Title
The Care of the Patient with Amyotrophic Lateral Sclerosis: Drug, Nutritional, And Respiratory Therapies
Authoring Organization
Publication Month/Year
October 1, 2009
Last Updated Month/Year
October 17, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Document Objectives
To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS).
Target Patient Population
Patients with amyotrophic lateral sclerosis
PICO Questions
Does lithium carbonate prolong survival or slow disease progression in amyotrophic lateral sclerosis?
What is the effect of riluzole on slowing the disease process or prolonging survival in amyotrophic lateral sclerosis?
What is the effect of enteral nutrition administered via Percutaneous Endoscopic Gastrostomy on weight stability?
When is Percutaneous Endoscopic Gastrostomy indicated in amyotrophic lateral sclerosis?
What is the efficacy of nutritional support via Percutaneous Endoscopic Gastrostomy in prolonging survival?
What is the effect of enteral nutrition delivered via Percutaneous Endoscopic Gastrostomy on quality of life?
What is the efficacy of vitamin and nutritional supplements on prolonging survival or quality of life?
What are the optimal pulmonary tests to detect respiratory insufficiency?
Does Non-invasive ventilation improve respiratory function or increase survival?
How do invasive and noninvasive ventilation affect quality of life?
What factors influence acceptance of invasive and noninvasive ventilation?
What is the efficacy of targeted respiratory interventions for clearing secretions?
Inclusion Criteria
Male, Female, Adult
Health Care Settings
Ambulatory, Hospital, Outpatient
Intended Users
Dietician nutritionist, nurse, nurse practitioner, occupational therapist, physician, physician assistant, respiratory therapist
Scope
Assessment and screening, Treatment, Management
Diseases/Conditions (MeSH)
D000690 - Amyotrophic Lateral Sclerosis, D019636 - Neurodegenerative Diseases
Keywords
amyotrophic lateral sclerosis, neurodegenerative disease
Source Citation
Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. R. G. Miller, C. E. Jackson, E. J. Kasarskis, J. D. England, D. Forshew, W. Johnston, S. Kalra, J. S. Katz, H. Mitsumoto, J. Rosenfeld, C. Shoesmith, M. J. Strong, S. C. Woolley. Neurology Oct 2009, 73 (15) 1218-1226; DOI: 10.1212/WNL.0b013e3181bc0141