjin, China, 300052
      • First Affiliated Hospital of Kunming Medical University | Kunming, Yunnan, China, 650032
      • The First People's Hospital of Yunnan Province | Kunming, Yunnan, China, 650034
      • First Affiliated Hosp of College of Med, Zhejiang University | Hangzhou, Zhejiang, China, 310003
      • The Second Affiliated Hospital of Zhejiang University School of Medicine | Hangzhou, Zhejiang, China, 310009
      • Sir Run Run Shaw Hospital | Hangzhou, Zhejiang, China, 310016
      • The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university | Wenzhou, Zhejiang, China, 310015
      • Zhongshan Hospital Xiamen University | Xiamen, China, 361004
      • Clinical Medical Centre Osijek | Osijek, Croatia, 31000
      • CHC Zagreb | Zagreb, Croatia, 10000
      • Vojenská Nemocnice Brno | Brno, Brno-město, Czechia, 636 00
      • Krajska zdravotni, a.s.-Masarykova nemocnice Usti nad Labem | Usti nad Labem, Czech Republic, Czechia, 40113
      • Hepato-Gastroenterologie HK | Hradec Kralove, Hradec Králové, Czechia, 500 12
      • MUDr. Gregar, s.r.o. | Olomouc, Olomoucký Kraj, Czechia, 779 00
      • Institut Klinicke a Experimentalni Mediciny | Praha 4, Prague, Czechia, 14021
      • Synexus Czech | Prague, Praha 2, Czechia, 120 00
      • Thomayerova nemocnice | Prague, Praha 4, Czechia, 14059
      • Nemocnice Tomase Bati ve Zline | Zlín, Zlínský Kraj, Czechia, 762 75
      • Fakultni Nemocnice U svate Anny | Brno, Czechia, 65691
      • Oblastni nemocnice Nachod-Endoskopicke centrum | Nachod, Czechia,
      • PreventaMed, s.r.o. | Olomouc, Czechia, 77900
      • MUDr. Radka Koskova, s.r.o., Gastroenterologicka ambulance | Ostrava - Muglinov, Czechia, 712 00
      • A-Shine, s.r.o. | Plzen, Czechia, 301 00
      • AXON Clinical | Praha 5, Czechia, 150 00
      • Mediendo, s.r.o. | Praha 8, Czechia, 18600
      • ISCARE Clinical Centre | Praha 9, Czechia, 19000
      • Aarhus Universitetshospital, Skejby | Aarhus, Midtjylland, Denmark, 8200
      • Aalborg Hospital | Aalborg, Denmark, 9100
      • Hopital de Hautepierre - Service d'Hépatogastroentérolgie | Strasbourg Cedex, Bas Rhin, France, 67098
      • Hôpital Saint Antoine | Paris, Cedex 12, France, 75012
      • Hôpital Beaujon | Clichy, Paris, France, 92110
      • Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre | Le Kremlin-Bicêtre, Paris, France, 94270
      • Hospices Civils de Lyon - Centre Hospitalier Lyon Sud - | Pierre Benite cedex, Rhone, France, 69495
      • CHU Amiens Picardie Site Sud - Service d'Hepato-gastro-entérologie | Amiens, France, 80054
      • Centre Hospitalier du Mans | Le Mans, France, 72000
      • CHRU de Montpellier-Hopital St Eloi | Montpellier Cedex 5, France, 34295
      • GH Necker - Enfants Malades | Paris, France, 75015
      • CHU Bordeaux - Hôpital Haut-Lévêque | Pessac Cedex, France, 33604
      • CHU de Poitiers- Service d'Hépato-gastro-entérologie, | Poitiers Cedex, France, 86021
      • CHU Charles Nicolle in Rouen | Rouen cedex, France, 76036
      • CHU St Etienne Hopital Nord | Saint Etienne Cedex 2, France, 42055
      • CHRU de Nancy | Vand?uvre-lès-Nancy, France, 54511
      • Siloah St. Trudpert Klinikum-Zentrum für Innere Medizin | Pforzheim, Baden-Württemberg, Germany, 75179
      • Universitätsklinikum Würzburg A. ö. R. | Würzburg, Bayern, Germany, 97080
      • Synexus Clinical Research GmbH | Frankfurt am Main, Hessen, Germany, 60313
      • Krankenhaus Eichhof | Lauterbach, Hessen, Germany, 36341
      • Medizinische Hochschule Hanover | Hannover, Niedersachsen, Germany, 30625
      • Knappschaftskrankenhaus Bottrop | Bottrop, Nordrhein Westfalen, Germany, 46242
      • Universitaetsklinikum Essen | Essen, North Rhine-Westphalia, Germany, 45147
      • Johanna Etienne Krankenhaus-Klinik für Allgemeine Innere Medizin | Neuss, North Rhine-Westphalia, Germany, 41462
      • Gemeinschaftspraxis Jakobeit | Wipperfurth, North Rhine-Westphalia, Germany, 51688
      • St. Marienkrankenhaus-Medizinische Klinik I | Ludwigshafen, Rhineland-Palatinate, Germany, 67067
      • Practice Dr.med. Denger and Dr.med. Pfitzner | Friedrichsthal, Saarland, Germany, 66299
      • Studiengesellschaft BSF Unternehmergesellschaft | Halle (Saale),, Sachsen Anhalt, Germany, 06108
      • Synexus Clinical Research GmbH-Leipzig Research Centre | Leipzig, Saxony-Anhalt, Germany, 04103
      • Universitätsklinikum Schleswig-Holstein | Kiel, Schleswig-Holstein, Germany, 24105
      • RED-Institut GmbH | Oldenburg, Schleswig-Holstein, Germany, 23758
      • Charité Campus Virchow-Klinikum | Berlin, Germany, 12200
      • Synexus Clinical Research GmbH | Berlin, Germany, 12627
      • Florence-Nightingale-Krankenhaus | Düsseldorf, Germany, 40489
      • HaFCED - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen | Hamburg, Germany, 20251
      • Gastroenterologische Gemeinschaftspraxis Mainz | Mainz, Germany, 55122
      • Tumorzentrum Nordthüringen | Uslar, Germany, 99734
      • Synexus Gyula | Gyula, Bekes, Hungary, 5700
      • SZTE AOK Belgyogyaszati Klinika | Szeged, Csongrad, Hungary, 6725
      • DRC Gyogyszervizsgalo Kozpont Kft. | Balatonfüred, EU, Hungary, 8230
      • Clinexpert Tatabánya Ltd. | Tatabánya, Komárom-Esztergom, Hungary, H-2800
      • Clinexpert SMO | Budapest, Hungary, 1033
      • Synexus Magyarorszag Kft. | Budapest, Hungary, 1036
      • Pannonia Maganorvosi Centrum | Budapest, Hungary, 1136
      • Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház | Békéscsaba, Hungary, 5600
      • Bugát Pál Kórház | Gyöngyös, Hungary, 3200
      • Endomedix Diagnosztikai Központ - Miskolc | Miskolc, Hungary, 3526
      • CLINFAN Szolgáltató Kft | Szekszard, Hungary, 7100
      • All India Institute of Medical Sciences | New Delhi, Delhi, India, 110029
      • Sir Ganga Ram Hospital | New Delhi, Delhi, India, 110060
      • Gujarat Hospital - Gastro and Vascular Centre | Surat, Gujarat, India, 395009
      • International Gastro Institute | Vadodara, Gujarat, India, 390007
      • Midas Multispeciality Hospital Pvt.Ltd. | Nagpur, Maharashtra, India, 440010
      • Ruby Hall Clinic and Grant Medical Foundation | Pune, Maharashtra, India, 411001
      • Dayanand Medical College and Hospital | Ludhiana, Punjab, India, 141001
      • SR Kalla Memorial Gastro & General Hospital | Jaipur, Rajasthan, India, 302006
      • Apollo Speciality Hospital - Teynampet | Chennai, Tamil Nadu, India, 600035
      • Asian Institute of Gastroenterology | Hyderabad, Telangana, India, 500032
      • Postgraduate Institute of Medical Education & Research | Chandigarh, India, 160012
      • Aakash Healthcare Super Speciality Hospital | New Delhi, India, 110075
      • Gandhi Hospital | Telangana, India, 500003
      • Yashoda Super Speciality Hospital | Telangana, India, 500003
      • Soroka Medical Center | Beer Sheva, Israel, 8410101
      • Bnai Zion Medical Center | Haifa, Israel, 31048
      • Edith Wolfson Medical Center | Holon, Israel, 5822012
      • Shaare Zedek Medical Center | Jerusalem, Israel, 91031
      • Hadassah Medical Center | Jerusalem, Israel, 9112001
      • Galilee Medical Center Department of Internal Medicine A | Nahariya, Israel, 22100
      • Chaim Sheba Medical Center | Ramat Gan, Israel, 5262100
      • Kaplan Medical Center | Rehovot, Israel, 7610001
      • Assaf Harofeh Medical Center | Zerifin, Israel, 70300
      • Azienda Ospedaliera Saverio De Bellis | Castellana Grotte, Bari, Italy, 70013
      • Università di Cagliari - Presidio Policlinico Monserrato | Monserrato, Cagliari, Italy, 09042
      • Azienda ospedaliero-universitaria Mater Domini | Germaneto, Catanzaro, Italy, 88100
      • Policlinico Gemelli - Università Cattolica del Sacro Cuore | Roma, Lazio, Italy, 00168
      • Presidio di Rho | Rho, Milano, Italy, 20017
      • Istituto Clinico Humanitas | Rozzano, Milano, Italy, 20089
      • Ospedale Clinicizzato San Donato | San Donato Milanese, Milan, Italy, 20097
      • Istituto Mangiagalli | Milano, MI, Italy, 20122
      • Azienda Ospedaliera Policlinico Consorziale | Bari, Italy, 70124
      • Università degli Studi c/o Spedali Civili | Brescia, Italy, 25100
      • Azienda Ospedaliera Giuseppe Brotzu | Cagliari, Italy, 09134
      • Ospedale Luigi Sacco | Milano, Italy, 20157
      • Azienda Ospedaliera Universitaria Policlinico de Modena | Modena, Italy, 41124
      • Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli | Napoli, Italy, 80131
      • Azienda Ospedaliera Universitaria Federico II | Napoli, Italy, 80131
      • Arcispedale Santa Maria Nuova | Reggio Emilia, Italy, 42123
      • Polic.Umberto I -Univ. La Sapienza | Roma, Italy, 00161
      • Azienda Ospedaliera Santa Maria Della Misericordia | Udine, Italy, 33100
      • Kojunkai Daido Clinic | Nagoya, Aichi, Japan, 4570818
      • Fujita Health University | Toyoake, Aichi, Japan, 470-1192
      • National Hospital Organization Hirosaki General Medical Center | Hirosaki, Aomori, Japan, 036-8545
      • Tsujinaka Hospital | Kashiwa, Chiba, Japan, 277 0871
      • Fukuoka University Chikushi Hospital | Chikushino, Fukuoka, Japan,
      • Fukuoka University Hospital | Fukuoka, Jonan-Ku, Fukuoka, Japan, 814-0180
      • Hoshi General Hospital | Koriyama, Fukushima, Japan, 963-8501
      • Isesakishimin Hospital | Isesaki, Gunma, Japan, 372-0817
      • Kiryu Kosei Hospital | Kiryu, Gunma, Japan, 376 0024
      • Maebashi Red Cross Hospital | Maebashi, Gunma, Japan, 371 0811
      • National Hospital Organization Fukuyama Medical Center | Fukuyama, Hiroshima, Japan, 720-0825
      • Asahikawa Medical College Hospital | Asahikawa, Hokkaido, Japan, 078-8510
      • Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital | Chuo-ku, Sapporo-shi, Hokkaido, Japan, 060-0033
      • Tokushukai Sapporo Tokushukai Hospital | Sapporo-shi, Hokkaido, Japan, 004 0041
      • Sapporo Higashi Tokushukai Hospital | Sapporo, Hokkaido, Japan, 065-0033
      • Sapporo Medical University Hospital | Sapporo, Hokkaido, Japan,
      • Hyogo College of Medicine | Nishinomiya, Hyogo, Japan, 663-8501
      • Ibaraki Prefectural Central Hospital | Kasama, Ibaraki, Japan, 890-8520
      • Kanazawa University Hospital | Kanazawa, Ishikawa, Japan, 920-8641
      • Kagawa Prefectural Central Hospital | Takamatsu, Kagawa, Japan, 760-8557
      • Ofuna Central Hospital | Kamakura, Kanagawa, Japan, 247-0056
      • Kitasato University Hospital | Sagamihara, Kanagawa, Japan, 252-0375
      • Matsushima Cinic | Yokohama, Kanagawa, Japan, 220-0045
      • Mie University Hospital | Tsu, Mie, Japan, 514-8507
      • IMS Meirikai Sendai General Hospital | Sendai, Miyagi, Japan, 980-0021
      • Takagi Clinic - Sendai | Sendai, Miyagi, Japan, 981-3213
      • Nagasaki Harbor Medical Center | Nagasaki City, Nagasaki, Japan, 850-0842
      • Infusion Clinic | Osaka-shi, Osaka-Fu, Japan, 530-0011
      • Saga-Ken Medical Center Koseikan | Saga-shi, Saga, Japan, 840 8571
      • Matsuda Hospital | Hamamatsu-shi, Shizuoka-Ken, Japan, 4328061
      • Jichi Medical University Hospital | Shimotsuke, Tochigi, Japan, 329-0498
      • Tokyo Medical and Dental University Hospital | Bunkyō, Tokyo, Japan, 113-8519
      • Showa University Koto Toyosu Hospital | Koto-ku, Tokyo, Japan, 135 8577
      • National Center for Global Health and Medicine | Shinjuku-ku, Tokyo, Japan, 162-8655
      • JHCO Tokyo Yamate Medical Center | Shinjuku-ku, Tokyo, Japan, 169-0073
      • Tottori University Hospital | Yonago, Tottori, Japan, 683-8504
      • Kagoshima University Hospital | Kagoshima, Japan, 890-8520
      • Sameshima Hospital | Kagoshima, Japan, 892-0846
      • Kumamoto University Hospital | Kumamoto, Japan, 860-8556
      • Kyoto Furitsu Medical University Hospital | Kyoto, Japan, 602-8566
      • Okayama Saiseikai General Hospital Outpatient Center | Okayama, Japan, 700-0013
      • Okayama University Hospital | Okayama, Japan, 700-8558
      • Tokitokai Tokito Clinic | Saitama, Japan, 336-0963
      • Toyama Prefectural Central Hospital | Toyama, Japan, 930-8550
      • Yamagata University Hospital | Yamagata, Japan, 990-9585
      • Ajou University Hospital | Suwon, Gyeonggi-do, Korea, Republic of, 16499
      • Hanyang University Guri Hospital | Guri-si, Gyeonggido, Korea, Republic of, 11923
      • Kyung Pook National University Hospital | Daegu, Korea, Korea, Republic of, 41944
      • Kyung Hee University Hospital | Seoul, Korea, Korea, Republic of, 02447
      • Seoul St. Mary's Hospital | Seoul, Korea, Korea, Republic of, 06591
      • Kyunghee University Hospital at Gangdong | Seoul, Korea, Korea, Republic of, 134727
      • Yeungnam Univeristy Medical Center | Gyeongsan-si, Kyǒngsangbuk-do, Korea, Republic of, 42415
      • Seoul National University Hospital | Seoul, Seoul, Korea, Korea, Republic of, 03080
      • Asan Medical Center | Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of, 05505
      • The Catholic University of Korea, Daejeon St. Mary's Hospital | Daejeon, Taejǒn-Kwangyǒkshi, Korea, Republic of, 34943
      • Inje University Haeundae Paik Hospital | Busan, Korea, Republic of, 48108
      • Dong-A University Hospital | Busan, Korea, Republic of, 49201
      • Kyungpook National University Medical Center Chilgok Hospital | Daegu, Korea, Republic of, 41404
      • Keimyung University Dongsan Hospital | Daegu, Korea, Republic of, 42601
      • Yonsei University Wonju Severance Christian Hospital | Gangwon-do, Korea, Republic of, 26426
      • Korea University Ansan Hospital | Gyeonggi-do, Korea, Republic of, 15355
      • Kangbuk Samsung Hospital | Seoul, Korea, Republic of, 03181
      • Samsung Medical Center | Seoul, Korea, Republic of, 06351
      • Chungang University Hospital | Seoul, Korea, Republic of, 06973
      • Seoul National University Hospital | Seoul, Korea, Republic of, 3080
      • Pauls Stradins Clinical Univeristy Hospital | Riga, Rīga, Latvia, LV-1002
      • Hospital of Lithuanian University of Health Sciences Kaunas | Kaunas, Lithuania, 50009
      • Health Pharma Professional Research S.A. de C.V: | Ciudad de México, Distrito Federal, Mexico, 03100
      • Grupo Medico Camino Sc | México City, Distrito Federal, Mexico, 03310
      • PanAmerican Clinical Research S.A.de C.V. Guadalajara | Guadalajara, JA, Mexico, 44670
      • Hospital Universitario "Dr. Jose Eleuterio Gonzalez" | Monterrey, Nuevo Leon, Mexico, 64460
      • PanAmerican Clinical Research Mexico S.A. de C.V. | Santiago de Queretaro, Queretaro, Mexico, 76226
      • Scientia Investigacion Clinica S.C. | Chihuahua, Mexico, 31203
      • Instituto de Investigaciones Clínicas para la Salud | Durango, Mexico, 34000
      • Centro de Alta Especialidad Reumatologia Inv del Potosi SC | San Luis Potosi, Mexico, 78213
      • Sociedad de Metabolismo y Corazon | Veracruz, Mexico, 91900
      • ETZ Elisabeth Tilburg | Tilburg, North Brabant, Netherlands, 5022 GC
      • Bernhoven Uden | Uden, Netherlands, 5406 PT
      • MED-ROZ | Karwiany, Dolnośląskie, Poland, 52-200
      • Melita Medical | Wroclaw, Dolnośląskie, Poland, 50-449
      • Dc-Med. Sp. z o.o. | Swidnica, Lower Silesian, Poland, 58-100
      • M. Sklodowskiej-Curie 12 | Wroclaw, Lower Silesian, Poland, 50-381
      • ZOZ Gastromed | Lublin, Lubelskie, Poland, 20-582
      • NZOZ Vivamed | Warsaw, Mazowieckie, Poland, 03-580
      • Topolowa Medicenter | Krakow, Małopolskie, Poland, 31-506
      • Medicenter Nowy Targ | Nowy Targ, Małopolskie, Poland, 34-400
      • NZOZ Formed | Wadowice, Małopolskie, Poland, 34-100
      • Private Practice - Dr. Korczowski Bartosz | Rzeszow, Podkarpackie, Poland, 35-302
      • Nova Reuma Społka Partnerska | Bialystok, Podlaskie, Poland, 15-707
      • Synexus Polska Gdansku | Gdansk, Pomorskie, Poland, 80-382
      • Synexus Polska Sp. z o.o. Oddzial w Gdyni | Gdynia, Pomorskie, Poland, 81-537
      • Endoskopia Sp. z.o.o. | Sopot, Pomorskie, Poland, 81-756
      • Kiepury Clinic | Sosnowiec, Silesian, Poland, 41-200
      • Centrum Medyczne Medyk | Rzeszow, Subcarpathian, Poland, 35-326
      • Sonomed Sp. z o.o. | Szczecin, West Pomeranian, Poland, 71-685
      • Synexus Polska Sp. z o.o. Oddzial w Poznaniu | Poznan, Wielkopolskie, Poland, 60-702
      • Instytut Pomnik-Centrum Zdrowia Dziecka | Warszawa, Woj Mazowieckie, Poland, 04-730
      • Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy | Bydgoszcz, Poland, 85-168
      • NZOZ "Twoje Zdrowie EL" Sp. z o.o. | Elblag, Poland, 82-300
      • Indywidualna Specjalistyczna Praktyka Lekarska | Knurow, Poland, 44-190
      • Synexus Polska Oddział w Lodzi | Lodz, Poland, 90-127
      • Twoja Przychodnia - Szczecinskie Centrum Medyczne | Szczecin, Poland, 71-434
      • WIP Warsaw IBD Point Profesor Kierkus | Warszawa, Poland, 00-728
      • ETG Zamość | Zamosc, Poland, 22-400
      • Centrum Medyczne SYNEXUS | Czestochowa, Śląskie, Poland, 42-202
      • Synexus Polska - Katowicach | Katowice, Śląskie, Poland, 40040
      • Caguas Gastroenterology and Hepatology Center, LLC | Caguas, Puerto Rico, 00726-4980
      • Pan American Center for Oncology Trials | Rio Piedras, Puerto Rico, 00935
      • Latin Clinical Trial Center | San Juan, Puerto Rico, 00909
      • Wellness clinical Research Vega Baja | Vega Baja, Puerto Rico, 00694
      • Spitalul Pelican | Oradea, Bihor, Romania, 410450
      • Spitalul Euroclinic | Bucureti, București, Romania, 014461
      • Sc Tvm Med Serv | Cluj-Napoca, Cluj, Romania, 400132
      • SC Med Life SA | Bucuresti, Romania, 010719
      • Spitalul Clinic CF 2 Bucuresti | Bucuresti, Romania, 011464
      • S.C. Centrul Medical Medicum SRL | Bucuresti, Romania, 012015
      • Institutul Clinic Fundeni | Bucuresti, Romania, 022328
      • Spitalul Clinic Colentina | Bucuresti, Romania, 21155
      • CCBR Clinical Research | Bucuresti, Romania, 30463
      • Spitalul Universitar de Urgență București | București, Romania, 050098
      • Gastromed S.R.L. | Constanta, Romania, 900168
      • Affidea Medical Research Center | Constanta, Romania, 900591
      • Spitalul Clinic Judetean Targu Mures | Targu Mures, Romania, 540103
      • S.C. Materna Care S.R.L. | Timisoara, Romania, 300645
      • Scientific Centre of Reconstructive and Restorative Surgery | Irkutsk, Irkutskaya Oblast', Russian Federation, 664079
      • Karelia Republican Hospital V.A. Baranova | Petrozavodsk, Kareliya, Respublika, Russian Federation, 185019
      • Olla-Med | Moscow, Moskva, Russian Federation, 105554
      • Nizhny Novgorod Regional Hospital N.A. Semashko | Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation, 603126
      • Novosibirski Gastrocenter | Novosibirsk, Novosibirskaya Oblast', Russian Federation, 630007
      • Rostov State Medical University | Rostov-on-Don, Rostovskaya Oblast', Russian Federation, 344091
      • LLC Medical Center Reavita Med SPb | Saint Petersburg, Sankt-Peterburg, Russian Federation, 194354
      • Scientific research center ECO-security | Saint Petersburg, Sankt-Peterburg, Russian Federation, 196143
      • Multidisciplinary Medical Clinic "Anthurium" | Barnaul, Russian Federation, 656043
      • LLC Evimed | Chelyabinsk, Russian Federation, 454048
      • Medical and Sanitary Division of Severstal | Cherepovets, Russian Federation, 162600
      • LLC MA New Hospital | Ekaterinburg, Russian Federation, 620109
      • Clinical Trials Center of Medical Institute | Kaliningrad, Russian Federation, 236035
      • Kazan State Medical University | Kazan, Russian Federation, 420029
      • SIH Kemerovo Regional Clinical Hosptial | Kemerovo, Russian Federation, 650066
      • LLC ?Medsanchast No 14? | Moscow, Russian Federation, 123022
      • State Scientific Centre of Coloproctology | Moscow, Russian Federation, 123423
      • LLC "Medicine Center SibNovoMed" | Novosibirsk, Russian Federation, 630005
      • The University Clinic of OSMU | Omsk, Russian Federation, 644050
      • Saint-Petersburg City Hospital of Saint Elizabeth | Saint Petersburg, Russian Federation, 195257
      • Pokrovskaya Municipal Hospital | Saint-Petersburg, Russian Federation, 195067
      • LLC Gastroenterology Centre Expert | Saint-Petersburg, Russian Federation, 197110
      • SBIH City Clinical Hospital #31 | Saint-Petersburg, Russian Federation, 197110
      • SPb SBIH "City Polyclinic # 106" | Saint-Petersburg, Russian Federation, 198328
      • NonState Healthcare Institution Central Clinical Hospital | Samara, Russian Federation, 443029
      • Academician I.P. Pavlov First St-Petersburg State Medical University | St-Petersburg, Russian Federation, 197022
      • Clinical Hospital Center Zvezdara | Belgrade, Beograd, Serbia, 11000
      • Zemun Medical Centre | Zemun, Beograd, Serbia, 11080
      • University Medical Center "Bezanijska kosa" | Belgrade, NAP, Serbia, 11080
      • Clinical Center Nis | Nis, Nišavski Okrug, Serbia, 18000
      • Sremska Mitrovica Health Centre | Sremska Mitrovica, Vojvodina, Serbia, 22000
      • General Hospital "Djordje Joanovic" | Zrenjanin, Vojvodina, Serbia, 23000
      • Clinical Center " Dr Dragisa Misovic Dedinje" | Belgrade, Serbia, 11000
      • Clinical Center Kragujevac Gastroenterohepatology Clinic | Kragujevac, Serbia, 34000
      • Gastro | Prešov, Prešovský Kraj, Slovakia, 080 01
      • Endomed, s.r.o. | Vranov N. Toplou, Prešovský Kraj, Slovakia, 093 01
      • FNsP FDRoosevelta Banska Bystrica | Banska Bystrica, Slovakia, 97517
      • CLINIQ, s.r.o | Bratislava, Slovakia, 811 09
      • Gastromedic | Nove Zamky, Slovakia, 94002
      • Gastro LM s.r.o. | Presov, Slovakia, 08001
      • Clínica Gaias - Santiago | Santiago de Compostela, A Coruña [La Coruña], Spain, 15702
      • Hospital Universitario Central de Asturias | Oviedo, Asturias, Spain, 33011
      • Hospital Universitari de Girona Dr. Josep Trueta | Girona, Barcelona, Spain, 17007
      • Complejo Hospitalario de Navarra NAVARRABIOMED UNIDAD EC | Pamplona, Navarra, Spain, 31008
      • Instituto de Ciencias Médicas | Alicante, Spain, 3004
      • Centro Medico Teknon - DIGESTIVO | Barcelona, Spain, 8022
      • Hospital Reina Sofia | Cordoba, Spain, 14004
      • Complexo Hospitalario Universitario A Coruña, CHUAC | La Coruña, Spain, 15006
      • Hospital De Gran Canaria Dr. Negrin | Las Palmas de Gran Canaria, Spain, 35010
      • Hospital La Princesa | Madrid, Spain, 28006
      • Hospital Universitario La Paz | Madrid, Spain, 28046
      • Hospital Universitario Nuestra Señora de la Candelaria | Santa Cruz de Tenerife, Spain, 38010
      • Cantonal Hospital St.Gallen | St. Gallen, Sankt Gallen, Switzerland, 9007
      • Inselspital Bern | Bern, Switzerland, 3010
      • Gastroenterologische Praxis Balsiger, Seibold & Partner | Bern, Switzerland, CH-3012
      • Antalya Egitim ve Arastırma Hastanesi | Kocaeli, Antalya, Turkey, 7100
      • Acibadem Universitesi - Acibadem Kozyatagi Hastanesi | Kadıkoy, Istanbul, Turkey, 34734
      • Mersin University Medical Faculty | Yenişehir, Mersin, Turkey, 33343
      • Hacettepe University Faculty of Medicine | Ankara, Turkey, 06100
      • Ankara City Hospital | Ankara, Turkey, 06800
      • Gazi University Faculty of Medicine | Ankara, Turkey,
      • Uludag Universitesi | Bursa, Turkey, 16059
      • Trakya University | Edirne, Turkey, 22030
      • Eskisehir Osmangazi University Gastroenterology | Eskisehir, Turkey, 26040
      • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi | Gaziantep, Turkey, 27310
      • Mustafa Kemal Universitesi Tayfur Ata Sokmen Tip Fakultesi | Hatay, Turkey, 31040
      • Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi Yerleskesi | Istanbul, Turkey, 34098
      • Marmara University Pendik Research and Training Hospital | Istanbul, Turkey, 34340
      • Medicana Kadiköy Hastanesi | Istanbul, Turkey, 34724
      • Fulya Acıbadem | Istanbul, Turkey,
      • Dokuz Eylül Üniversitesi | Izmir, Turkey, 35340
      • Kocaeli University Medical Faculty Hospital | Izmit, Turkey, 41380
      • Erciyes University Hospital | Kayseri, Turkey, 38039
      • Konya Necmettin Erbakan Gastroenterology | Konya, Turkey, 42080
      • Inonu Universitesi Turgut Ozal Tıp Merkezi | Malatya, Turkey, 44280
      • City Clinical Hospital No. 2 | Kharkiv, Kharkivska Oblast, Ukraine, 61037
      • Medical Center of Limited Liability Company "Medical Center "Consilium Medical" | Kiev, Kyiv, Ukraine, 4050
      • Lviv Railway Clinical Hospital | Lviv, Lvivska Oblast, Ukraine, 79000
      • Lviv Regional Endocrinology Dispensary | Lviv, Lvivska Oblast, Ukraine, 79000
      • RCI Chernivtsi Regional Clinical Hospital | Chernivtsi, Ukraine, 58002
      • Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine | Dnipro, Ukraine, 49038
      • Ivano-Frankivsk State Medical University | Ivano-Frankivsk, Ukraine, 76018
      • Kharkiv Regional Council Regional Clinical Hospital | Kharkiv, Ukraine, 61058
      • Medical Centre of Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV | Kyiv, Ukraine, 01030
      • International Institute of Clinical Trials LLC | Kyiv, Ukraine, 02091
      • LLC Medbud-Clinic Medical Center | Kyiv, Ukraine, 03037
      • Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrainian Railway | Kyiv, Ukraine, 03049
      • Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary" | Kyiv, Ukraine, 04078
      • Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary" | Kyiv, Ukraine, 04107
      • Communal Enterprise "Odesa Regional Clinical Hospital" | Odesa, Ukraine, 65117
      • A. Novak Transcarpathian Regional Clinical Hospital | Uzhgorod, Ukraine, 88000
      • Medical Center "Health Clinic" LLC | Vinnitsa, Ukraine, 21009
      • Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU | Vinnytsia, Ukraine, 21005
      • CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM | Vinnytsia, Ukraine, 21029
      • Vinnytsya Regional Clinical Hospital | Vinnytsya, Ukraine, 21018
      • Zaporozhye City Clinical Hospital #6 | Zaporizhzhia, Ukraine, 69000
      • Diacenter LLC | Zaporizhzhia, Ukraine, 69076
      • Addenbrookes Hospital | Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ
      • Whipps Cross University Hospital | London, England, United Kingdom, E11 1NR
      • Synexus Manchester Clinical Research Centre | Manchester, Greater Manchester, United Kingdom, M15 6SE
      • Chelsea and Westminster Hospital | Fulham, London, United Kingdom, SW10 9NH
      • Synexus Wales Clinical Research Centre | Cardiff, South Glamorgan, United Kingdom, CF15 9SS
      • Synexus Midlands Clinical Research Center | Birmingham, Wstmid, United Kingdom, B15 2SQ
      • Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust | Doncaster, United Kingdom, DN2 5LT
      • Paediatric Clinical Research Facility Royal Hospital for Children and Young People | Edinburgh, United Kingdom, EH16 4TJ
      • Synexus North East Clinical Research Centre | Hexham, United Kingdom, NE46 1QJ
      Investigators

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        Additional Information

        Additional Relevant MeSH Terms

        • Crohn Disease
        • Inflammatory Bowel Diseases
        • Gastroenteritis
        • Gastrointestinal Diseases
        • Digestive System Diseases
        • Intestinal Diseases