Diagnosis and Treatment of Primary Adrenal Insufficiency
Diagnosis
Who Should Be Tested and How
Optimal Diagnostic Tests
Treatment
Treatment of Primary Adrenal Insufficiency in Adults
Glucocorticoid Replacement Regimen
Mineralocorticoid Replacement in PAI
Dehydroepiandrosterone Replacement
Treatment During Pregnancy
Treatment and Monitoring During Childhood
Management and Prevention of Adrenal Crisis in Patients with PAI
Additional Monitoring Requirement
Recommendation Grading
Overview
Title
Diagnosis and Treatment of Primary Adrenal Insufficiency
Authoring Organization
Endocrine Society
Endorsing Organization
Association for Diagnostics & Laboratory Medicine
Publication Month/Year
February 1, 2016
Last Updated Month/Year
April 3, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Inclusion Criteria
Female, Male, Adolescent, Adult, Child, Infant, Older adult
Health Care Settings
Ambulatory
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Assessment and screening, Diagnosis, Management, Treatment
Diseases/Conditions (MeSH)
D000309 - Adrenal Insufficiency
Keywords
primary adrenal insufficiency, PAI, hypocortisolism, Addison's disease
Source Citation
Stefan R. Bornstein, Bruno Allolio, Wiebke Arlt, Andreas Barthel, Andrew Don-Wauchope, Gary D. Hammer, Eystein S. Husebye, Deborah P. Merke, M. Hassan Murad, Constantine A. Stratakis, David J. Torpy, Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 101, Issue 2, 1 February 2016, Pages 364–389, https://doi.org/10.1210/jc.2015-1710