A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Guselkumab Subcutaneous Induction Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

ClinicalTrials.gov processed this data on December 5, 2024. Link to the current ClinicalTrials.gov record.

Recruitment Status

ACTIVE, NOT RECRUITING (See Contacts and Locations)
Verified December 2024 by Janssen Research & Development, LLC

Sponsor

Janssen Research & Development, LLC

Information Provided by (Responsible Party)

Janssen Research & Development, LLC

Clinicaltrials.gov Identifier

NCT05528510
Other Study ID Numbers: CR109228
First Submitted: August 19, 2022
First Posted: September 6, 2022
Last Update Posted: December 6, 2024
Last Verified: December 2024
History of Changes

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Study Description

Not Provided
Condition or Disease Intervention/Treatment
  • Colitis, Ulcerative
  • Drug: Guselkumab Dose 1
  • Drug: Guselkumab Dose 2
  • Drug: Guselkumab Dose 3
  • Other: Placebo

Study Design

Study TypeInterventional
Actual Enrollment418 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingDouble
Primary PurposeTreatment
Official TitleA Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Guselkumab Subcutaneous Induction Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
Study Start DateSeptember 13, 2022
Actual Primary Completion DateApril 2, 2024
Anticipated Study Completion DateOctober 6, 2028

Groups and Cohorts

Group/ CohortIntervention/ Treatment
  • Group 1: Guselkumab
    • Participants will receive guselkumab (Dose 1) subcutaneous (SC) injection followed by guselkumab (Dose 2) SC injection.
  • Drug: Guselkumab Dose 1
    • Guselkumab (Dose 1) will be administered as SC injection.
  • Drug: Guselkumab Dose 2
    • Group 2: Guselkumab
      • Participants will receive guselkumab (Dose 1) SC injection followed by guselkumab (Dose 3) SC injection.
    • Drug: Guselkumab Dose 1
      • Guselkumab (Dose 1) will be administered as SC injection.
    • Drug: Guselkumab Dose 3
      • Group 3: Placebo
        • Participants will receive matching placebo SC injection.
      • Other: Placebo

        Outcome Measures

        Primary Outcome Measures

        1. Clinical Remission [Week 12]
          Clinical remission per modified Mayo score.

        Secondary Outcome Measures

        1. Symptomatic Remission [Weeks 12 and 24]
          Symptomatic remission per Mayo score is defined as a stool frequency subscore of 0 (normal number of stools) or 1 (1 to 2 stools more than normal) and a rectal bleeding subscore of 0 (no blood seen).
        2. Endoscopic Improvement [Weeks 12 and 24]
          Endoscopic improvement per Mayo endoscopy subscore.
        3. Clinical Response [Weeks 12 and 24]
          Clinical response per modified Mayo score.
        4. Clinical Remission [Week 24]
          Clinical remission per modified Mayo score.
        5. Histologic-Endoscopic Mucosal Improvement [Week 12]
          Histologic-endoscopic mucosal improvement is defined as a combination of histologic improvement according to the Geboes grading system and endoscopic improvement (Mayo endoscopy subscore of 0 or 1 without friability).
        6. Percentage of Participants with Adverse Events (AEs), Serious Adverse Events (SAEs) and AEs Leading to Discontinuation of Study Intervention [Up to Week 268]
          Percentage of participants with AEs, SAEs and AEs leading to discontinuation of study intervention will be reported. An AE is any untoward medical occurrence in a participant participating in a clinical study that does not necessarily have a causal relationship with the pharmaceutical/biological agent under study. An SAE is an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly.

        Eligibility Criteria

        Ages Eligible for Study 18 Years and Older (Adult, Older Adult)
        Sexes Eligible for Study All
        Accepts Healthy Volunteers No
        Inclusion Criteria
        • Signed informed consent form
        • 18 years of age or older
        • Documented diagnosis of ulcerative colitis (UC) at least 12 weeks prior to screening
        • Moderately to severely active UC as per the modified Mayo score
        • Demonstrated inadequate response to or intolerance of conventional therapy and/or advanced therapy as defined in the protocol
        Exclusion Criteria
        • Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, or Crohn's disease
        • Surgery within 8 weeks before screening or planned surgery during the study that may confound the evaluation of benefit from study intervention
        • Receiving prohibited medications and treatments
        • UC limited to the rectum only
        • Active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) corona virus disease (COVID-19) infection

        Contacts and Locations

        Sponsors and Collaborators Janssen Research & Development, LLC
        Locations
        • Research Solutions of Arizona | Litchfield Park, Arizona, United States, 85340
        • Om Research LLC | Apple Valley, California, United States, 92307
        • Om Research LLC | Lancaster, California, United States, 93534
        • Medical Associates Research Group, Inc. | San Diego, California, United States, 92123
        • Peak Gastroenterology Associates | Colorado Springs, Colorado, United States, 80907
        • Gastro Florida | Clearwater, Florida, United States, 33762
        • I.H.S. Health. LLC | Kissimmee, Florida, United States, 34741
        • Columbus Clinical Services LLC | Miami, Florida, United States, 33125
        • Vista Health Research, LLC | Miami, Florida, United States, 33176
        • Orlando Health | Orlando, Florida, United States, 32806
        • Theia Clincial Research, LLC | Temple Terrace, Florida, United States, 34209
        • Digestive Healthcare of Georgia, P.C | Atlanta, Georgia, United States, 30309
        • Atlanta Gastroenterology Associates | Atlanta, Georgia, United States, 30342
        • Gastroenterology Associates of Central GA | Macon, Georgia, United States, 31201
        • Cotton O'Neil Digestive Health Center | Topeka, Kansas, United States, 66606
        • Clinical Research Institute of Michigan, LLC | Chesterfield, Michigan, United States, 48047
        • Detroit Clinical Research Center | Farmington Hills, Michigan, United States, 48334
        • Smart Medical Research | Hollis, New York, United States, 11423
        • University of North Carolina | Chapel Hill, North Carolina, United States, 27599-7080
        • Peters Medical Research | High Point, North Carolina, United States, 27260
        • Dayton Gastroenterology, Inc | Dayton, Ohio, United States, 45415
        • Gastro Intestinal Research Institute of Northern Ohio LLC | Westlake, Ohio, United States, 44145
        • Allegheny General Hospital of Research | Pittsburgh, Pennsylvania, United States, 15224
        • Frontier Clinical Research | Uniontown, Pennsylvania, United States, 15401
        • Gastroenterology Associates of Orangeburg, SC | Orangeburg, South Carolina, United States, 29118
        • Southern Star Research Institute, LLC | San Antonio, Texas, United States, 78229
        • UT Health Science Center at San Antonio | San Antonio, Texas, United States, 78229
        • Tyler Research Institute, LLC | Tyler, Texas, United States, 75701
        • Victoria Gastroenterology | Victoria, Texas, United States, 77407
        • Care Access Research, Ogden | Ogden, Utah, United States, 84403
        • Gastroenterology Associates | Salt Lake City, Utah, United States, 84124
        • Gastroenterology Associates of Tidewater | Chesapeake, Virginia, United States, 23320
        • Cer Instituto Medico | Buenos Aires, Argentina, B1878DVB
        • Hospital General de Agudos José Maria Ramos Mejía | Buenos Aires, Argentina, C1221ADC
        • Clinica Adventista Belgrano | Ciudad De Buenos Aires, Argentina, C1430EGF
        • Sanatorio Duarte Quiroz | Cordoba, Argentina, X5002AOQ
        • Hospital Privado Universitario De Cordoba | Cordoba, Argentina, X5016KEH
        • Hospital Italiano de La Plata | La Plata, Argentina, B1900AXI
        • Centro de Investigaciones Medicas Mar Del Plata | Mar Del Plata, Argentina, B7600FYK
        • Hospital Provincial del Centenario | Rosario, Argentina, S2000KDS
        • Royal Adelaide Hospital | Adelaide, Australia, 5000
        • Royal Prince Alfred Hospital | Camperdown, Australia, 2050
        • Monash Health | Clayton, Australia, 3168
        • Royal Brisbane and Women's Hospital | Herston, Australia, 4029
        • Fiona Stanley Hospital | Murdoch, Australia, 6150
        • Royal Melbourne Hospital | Parkville, Australia, 3050
        • IBD Clinical Trials Mater Research | South Brisbane, Australia, 4101
        • The Queen Elizabeth Hospital | Woodville South, Australia, 5011
        • Princess Alexandra Hospital | Woolloongabba, Australia, 4102
        • Onze -Lieve-Vrouwziekenhuis | Aalst, Belgium, 9300
        • CHU Saint-Pierre | Brussels, Belgium, 1000
        • AZ Delta | Roeselare, Belgium, 8800
        • Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu) | Botucatu, Brazil, 18618-687
        • L2IP Instituto de Pesquisas Clinicas | Brasilia, Brazil, 70200-730
        • Sociedade Campineira de Educacao e Instrucao Hospital e Maternidade Celso Pierro | Campinas, Brazil, 13060-904
        • CDC - Centro Digestivo de Curitiba | Curitiba, Brazil, 80430-180
        • CECIP Jau - Centro de Estudos Clínicos do Interior Paulista Ltda | Jau, Brazil, 17201-130
        • Galileo Pesquisa Clinica | Juiz de Fora, Brazil, 36033 318
        • Hospital das Clinicas de Porto Alegre | Porto Alegre, Brazil, 90035-903
        • NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul | Porto Alegre, Brazil, 90430-001
        • CLIAGEN - Clinica de Atencao em Gastroenterologia Especializada e Nutricao | Salvador, Brazil, 41500-300
        • Pesquisare Saude | Santo Andre, Brazil, 09080-110
        • BR TRIALS Ensaios Clinicos e Consultoria Ltda | Sao Paulo, Brazil, 01236030
        • Instituto D Or de Pesquisa e Ensino IDOR | Sao Paulo, Brazil, 01401-002
        • Kaiser Hospta | São José Do Rio Preto, Brazil, 15015-110
        • INTEGRAL Pesquisa e Ensino | Votuporanga, Brazil, 15501-405
        • Medical centre Asklepion | Sofia, Bulgaria, 1606
        • DCC Convex EOOD | Sofia, Bulgaria, 1680
        • Medical Center Leo Clinic EOOD | Targovishte, Bulgaria, 7700
        • Fraser Clinical Trials Inc. | New Westminster, British Columbia, Canada, V3L 3W4
        • Barrie GI Associates | Barrie, Ontario, Canada, L4M 7G1
        • Royal University Hospital | Saskatoon, Saskatchewan, Canada, S7N 0W8
        • China Japan Friendship Hospital | Beijing, China, 100029
        • Peking University Third Hospital | Beijing, China, 100191
        • West China Hospital Sichuan University | Chengdu, China, 610041
        • Chongqing General Hospital | Chongqing, China, 400014
        • First Affiliated Hospital of Gannan Medical University | Ganzhou, China, 341000
        • The Second Affiliated Hospital of Guangzhou Medical University | Guangzhou, China, 510260
        • ZhuJiang Hospital of Southern Medical University | Guangzhou, China, 510280
        • The First Affiliated Hospital Zhejiang University College of Medicine | Hangzhou, China, 310003
        • The Second Affiliated Hospital of Zhejiang University College of Medicine | Hangzhou, China, 310009
        • The First Affiliated Hospital of Anhui Medical University | Hefei, China, 230022
        • Jinhua municipal central hospital | Jinhua, China, 321009
        • Lanzhou University Second Hospital | Lan Zhou, China, 730030
        • The first affiliated hospital of Henan University of science and technology | Luoyang, China, 471003
        • Nanjing Drum Tower Hospital | Nanjing, China, 210008
        • Zhongda Hospital Southeast University | Nanjing, China, 210009
        • Ruijin Hospital Shanghai Jiao Tong University | Shanghai, China, 200025
        • Shanghai East Hospital | Shanghai, China, 200123
        • Shengjing Hospital Of China Medical University | Shenyang, China, 110004
        • Shenzhen Hospital of Southern Medical University | Shenzhen, China, 518101
        • The Second Hospital of Hebei Medical University | Shi Jia Zhuang Shi, China, 050004
        • Taihe Hospital | Shiyan, China, 442000
        • Renmin Hospital of Wuhan University | Wuhan, China, 430060
        • Wuxi People s Hospital | Wuxi, China, 214023
        • General Hospital of Ningxia Medical Hospital | Yinchuan, China, 750011
        • The Second Affiliated Hospital of Zhengzhou University | Zhengzhou, China, 450014
        • Nemocnice Ceske Budejovice a s | Ceske Budejovice, Czechia, 37001
        • Gastroenterologie, s.r.o., Hradec Kralove | Hradec Kralova, Czechia, 500 02
        • Artroscan s r o | Ostrava, Czechia, 722 00
        • AXON Clinical s.r.o. | Prague, Czechia, 15000
        • Synexus Czech s.r.o. | Praha 2, Czechia, 120 00
        • ISCARE a.s. | Praha 9, Czechia, 190 00
        • CHRU Besancon Hopital Jean Minjoz | Besancon Cedex, France, 25030
        • Hopital de Bicetre | Le Kremlin Bicêtre, France, 94270
        • CHRU Montpellier - Hopital Saint-Eloi | Montpellier, France, 34295 Cedex 5
        • Clinique Ambroise Pare | Neuilly-sur-Seine, France, 92200
        • CHU de Nice Hopital de l Archet | Nice, France, 06202
        • Polyclinique Du Grand Sud | Nîmes, France, 30932
        • CHU de Bordeaux - Hospital Haut-Leveque | Pessac, France, 33604
        • Hospices Civils de Lyon HCL | Pierre Benite, France, 69495
        • CHU de Reims | Reims Cedex, France, 51092
        • CHU Saint Etienne Hopital Nord | Saint Priest en Jarez, France, 42270
        • Hopital d'Instruction des Armees BEGIN | Saint-Mande, France, 94160
        • CHU Rangueil | Toulouse, France, 31059
        • CHU Nancy Brabois | Vandoeuvre Les nancy, France, 54500
        • Medizinisches Versorgungszentrum (MVZ) Dachau | Dachau, Germany, 85221
        • MVZ Sanaklinikum Duisburg | Duisburg, Germany, 47055
        • Medizinische Hochschule Hannover | Hannover, Germany, 30625
        • Praxisgemeinschaft Jerichow | Jerichow, Germany, 39319
        • Staedtisches Klinikum Lueneburg | Lueneburg, Germany, 21339
        • Magyar Honvedseg Egeszsegugyi Kozpont | Budapest, Hungary, 1062
        • Semmelweis Egyetem | Budapest, Hungary, 1082
        • Semmelweis Egyetem AOK | Budapest, Hungary, 1088
        • Vasutegeszsegugyi Nonprofit Kozhasznu Kft Debreceni Kozpont | Debrecen, Hungary, 4025
        • Fortis Memorial Research Institute | Gurugram, India, 122002
        • Asian Institute Of Gastroenterology | Hyderabad, India, 500032
        • Kasturba Medical College Hospital | Manipal, India, 576104
        • P D Hinduja National Hospital and Medical Research Center | Mumbai, India, 400016
        • SIDS (Surat Institute of Digestive Sciences) Hospital and Research Centre | Surat, India, 395002
        • Ha'Emek Medical Center | Afula, Israel, 1834111
        • Bnai Zion Medical Center | Haifa, Israel, 3339419
        • Wolfson Medical Center | Holon, Israel, 5822012
        • Shaare Zedek Medical Center - Jerusalem, ISRAEL | Jerusalem, Israel, 91031
        • Lev Talpiot Clinic | Jerusalem, Israel, 93624
        • Galilee Medical Center | Nahariya, Israel, 2210001
        • Chaim Sheba Medical Center | Ramat Gan, Israel, 5262000
        • Tokyo Medical and Dental University Hospital | Bunkyo-ku, Japan, 113-8510
        • Ginza central clinic | Chuo-ku, Japan, 1040061
        • Sai Gastroenterology Proctology | Fujiidera-shi, Japan, 583-0027
        • Fukuoka University Hospital | Fukuoka, Japan, 814 0180
        • Fukushima Medical University Hospital | Fukushima, Japan, 960-1295
        • Hachinohe City Hospital | Hachinohe, Japan, 031-8555
        • Tokai University Hachioji Hospital | Hachioji, Japan, 192-0032
        • Matsuda Hospital | Hamamatsu shi, Japan, 432 8061
        • National Hospital Organization Mito Medical Center | Higashiibaraki-gun, Japan, 311-3193
        • Kagoshima University Hospital | Kagoshima, Japan, 890-8520
        • Kagoshima IBD Gastroenterology Clinic | Kagoshima, Japan, 892-0843
        • National Hospital Organization Kanazawa Medical Center | Kanazawa, Japan, 920-8650
        • Tsujinaka Hospital Kashiwanoha | Kashiwa, Japan, 277-0871
        • Kyushu Rosai Hospital | Kitakyushu, Japan, 800-0296
        • Kumagaya General Hospital | Kumagaya-shi, Japan, 360-8567
        • National Hospital Organization Kure Medical Center and Chugoku Cancer Center | Kure, Japan, 737-0023
        • Tokushukai Chiba-Nishi General Hospital | Matsudo, Japan, 270-2251
        • National Hospital Organization Matsumoto Medical Center | Matsumoto, Japan, 399-8701
        • Yokoyama IBD Clinic | Nagoya, Japan, 460-0022
        • Oita Red Cross Hospital | Oita, Japan, 870-0033
        • Ishida Clinic of IBD and Gastroenterology | Oita, Japan, 870-0823
        • Okayama Saiseikai General Hospital | Okayama, Japan, 700-0013
        • Kindai University Hospital | Osaka-Sayama, Japan, 589-8511
        • Kinshukai Infusion Clinic | Osaka, Japan, 530-0011
        • Japanese Red Cross Osaka Hospital | Osaka, Japan, 543-8555
        • Dokkyo Medical University Hospital | Shimotsuga Gun, Japan, 321 0293
        • Tokyo Metropolitan Bokutoh Hospital | Sumida ku, Japan, 130 8575
        • National Hospital Organization Shizuoka Medical Center | Sunto-gun, Japan, 411-8611
        • Center Hospital of the National Center for Global Health and Medicine | Tokyo, Japan, 162-8655
        • Juntendo University Hospital Urayasu | Urayasu, Japan, 279-0021
        • Kanke Gastrointestinal Clinic | Utsunomiya-shi, Japan, 320-0003
        • Yokohama City University Medical Center | Yokohama, Japan, 232 0024
        • The Speciality Hospital (TSH) / Advanced Clinical Center | Amman, Jordan, 11194
        • Jordan University Hospital | Amman, Jordan, 11942
        • Irbid Specialty Hospital | Aydoun, Jordan, 21166
        • King Abdullah University Hospital | Irbid, Jordan, 22110
        • Inje University Haeundae Paik Hospital | Busan, Korea, Republic of, 48108
        • Yeungnam University Medical Center | Daegu, Korea, Republic of, 42415
        • National Cancer Center | Goyang-Si, Korea, Republic of, 10408
        • Chosun university hospital | Gwangju, Korea, Republic of, 61453
        • Korea University Ansan Hospital | Gyeonggi-do, Korea, Republic of, 15355
        • Kangbuk Samsung Hospital | Seoul, Korea, Republic of, 03181
        • Severance Hospital Yonsei University Health System | Seoul, Korea, Republic of, 03722
        • Samsung Medical Center | Seoul, Korea, Republic of, 06351
        • Chung-Ang University Hospital | Seoul, Korea, Republic of, 06973
        • Kyung Hee University Hospital | Seoul, Korea, Republic of, 130 050
        • The Catholic university of Korea ST Vincent Hospital | Suwon si, Korea, Republic of, 16247
        • Hospital Selayang | Batu Caves, Malaysia, 68100
        • Hospital Pulau Pinang | George Town, Malaysia, 10990
        • Hospital Sultanah Aminah | Johor Bahru, Malaysia, 80100
        • University Malaya Medical Centre | Kuala Lumpur, Malaysia, 59100
        • Hospital Umum Sarawak | Kuching, Malaysia, 93586
        • Hospital Tuanku Jaafar | Seremban, Malaysia, 70300
        • SCIENTIA Investigacion Clinica SC | Chihuahua, Mexico, 31207
        • Centro de Investigacion Clinica Acelerada S.C | Ciudad de Mexico, Mexico, 07369
        • Hospital Médica Sur Tlalpan | Ciudad de Mexico, Mexico, 14050
        • Clinica de Investigacion en Reumatologia y Obesidad | Guadalajara, Mexico, 44650
        • Medical Care & Research SA de CV | Merida, Mexico, 97070
        • Clinicos Asociados BOCM, SC | Mexico City, Mexico, 03300
        • Centro Regiomontano de Estudios Clínicos Roma S.C. | Monterrey, Mexico, 64610
        • Fundacion Santos Y De La Garza Evia IBP | Monterrey, Mexico, 64710
        • Clinical Research Institute Saltillo S.A. de C.V. | Saltillo, Mexico, 25020
        • Oncare | San Pedro Garza Garcia, Mexico, 66220
        • Hutt Hospital | Boulcott, New Zealand, 5010
        • Christchurch Hospital | Christchurch, New Zealand, 8011
        • Dunedin Hospital | Dunedin, New Zealand, 9016
        • Auckland City Hospital | Grafton, New Zealand, 1023
        • Waikato Hospital | Hamilton, New Zealand, 3204
        • Gastromed Kralisz Romatowski Stachurska Sp. j. | Bialystok, Poland, 15-322
        • Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy | Bydgoszcz, Poland, 85-168
        • Centrum Medyczne Lukamed | Chojnice, Poland, 89-600
        • Centrum Medyczne Clw-Med Aneta Cichomska i Joanna Luka-Wendrowska sp.j. | Grudziadz, Poland, 86-300
        • Centrum Medyczne Plejady | Krakow, Poland, 30-363
        • Centrum Medyczne Promed | Krakow, Poland, 31-513
        • Zespol Poradni Specjalistycznych REUMED Filia nr 2 | Lublin, Poland, 20-582
        • EMC Instytut Medyczny SA PL CERTUS | Poznan, Poland, 60 309
        • Centrum Medyczne Medyk | Rzeszow, Poland, 35-326
        • Twoja Przychodnia - Szczecinskie Centrum Medyczne | Szczecin, Poland, 71-434
        • GASTROMED Sp. z o.o. | Torun, Poland, 87-100
        • Gabinety Lekarskie Bodyclinic | Warszawa, Poland, 03-712
        • Medical Network Spolka z o.o. WIP Warsaw IBD Point Profesor Kierkus | Warszawa, Poland, 04 501
        • Melita Medical Sp. z o.o. | Wroclaw, Poland, 50-449
        • Przychodnia Vistamed | Wroclaw, Poland, 53-149
        • Pro Life Medica Sp z o o ETG Zamosc | Zamosc, Poland, 22 400
        • FNsP F.D.R. Banska Bystrica | Banska Bystrica, Slovakia, 975 17
        • Cliniq s.r.o. | Bratislava, Slovakia, 811 09
        • ENDOMED s.r.o | Kosice, Slovakia, 040 13
        • KM Management spol. s r.o. | Nitra, Slovakia, 949 01
        • Hosp. Univ. Germans Trias I Pujol | Badalona, Spain, 08916
        • Hosp. Virgen Macarena | Sevilla, Spain, 41009
        • Hosp. de La Marina Baixa | Villajoyosa, Spain, 03570
        • Hosp. Univ. Miguel Servet | Zaragoza, Spain, 50009
        • China Medical University Hospital | Taichung, Taiwan, 40447
        • Taichung Veterans General Hospital | Taichung, Taiwan, 40705
        • National Taiwan University Hospital | Taipei City, Taiwan, 10002
        • Mackay Memorial Hospital | Taipei, Taiwan, 10449
        • Istanbul University | Istambul, Turkey, 34098
        • Ege University Medical Faculty | Izmir, Turkey, 35040
        • Mersin University Medical Faculty | Mersin, Turkey, 33343
        Investigators

          More Information

          Additional Relevant MeSH Terms

          • Colitis
          • Colitis, Ulcerative
          • Ulcer
          • Gastroenteritis
          • Gastrointestinal Diseases
          • Digestive System Diseases
          • Colonic Diseases
          • Intestinal Diseases
          • Pathologic Processes
          • Inflammatory Bowel Diseases