Title

Adverse Reactions to Vaccines

Authoring Organizations

Publication Month/Year

May 7, 2012

Last Updated Month/Year

October 17, 2024

Document Type

Guideline

Country of Publication

US

Document Objectives

This practice parameter provides a practical, peer-reviewed, evidence-based guide for evaluation and management of patients with suspected allergic or other adverse reactions to vaccines. It also addresses patients with preexisting allergies or other health conditions that might preclude or alter vaccination.  The practice parameter offers both general and vaccine-specific recommendations for (1) skin testing to vaccines and components, (2) serum specific IgE antibody testing, (3) serologic testing for protective antibody responses to vaccines, (4) vaccine administration, and (5) avoidance.

Target Provider Population

Specialists in allergy and immunology but also other physicians.

Inclusion Criteria

Male, Female, Adolescent, Adult, Child, Infant, Older adult

Health Care Settings

Ambulatory

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Management, Prevention

Keywords

vaccine reactions, adverse vaccine reactions

Source Citation

Kelso JM, Greenhawt MJ, Li JT, Nicklas RA, Bernstein DI, Blessing-Moore J, Cox L, Khan D, Lang DM, Oppenheimer J, Portnoy JM, Randolph CR, Schuller DE, Spector SL, Tilles SA, Wallace D. Adverse reactions to vaccines practice parameter 2012 update. J Allergy Clin Immunol. 2012 Jul;130(1):25-43. doi: 10.1016/j.jaci.2012.04.003. Epub 2012 May 16. PMID: 22608573.