Thromboprophylaxis in Patients with COVID-19
Publication Date: February 10, 2022
Last Updated: April 1, 2024
Summary of Recommendations
In acutely ill hospitalized patients with COVID-19 who have low risk of bleeding, with consideration for the remarks below, we suggest therapeutic dose heparin (UFH or LMWH) over current standard dose anticoagulant thromboprophylaxis (C, U)
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In acutely ill hospitalized patients with COVID-19 who are not receiving therapeutic dose heparin (UFH or LMWH), we recommend current standard dose anticoagulant thromboprophylaxis over intermediate dose anticoagulation (defined as LMWH BID or increased weight-based dosing that is less than recommended therapeutic doses) (S, U)
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In critically ill patients with COVID-19, we suggest current standard dose anticoagulant thromboprophylaxis (with UFH or LMWH) over therapeutic dose anticoagulation (C, U)
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In critically ill patients with COVID-19, we suggest current standard dose anticoagulant thromboprophylaxis over intermediate dose anticoagulation (defined as LMWH BID or increased weight-based dosing that is less than recommended therapeutic doses) (C, U)
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Recommendation Grading
Overview
Title
Thromboprophylaxis in Patients with COVID-19
Authoring Organization
American College of Chest Physicians
Publication Month/Year
February 10, 2022
Last Updated Month/Year
April 1, 2024
Supplemental Implementation Tools
Document Type
Guideline
Country of Publication
US
Inclusion Criteria
Male, Female, Adult, Older adult
Health Care Settings
Emergency care, Hospital
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Management, Prevention
Diseases/Conditions (MeSH)
D000086382 - COVID-19
Keywords
Coronavirus, covid-19, thromboprophylaxis, COVID
Source Citation
Moores LK, Tritschler T, Brosnahan S, Carrier M, Collen JF, Doerschug K, Holley AB, Iaccarino J, Jimenez D, LeGal G, Rali P, Wells P. Thromboprophylaxis in Patients with COVID-19. A Brief Update to the CHEST Guideline and Expert Panel Report. Chest. 2022 Feb 12:S0012-3692(22)00250-1. doi: 10.1016/j.chest.2022.02.006. Epub ahead of print. PMID: 35167861; PMCID: PMC8839802.