Secondary Prevention of Cervical Cancer

Publication Date: September 25, 2022

Key Points

Key Points

  • ASCO published its first guideline on secondary prevention of cervical cancer in 2016. This guideline updates the previous. New and altered recommendations for 2022 are identified; others remain the same as in 2016.
  • Resource stratified guidelines provide recommendations given the level of resources in particular settings.
  • Human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing is recommended in all resource settings; visual inspection with acetic acid may be used in the basic setting.
  • Women who are human immunodeficiency virus (HIV)-positive should be screened for HPV after diagnosis and twice as many times throughout their lifetime as those in the general population.

Resource Settings

Resource Setting...

...mework of Resource StratificationSettin...


Screening/Triage/Management

...ning/Triage/Manageme...

...al Setting...

...ew in 2022: In maximal resource settings, cerv...

...ho are ≥65 years of age who have had...

...esults of the HPV DNA test are positi...

...s are abnormal (i.e., ≥ atypical squa...

...esults are positive at the repeat 12-month foll...

...ho have received HPV and cytology co-testing tri...

...s of the biopsy indicate that women have precu...

...women receive treatment for precursor lesions, fo...


...anced Setting...

...enhanced resource settings, cervi...

If there are two consecutive negative scre...

...≥65 years of age who have had consist...

...results of the HPV DNA test are positive, clinic...

If triage results are abnormal (i.e., ≥ASC-US o...

...HPV test results are positive at the repea...

...sults of colposcopy and biopsy indicat...

...receive treatment for precursor lesions, follow...


...ited Setti...

...: Cervical cancer screening with HPV DNA testing...

...e with reflex cytology (quality assured) and/o...

...nspection with acetic acid (VIA). ( CB , , L ,...

...in 2022: If cytology triage results are abn...

...: If HPV genotyping or VIA or VAT...

...test results are positive at the repea...

...eatment, clinicians should offer ablation i...

...receive treatment for precursor le...


...asic Settin...

...w in 2022: Health systems in basic...

...2022: If the results of available H...

...primary screening is VIA and results are...

After women receive treatment for precu...


...1. VIA versus VAT...


...Secondary Prevention of Cervical Cancer for W...


...igure 3. Secondary Prevention of Ce...


...4. Secondary Prevention of Cervical Cancer f...


...igure 5. Secondary Prevention of Cervical Cancer f...


...ASCO believes that cancer clinical t...