Kawasaki Disease
Key Points
Key Points
- Kawasaki disease (KD) is a medium vessel vasculitis, one of two primary common vasculitis syndromes that predominantly affect children (the other being Henoch-Schönlein purpura/IgA vasculitis).
- KD typically presents in children under 5 years of age with an incidence in the US of 25–50/100,000, similar to that of type 1 diabetes.
- KD treated appropriately is associated with a low rate of mortality (approximately 0.08% case fatality rate in the largest series).
- However, in the developed world, KD is the most common cause of acquired cardiac disease in childhood, with 25% of untreated and 5% of treated cases developing coronary artery aneurysms.
- In infants less than 6 months of age, the risk of a coronary artery aneurysm is 50% even in KD patients treated with intravenous immunoglobulin (IVIG) within the first 10 days of illness.
- These recommendations provide guidance regarding diagnostic strategies, use of pharmacologic agents, and role of echocardiography for patients with suspected or confirmed KD.
Definitions and Medications
...ons and Medications...
...finitions for Selected Terms Used in the Recom...
Treatment and Diagnostic Testing
...and Diagnostic Testing
...iagnostic Testing and Treatment of Pat...
...e Statement: Intravenous immunoglobulin is the st...
...ith acute KD who are at high risk of IVIG res...
For patients with acute KD who are at high risk o...
...ts with incomplete KD, prompt treatment at tim...
...ts with acute KD and suspected or diagnosed...
...with acute KD and persistent fevers after initial...
...aded Position Statement: For patients with...
...ents with acute KD, using aspirin is...
...with acute KD with subsequent resolut...
...tients with acute KD with arthritis that pe...
...tional diagnostic testing recomme...
...th suspected incomplete KD and feve...
...with unexplained shock physiology, obtaining an...
...or children with unexplained macro...
.... Key Recommendations for the Treatment of KD...