Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women
Key Points
Key Points
- Preferred antibiotics for acute cystitis are nitrofurantoin, or trimethoprim-sulfamethoxazole (TMP-SMX) if local resistance rates are < 20%.
- In patients suspected of pyelonephritis, a urine culture and susceptibility testing should always be performed.
- Preferred antibiotics for outpatient pyelonephritis are a fluoroquinolone or TMP-SMX. Consider an initial single-dose IV ceftriaxone or an aminoglycoside if community resistance is > 10% or, for TMP-SMX, if susceptibility unknown.
- Women with pyelonephritis requiring hospitalization should be initially treated with an IV antimicrobial regimen such as a fluoroquinolone, an aminoglycoside with or without ampicillin, an extended-spectrum cephalosporin or extended-spectrum penicillin with or without an aminoglycoside, or a carbapenem.
Selecting a Treatment Regimen
...electing a Treatment Regimen
...Uncomplicated Cystitis...
...toin monohydrate/macrocrystals 100 mg bid for...
...-SMX DS bid for 3 days is an appropriate choice fo...
...of 20% as the resistance prevalence at w...
In some countries and regions, trimetho...
...osfomycin tromethamine 3 g single-dose is an...
...m 400 mg bid for 3 to 7 days is an...
...ighly efficacious. ( A , I )659...
...a propensity for collateral damage and should b...
...ts including amoxicillin-clavulanat...
...tams, such as cephalexin, are less well studied...
...actams generally have inferior efficacy and more a...
...59
...or ampicillin should NOT be used for...
...Pyelonephritis...
...suspected of pyelonephritis, a urine culture an...
...cin 500 mg bid for 7 days with or wi...
...e-time IV agent is utilized, a long-act...
...itial one-time IV dose of a long-acting p...
...consolidated 24-hour dose of an aminoglycosid...
...ily oral fluoroquinolone, including c...
...m-sulfamethoxazole (TMP-SMX) bid for 14...
...n initial IV dose of a long-acting parenter...
...a consolidated 24-hour dose of an aminoglyco...
...nephritis requiring hospitalization should be i...
...ted Urinary Tract Infections...
...ntibiotics for Acute Uncomplicated CystitisHaving...