Secondary Prevention of Cervical Cancer

Publication Date: September 25, 2022

Key Points

Key Points

  • ASCO published its first guideline on secondary prevention of cervical cancer in 2016. This guideline updates the previous. New and altered recommendations for 2022 are identified; others remain the same as in 2016.
  • Resource stratified guidelines provide recommendations given the level of resources in particular settings.
  • Human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing is recommended in all resource settings; visual inspection with acetic acid may be used in the basic setting.
  • Women who are human immunodeficiency virus (HIV)-positive should be screened for HPV after diagnosis and twice as many times throughout their lifetime as those in the general population.

Resource Settings

...rce Settings...

...amework of Resource StratificationSetting...


Screening/Triage/Management

...ening/Triage/Management...

...aximal Setti...

...n 2022: In maximal resource settings, cervical c...

...≥65 years of age who have had cons...

If the results of the HPV DNA test are pos...

...s are abnormal (i.e., ≥ atypical squamou...

...est results are positive at the repeat 12-month f...

...ave received HPV and cytology co-testing triage...

...he results of the biopsy indicate tha...

...women receive treatment for precursor lesi...


...anced Setting...

...ew in 2022: In enhanced resource setti...

...there are two consecutive negative...

...men who are ≥65 years of age who have had consi...

...ts of the HPV DNA test are positive, clinicians...

...results are abnormal (i.e., ≥ASC-US or positiv...

...PV test results are positive at the...

...f colposcopy and biopsy indicate that women ha...

...eive treatment for precursor lesions, follow-up s...


Limited Set...

...2022: Cervical cancer screening wit...

...flex cytology (quality assured) an...

...l inspection with acetic acid (VIA). ( CB ,...

New in 2022: If cytology triage results are abnor...

...2022: If HPV genotyping or VIA or VAT tri...

...f test results are positive at the repeat 12...

For treatment, clinicians should o...

...ive treatment for precursor lesions, follow-...


...asic Setti...

New in 2022: Health systems in basi...

...f the results of available HPV testing are pos...

...2: If primary screening is VIA and results a...

...ter women receive treatment for precursor...


...1. VIA versus VAT...


...ure 2. Secondary Prevention of Cervical Cance...


...econdary Prevention of Cervical Cancer...


...ndary Prevention of Cervical Cancer for Women Age...


Figure 5. Secondary Prevention of Ce...


...ASCO believes that cancer clinical...