Surfactant Replacement Therapy
Publication Date: October 1, 2013
Last Updated: March 14, 2022
RECOMMENDATIONS
Administration of surfactant replacement therapy is strongly recommended in a clinical setting where properly trained personnel and equipment for intubation and resuscitation is readily available. (1 – StrongA)
679
Prophylactic surfactant administration is recommended for neonatal RDS in which surfactant deficiency is suspected. (1 – StrongB)
679
Rescue or therapeutic administration of surfactant after the initiation of mechanical ventilation in infants with clinically confirmed RDS is strongly recommended. (1 – StrongA)
679
A multiple surfactant dose strategy is recommended over a single dose strategy. (1 – StrongB)
679
Natural exogenous surfactant preparations are recommended over laboratory derived synthetic suspensions at this time. (1 – StrongB)
679
We suggest that aerosolized delivery of surfactant not be utilized at this time. (2 – WeakB)
679
Recommendation Grading
Overview
Title
Surfactant Replacement Therapy
Authoring Organization
American Association for Respiratory Care
Publication Month/Year
October 1, 2013
Last Updated Month/Year
September 13, 2023
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Document Objectives
Updated Clinical Practice Guideline on Surfactant Replacement Therapy
Target Patient Population
Infants with neonatal respiratory distress syndrome
Inclusion Criteria
Infant
Health Care Settings
Hospital
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Treatment
Diseases/Conditions (MeSH)
D011663 - Pulmonary Surfactants, D012127 - Respiratory Distress Syndrome, Newborn, D003696 - Delivery Rooms
Keywords
acute respiratory distress syndrome, prematurity, surfactant
Source Citation
Respir Care 2013;58(2):367–375
Supplemental Methodology Resources
Methodology
Number of Source Documents
90
Literature Search Start Date
January 1, 1990
Literature Search End Date
July 1, 2012