A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation

ClinicalTrials.gov processed this data on June 18, 2024. Link to the current ClinicalTrials.gov record.

Recruitment Status

ACTIVE, NOT RECRUITING (See Contacts and Locations)
Verified June 2024 by Mirati Therapeutics Inc.

Sponsor

Mirati Therapeutics Inc.

Information Provided by (Responsible Party)

Mirati Therapeutics Inc.

Clinicaltrials.gov Identifier

NCT04685135
Other Study ID Numbers: CA239-0013
First Submitted: December 21, 2020
First Posted: December 28, 2020
Last Update Posted: June 21, 2024
Last Verified: June 2024
History of Changes

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Study Description

Not Provided
Condition or Disease Intervention/Treatment
  • Metastatic Non Small Cell Lung Cancer
  • Advanced Non Small Cell Lung Cancer
  • Drug: MRTX849
  • Drug: Docetaxel

Study Design

Study TypeInterventional
Actual Enrollment453 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingNone (Open Label)
Primary PurposeTreatment
Official TitleA Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
Study Start DateApril 1, 2021
Actual Primary Completion DateDecember 30, 2023
Anticipated Study Completion DateDecember 31, 2024

Groups and Cohorts

Group/ CohortIntervention/ Treatment
  • MRTX849
  • Drug: MRTX849
    • 21 day cycles
  • Docetaxel
  • Drug: Docetaxel

    Outcome Measures

    Primary Outcome Measures

    1. Progression-free Survival (PFS) [32 Months]
      Defined as time from randomization until disease progression or death from any cause, whichever occurs first.

    Secondary Outcome Measures

    1. Overall Survival (OS) [49 Months]
      Defined as time from date of randomization to date of death due to any cause.
    2. Objective Response Rate (ORR) [32 Months]
      Defined as the percent of patients documented to have a confirmed CR or PR.
    3. Duration of Response (DOR) [49 Months]
      Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.
    4. 1-year Survival Rate [49 Months]
    5. Safety [49 Months]
      characterized by type, incidence, severity, timing, seriousness and relationship to study treatment of AEs, laboratory abnormalities, and number of patients discontinuing study treatment due to an adverse event.
    6. Population PK parameters of MRTX849 [49 Months]
      Data for this Outcome Measure will not be reported here but will be used in a Population PK Analysis which will include participants who were not enrolled in this study, and issued in a separate report. ClinicalTrials.gov is designed for reporting results from only those participants who were enrolled in the study and described in the Participant Flow and Baseline Characteristics modules
    7. Patient Reported Outcomes (PROs) [49 Months]
      To be assessed by Lung Cancer Symptom Scale (LCSS).
    8. Quality of LIfe Assessment [49 Months]
      To be assessed by European Quality of Life Five Dimensions Questionnaire (EQ-5D-5L).

    Eligibility Criteria

    Ages Eligible for Study 18 Years and Older (Adult, Older Adult)
    Sexes Eligible for Study All
    Accepts Healthy Volunteers No
    Inclusion Criteria
    • Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
    • Candidacy to receive treatment with docetaxel.
    • Crossover Inclusion Criteria:
    • Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
    • ECOG performance status 0-2
    Exclusion Criteria
    • Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
    • Active brain metastases.
    • Crossover Exclusion Criteria:
    • Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.

    Contacts and Locations

    Sponsors and Collaborators Mirati Therapeutics Inc.
    Locations
    • TOI Clinical Research (ICIR) | Cerritos, California, United States, 90703
    • City of Hope - Duarte (Main Campus) | Duarte, California, United States, 91010
    • Providence Medical Group - Santa Rosa | Santa Rosa, California, United States, 95403
    • SCL Health - Saint Joseph Hospital Cancer Center | Lafayette, Colorado, United States, 80026
    • Rocky Mountain Cancer Centers - Lone Tree | Lone Tree, Colorado, United States, 80124
    • Holy Cross Health Fort Lauderdale - Holy Cross Hospital | Fort Lauderdale, Florida, United States, 33308
    • 21st Century Oncology of Jacksonville - North Lee Street | Jacksonville, Florida, United States, 32204
    • Cancer Specialists of North Florida - Southpoint | Jacksonville, Florida, United States, 32256
    • Orlando Health University of Florida Health Cancer Center - Head and Neck Center | Orlando, Florida, United States, 32806
    • USOR - Woodlands Medical Specialists | Pensacola, Florida, United States, 32503
    • University Cancer & Blood Center (UCBC) - Athens | Athens, Georgia, United States, 30607
    • Northwest Georgia Oncology Centers Wellstar - Marietta | Marietta, Georgia, United States, 30060
    • University of Illinois Hospital & Health Sciences System | Chicago, Illinois, United States, 60612
    • University of Chicago | Chicago, Illinois, United States, 60637
    • Illinois Cancer Specialists - Niles | Niles, Illinois, United States, 60714
    • Goshen Center for Cancer Care | Goshen, Indiana, United States, 46526
    • Franciscan Health Cancer Center Indianapolis | Indianapolis, Indiana, United States, 46237
    • Franciscan Health Munster | Munster, Indiana, United States, 46321
    • University of Kansas Medical Center | Westwood, Kansas, United States, 66205
    • Cancer Center of Kansas - Wichita - Heritage Plaza | Wichita, Kansas, United States, 67214
    • Baptist Health Lexington | Lexington, Kentucky, United States, 40503
    • Tulane University | New Orleans, Louisiana, United States, 70112
    • New England Cancer Specialists - Scarborough | Scarborough, Maine, United States, 04074
    • Frederick Health | Frederick, Maryland, United States, 21702
    • Ascension Providence Cancer Center - Southfield | Southfield, Michigan, United States, 48075
    • Central Care Cancer Center - Bolivar | Bolivar, Missouri, United States, 65613
    • St. Vincent Healthcare Cancer Centers of Montana | Billings, Montana, United States, 59101
    • Sisters of Charity of Leavenworth Health St. Marys | Billings, Montana, United States, 59102
    • Astera Cancer Care - East Brunswick | East Brunswick, New Jersey, United States, 08816
    • Holy Name Medical Center | Teaneck, New Jersey, United States, 07666
    • SUNY Upstate Medical University | Syracuse, New York, United States, 13210-2306
    • University Hospitals Cleveland Medical Center | Cleveland, Ohio, United States, 44106
    • Kettering Health Cancer Center - Main Campus | Kettering, Ohio, United States, 45429
    • Oregon Oncology Specialists | Salem, Oregon, United States, 97301
    • Lifespan Cancer Institute - Rhode Island Hospital | Providence, Rhode Island, United States, 02903
    • Prisma Health Cancer Institute - Faris Road | Greenville, South Carolina, United States, 29605
    • Avera Cancer Institute | Sioux Falls, South Dakota, United States, 57105
    • Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North | Arlington, Texas, United States, 76012
    • Texas Oncology - South Austin | Austin, Texas, United States, 78745
    • Local Institution - 012-999 | Irving, Texas, United States, 75063
    • Texas Oncology - Sherman | Sherman, Texas, United States, 75090
    • Utah Cancer Specialists - UCS Cancer Center | Salt Lake City, Utah, United States, 84106
    • UVA Health - University Hospital | Charlottesville, Virginia, United States, 22908-0674
    • NEXT Virginia | Fairfax, Virginia, United States, 22031
    • Flinders Medical Centre | Bedford Park, Australia, 5042
    • Monash Health | Clayton, Australia, 3168
    • Townsville University Hospital | Douglas, Australia, 4814
    • GenesisCare - North Shore | St. Leonards, Australia, 2065
    • The Tweed Hospital | Tweed Heads, Australia, 2485
    • Cancer Care Wollongong | Wollongong, Australia, 2500
    • Princess Alexandra Hospital | Woolloongabba, Australia, 4102
    • Klinikum Klagenfurt Am Worthersee | Klagenfurt Am Woerthersee, Austria, 9020
    • Uniklinikum Salzburg | Salzburg, Austria, 5020
    • Wiener Gesundheitsverbund - Klinik Ottakring | Wien, Austria, 1160
    • Universitair Ziekenhuis Brussel | Brussel, Belgium, 1090
    • Grand Hopital de Charleroi - Notre Dame | Charleroi, Belgium, 6000
    • Universitair Ziekenhuis Antwerpen | Edegem, Belgium, 2650
    • Algemeen Ziekenhuis Maria Middelares | Gent, Belgium, 9000
    • Jessa Ziekenhuis - Campus Virga Jesse | Hasselt, Belgium, 3500
    • Algemeen Ziekenhuis Delta - Campus Rumbeke | Roeselare, Belgium, 8800
    • Algemeen Ziekenhuis Glorieux Ronse | Ronse, Belgium, 9600
    • Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne | Yvoir, Belgium, B-5530
    • Multiscan - Ambulance klinicke onkologie se stacionarem - Horovice | Horovice, Czechia, 268 31
    • Fakultni Nemocnice Olomouc | Olomouc, Czechia, 779 00
    • Fakultni nemocnice Bulovka | Praha 8 - Liben, Czechia, 180 81
    • Hopital Morvan | Brest, France, 29200
    • Hopital Louis Pradel | Bron, France, 69500
    • Centre Hospitalier Universitaire de Caen Normandie | Caen Cedex 09, France, 14033
    • Centre Francois Baclesse | Caen Cedex 5, France, 14076
    • Centre Hospitalier Intercommunal de Creteil | Creteil, France, 94000
    • Centre Georges Francois Leclerc | Dijon cedex, France, 21079
    • LHopital Nord-Ouest (HNO) - Villefranche-sur-Saone | Gleize, France, 69400
    • Hopital Michallon | La Tronche, France, 38700
    • Centre Hospitalier Regional Universitaire de Lille | Lille Cedex, France, 59037
    • Centre Hospitalier Universitaire Dupuytren 1 | Limoges cedex, France, 87042
    • Institut Paoli-Calmettes | Marseille, France, 13009
    • Hopital Nord de Marseille | Marseille, France, 13015
    • Hopital Arnaud de Villeneuve | Montpellier, France, 34090
    • Hopital Emile Muller | Mulhouse, France, 68100
    • Centre Antoine Lacassagne | Nice Cedex 2, France, 06189
    • Centre Hospitalier de Cornouaille - Hopital Laennec | Quimper, France, 29107
    • Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau | Saint Herblain, France, 44805
    • Hopital Civil | Strasbourg cedex, France, 67091
    • Institut de Cancerologie Strasbourg Europe | Strasbourg, France, 67200
    • Hopital Bretonneau | Tours Cedex 9, France, 37044
    • Gustave Roussy | Villejuif, France, 94805
    • Zentralklinik Bad Berka | Bad Berka, Germany, 99437
    • Universitatsklinikum Bonn | Bonn, Germany, 53127
    • Kliniken Essen-Mitte - Evangelische Huyssens-Stiftung | Essen, Germany, 45136
    • Asklepios Fachkliniken Munchen-Gauting | Gauting, Germany, 82131
    • Universitatsklinikum Gieen und Marburg - Gieen | Giessen, Germany, 35392
    • LungenClinic Grosshansdorf | Grohansdorf, Germany, 22927
    • Krankenhaus Martha-Maria Halle-Dolau | Halle, Germany, 06120
    • Universitatsklinikum Jena | Jena, Germany, 07747
    • Klinikum Kassel | Kassel, Germany, 34125
    • Klinikum Koln-Merheim | Koln, Germany, 51109
    • SLK-Kliniken - Fachklinik Lowenstein | Lowenstein, Germany, 74245
    • Universitatsklinikum Schleswig-Holstein - Campus Lubeck | Lubeck, Germany, 23538
    • Munchen Klinik Bogenhausen | Munchen, Germany, 81925
    • Sana Klinikum Offenbach | Offenbach, Germany, 63069
    • Pius-Hospital Oldenburg | Oldenburg, Germany, 26121
    • Henry Dunant Hospital Center | Athens, Greece, 11526
    • General Hospital for Thoracic Diseases Sotiria | Athens, Greece, 11527
    • University General Hospital of Heraklion (PAGNI) | Heraklion, Greece, 71110
    • University General Hospital of Larissa | Larissa, Greece, 41110
    • "General Oncology Hospital of Kifisias "Agioi Anargyroi"" | Nea Kifisia, Greece, 145 64
    • Metropolitan Hospital | Peiraias, Greece, 185 47
    • BioClinic Thessaloniki | Thessaloniki, Greece, 54622
    • Interbalkan Medical Center of Thessaloniki | Thessaloniki, Greece, 57001
    • General Hospital of Thessaloniki George Papanikolaou | Thessaloniki, Greece, 57010
    • Anassa General Clinic | Volos, Greece, 38333
    • Humanity & Health Clinical Trial Centre | Central, Hong Kong, Array
    • Prince of Wales Hospital - Hong Kong | Hong Kong, Hong Kong, Array
    • Hong Kong United Oncology Centre | Kowloon, Hong Kong, Array
    • Semmelweis Egyetem - Pulmonologiai Klinika | Budapest, Hungary, 1083
    • Orszagos Koranyi Pulmonologiai Intezet | Budapest, Hungary, 1121
    • Orszagos Onkologiai Intezet | Budapest, Hungary, 1122
    • Matrai Gyogyintezet | Gyongyos, Hungary, 3200
    • Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaz | Gyula, Hungary, 5700
    • Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz | Szekesfehervar, Hungary, 8000
    • Reformatus Pulmonologiai Centrum | Torokbalint, Hungary, 2045
    • The Meath Foundation | Tallaght, Dublin, Ireland, D24 NR04
    • St. Vincents University Hospital | Dublin, Ireland, 4
    • Beaumont Hospital - Dublin | Dublin, Ireland, 9
    • St. Jamess Hospital | Dublin, Ireland, D08 NHY1
    • University Hospital Galway | Galway, Ireland, H91 YR71
    • University Hospital Limerick | Limerick, Ireland, V94 F858
    • Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo - Alessandria | Alessandria, Italy, 15121
    • Azienda Ospedaliera San Giuseppe Moscati - Avellino | Avellino, Italy, 83100
    • Centro di Riferimento Oncologico | Aviano, Italy, 33081
    • Istituto Tumori Bari Giovanni Paolo II - IRCCS | Bari, Italy, 70124
    • Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia | Brescia, Italy, 25123
    • Istituto di Candiolo - Fondazione del Piemonte per lOncologia | Candiolo, Italy, 10060
    • Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi | Catania, Italy, 95122
    • Azienda Ospedaliero - Universitaria - Policlinico - Vittorio Emanuele | Catania, Italy, 95123
    • Azienda Ospedaliero - Universitaria Careggi | Firenze, Italy, 50134
    • ASL 3 Genovese - Ospedale Villa Scassi - Sampierdarena | Genova, Italy, 16100
    • Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Policlinico San Martino | Genova, Italy, 16132
    • Ospedale Vito Fazzi Lecce | Lecce, Italy, 73100
    • "Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST" | Meldola, Italy, 47014
    • Fondazione IRCCS - Istituto Nazionale dei Tumori | Milano, Italy, 20133
    • Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele | Milan, Italy, 20132
    • Istituto Europeo di Oncologia | Milan, Italy, 20141
    • Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli | Napoli, Italy, 80131
    • Istituto Nazionale Tumori IRCCS Fondazione G. Pascale | Napoli, Italy, 80131
    • Azienda Ospedaliero-Universitaria Maggiore della Carita di Novara | Novara, Italy, 28100
    • Azienda Ospedaliero-Universitaria di Parma | Parma, Italy, 43126
    • Azienda Ospedaliera di Perugia - Santa Maria della Misericordia | Perugia, Italy, 06132
    • Azienda Ospedaliera Ospedali Riuniti Marche Nord | Pesaro, Italy, 61122
    • Ospedale Santa Maria delle Croci di Ravenna | Ravenna, Italy, 48121
    • Azienda Ospedaliera Universitaria Integrata Verona | Verona, Italy, 37126
    • Pusan National University Hospital | Busan-si, Korea, Republic of, 49241
    • Inje University Haeundae Paik Hospital | Busan, Korea, Republic of, 48108
    • Kosin University Gospel Hospital | Busan, Korea, Republic of, 602702
    • Chungbuk National University Hospital | Cheongju-si, Korea, Republic of, 28644
    • Kyungpook National University Chilgok Hospital | Daegu, Korea, Republic of, 41404
    • Keimyung University Dongsan Hospital | Daegu, Korea, Republic of, 42601
    • Gachon University Gil Medical Center | Incheon, Korea, Republic of, 21565
    • Inha University Hospital | Jung-Gu, Korea, Republic of, 400-712
    • Cha Bundang Medical Center | Seongnam-si, Korea, Republic of, 13496
    • Seoul National University Bundang Hospital | Seongnam-si, Korea, Republic of, 13620
    • Korea University Anam Hospital | Seoul, Korea, Republic of, 02841
    • Severance Hospital - Yonsei Cancer Center | Seoul, Korea, Republic of, 03722
    • Konkuk University Medical Center | Seoul, Korea, Republic of, 05080
    • Asan Medical Center | Seoul, Korea, Republic of, 05505
    • The Catholic University of Korea - Seoul St. Marys Hospital | Seoul, Korea, Republic of, 06591
    • Catholic University of Korea Saint Vincents Hospital | Suwon-Si, Korea, Republic of, 16247
    • Ajou University Hospital | Suwon-si, Korea, Republic of, 16499
    • Amsterdam Universitair Medische Centra (UMC) - Locatie Vrije Universiteit Medisch Centrum | Amsterdam, Netherlands, 1081 HV
    • Hagaziekenhuis Van Den Haag - Leyweg | Den Haag, Netherlands, 2545 AA
    • Maastricht Universitair Medisch Centrum | Maastricht, Netherlands, 6229 HX
    • Radboud Universitair Medisch Centrum | Nijmegen, Netherlands, 6525 GA
    • St. Antonius Ziekenhuis - Ziekenhuis Utrecht | Utrecht, Netherlands, 3543 AZ
    • Universitair Medisch Centrum Utrecht | Utrecht, Netherlands, 3584 CX
    • Instytut MSF | Lodz, Poland, 90-302
    • MS Pnuemed - Janusz Milanowski, Katarzyna Szmygin-Milanowska Spolka Jawna | Lublin, Poland, 20-064
    • Specjalistyczna Praktyka Lekarska Slawomir Mandziuk | Lublin, Poland, 20-093
    • Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy | Otwock, Poland, 05-400
    • Mruk-Med I Sp. z o.o. | Rzeszow, Poland, 35-922
    • Pratia Poznan | Skorzewo, Poland, 60-185
    • Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu | Torun, Poland, 87-100
    • Wojskowy Instytut Medyczny | Warsaw, Poland, 04-349
    • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy | Warszawa, Poland, 02-781
    • Unidade Local de Saude de Almada-Seixal, E. P. E (Hospital Garcia de Orta) | Almada, Portugal, 2805-267
    • Unidade Local de Saude de Braga, E. P. E (Hospital de Braga) | Braga, Portugal, 4710-243
    • Instituto Portugues de Oncologia de Coimbra Francisco Gentil | Coimbra, Portugal, 3000-075
    • Unidade Local de Saude de Coimbra | Coimbra, Portugal, 3000-075
    • Unidade Local de Saude do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimaraes) | Guimaraes, Portugal, 4835-044
    • Instituto Portugues De Oncologia De Lisboa Francisco Gentil | Lisbon, Portugal, 1099-023
    • The Champalimaud Centre for the Unknown | Lisbon, Portugal, 1400-038
    • Hospital CUF Descobertas | Lisbon, Portugal, 1998-018
    • Unidade Local de Saude de Loures-Odivelas, EPE (Hospital Beatriz Angelo) | Loures, Portugal, 2674-514
    • Hospital CUF Porto | Porto, Portugal, 14341
    • Unidade Local de Saude de Santo Antonio, E. P. E - Hospital Geral de Santo Antonio | Porto, Portugal, 4099-001
    • Instituto Portugues de Oncologia do Porto Francisco Gentil | Porto, Portugal, 4200-072
    • Unidade Local de Saude de Entre Douro e Vouga, E. P. E | Santa Maria Da Feira, Portugal, 4520-211
    • Unidade Local de Saude da Arrabida, E. P. E (Centro Hospitalar de Setubal) | Setubal, Portugal, 2910-443
    • Unidade Local de Saude de Gaia/Espinho, E. P. E | Vila Nova de Gaia, Portugal, 4434-502
    • Puerto Rico Medical Research Center | San Juan, Puerto Rico, 00919
    • Fundacion de Investigacion de Diego Clinical Research | San Juan, Puerto Rico, 00927
    • PanOncology Trials - Rio Piedras Medical Center | San Juan, Puerto Rico, 00935
    • Spitalul Jude�ean de Urgen�a dr. Constantin Opri� Baia Mare | Baia Mare, Romania, 430031
    • SC Policlinica de Diagnostic Rapid SA | Brașov, Romania, 500152
    • Institutul Oncologic Bucuresti - Prof. Dr. Alexandru Trestioreanu | Bucharest, Romania, 022328
    • Centrul Oncologic Sanador | București, Romania, 010991
    • Institutul Oncologic Prof. Dr. Ion Chiricuta | Cluj-Napoca, Romania, 400015
    • Medisprof | Cluj-Napoca, Romania, 400641
    • Oncolab Craiova | Craiova, Romania, 200385
    • Centrul de Oncologie Sf Nectarie | Craiova, Romania, 200746
    • Centrul de Oncologie Euroclinic | Iasi, Romania, 700106
    • Ovidius Clinical Hospital | Ovidiu, Romania, 905900
    • SC OncoMed SRL | Timisoara, Romania, 300239
    • Oncocenter - Oncologie Clinica | Timișoara, Romania, 300166
    • Evimed Oncology Clinic | Chelyabinsk, Russian Federation, 454048
    • "Budgetary Healthcare Institution of the Udmurt Republic "Republican Clinical Oncological Dispensary n.a. Sergey Grigoryevich Pr | Izhevsk, Russian Federation, 426067
    • "Regional Budgetary Healthcare Institution "G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center" of the Healthcare C | Kislino Village, Russian Federation, 305524
    • VitaMed - Moscow | Moscow, Russian Federation, 121309
    • University Headache Clinic | Moscow, Russian Federation, 121467
    • State Budgetary Healthcare Institution of the Nizhny Novgorod Region Clinical Diagnostic Center | Nizhniy Novgorod, Russian Federation, 603006
    • "Limited Liability Company Medical Sanitary Unit "Clinicist-Clinic Pretor"" | Novosibirsk, Russian Federation, 630099
    • "Budgetary Healthcare Institution of Omsk region "Clinical Oncologic Dispensary"" | Omsk, Russian Federation, 644013
    • EuroCityClinic LLC | Saint Petersburg, Russian Federation, 197022
    • Saint Petersburg Clinical Scientific & Practical Center for Specialized Types of Medical Care (Oncology) | Saint Petersburg, Russian Federation, 197758
    • "Federal State Budgetary Institution "Influenza Research Institute named after N.N. A.A. Smorodintsev" of the Ministry of Health | Saint-Petersburg, Russian Federation, 197376
    • National Cancer Centre Singapore | Singapore, Singapore, 168583
    • Raffles Hospital | Singapore, Singapore, 188770
    • Icon Cancer Centre Farrer Park | Singapore, Singapore, 217562
    • Oncocare Cancer Centre | Singapore, Singapore, 258499
    • Parkway Cancer Centre - Gleneagles Hospital | Singapore, Singapore, 258500
    • Complejo Hospitalario Universitario A Coruna | A Coruna, Spain, 15006
    • Hospital General Universitario Dr. Balmis | Alicante, Spain, 3010
    • Hospital Germans Trias i Pujol | Badalona, Spain, 08916
    • Hospital Universitario Cruces | Barakaldo, Spain, 48903
    • Hospital del Mar - Parc de Salut Mar | Barcelona, Spain, 08003
    • Hospital Universitari Dexeus | Barcelona, Spain, 08028
    • Hospital Universitari Vall dHebron | Barcelona, Spain, 08035
    • Hospital Clinic de Barcelona | Barcelona, Spain, 08036
    • Hospital Universitario Reina Sofia | Cordoba, Spain, 14004
    • Institut Catala dOncologia Girona (ICO Girona) | Girona, Spain, 17007
    • Hospital Universitario Virgen de las Nieves | Granada, Spain, 18014
    • Complejo Hospitalario Universitario Insular Materno Infantil | Las Palmas de Gran Canaria, Spain, 35016
    • Hospital de Leon | Leon, Spain, 24008
    • Hospital Universitario Lucus Augusti | Lugo, Spain, 27003
    • Hospital Beata Maria Ana | Madrid, Spain, 28007
    • Clinica Universidad de Navarra - Madrid | Madrid, Spain, 28027
    • Hospital Universitario Ramon y Cajal | Madrid, Spain, 28034
    • Hospital Clinico San Carlos | Madrid, Spain, 28040
    • Hospital Universitario Fundacion Jimenez Diaz | Madrid, Spain, 28040
    • Hospital Universitario 12 de Octubre | Madrid, Spain, 28041
    • Hospital Universitario Puerta de Hierro - Majadahonda | Majadahonda, Spain, 28222
    • Hospital Regional Universitario de Malaga - Hospital Civil | Malaga, Spain, 29009
    • Hospital Universitario Son Espases | Palma de Mallorca, Spain, 07120
    • Hospital Universitario Marques de Valdecilla | Santander, Spain, 39008
    • Consorci Hospital General Universitari de Valencia | Valencia, Spain, 46014
    • Hospital Universitari i Politecnic La Fe | Valencia, Spain, 46026
    • Hospital Clinico Universitario Lozano Blesa | Zaragoza, Spain, 50009
    • Universitatsspital Basel | Basel, Switzerland, 4031
    • Kantonsspital Winterthur | Winterthur, Switzerland, 8401
    • University Hospital Birmingham NHS Foundation Trust | Birmingham, United Kingdom, B15 2WB
    • NHS Lothian | Edinburgh, United Kingdom, EH4 2XU
    • NHS Greater Glasgow and Clyde | Glasgow, United Kingdom, G12 0XH
    • University Hospitals of Leicester NHS Trust | Leicester, United Kingdom, LE1 5WW
    • The Christie NHS Foundation Trust | Manchester, United Kingdom, M20 4BX
    Investigators

      More Information

      Additional Information

      Additional Relevant MeSH Terms

      • Lung Neoplasms
      • Carcinoma, Non-Small-Cell Lung
      • Respiratory Tract Neoplasms
      • Thoracic Neoplasms
      • Neoplasms by Site
      • Neoplasms
      • Lung Diseases
      • Respiratory Tract Diseases
      • Carcinoma, Bronchogenic
      • Bronchial Neoplasms