Stage III Non-Small Cell Lung Cancer
Key Points
Key Points
- Stage III non-small cell lung cancer (NSCLC) represents one of the most heterogenous subgroups of lung cancer. Consequently, it is also the subgroup in which choice and sequence of multimodality treatment varies significantly among clinicians, with variations being observed across and within institutes.
- This guideline reviews the published evidence addressing diagnosis and management of stage III NSCLC and provides evidence-based guidance on the common clinical dilemmas that clinicians may have while evaluating a patient with suspected or known stage III NSCLC.
- Four randomized control trials (RCTs) published in 2022, 2023, and 2024, prompted an amendment to the 2021 guideline.
Diagnosis
...gnosis...
...ation and Staging
...commendation 1.1For patients with s...
...ion 1.2Following evaluation with CT...
...1.3For patients with suspected stage II...
...ation 1.4For patients who require...
...mmendation 1.5For patients who require path...
...mmendation 1.6For patients who have suspected o...
...ctice PointBiopsy should generally be performed...
...urgery
...2.1For patients with stage IIIA (N2...
...ation 2.2For selected patients wit...
...ractice Points...
...tients with stage III NSCLC generally should n...
...oncogenic driver alterations, avai...
...ts and providers should consider enrollment on cli...
Treatment
...atment...
...uvant Therapy
...ommendation 3.1Patients who are planned...
...ion 3.2Patients with stage III NSCLC wh...
...mendation 3.3For patients with resectable sup...
...vant Therapy...
...on 4.1Patients with resected stage III NSCLC...
....2Patients with resected stage III NSCL...
...mmendation 4.3For patients with completely resec...
Unresectable Disea...
...ation 5.1Patients with stage III NSCLC who are m...
...n 5.2Concurrent chemotherapy delivered with r...
Recommendation 5.3Patients with stage III NSCLC...
...ation 5.4Patients with stage III NSCLC rece...
...ommendation 5.5Doses higher than 60 G...
...ation 5.6Patients with stage III NSC...
...5.7Patients with stage III NSCLC receiving co...
...5.8(Update): Patients with unresectable stage I...
...igure 1. Evaluation and Staging in Sta...
...gement of Stage III NSCLCArrows with dotted lin...