Cystic Fibrosis Colorectal Cancer Screening
Publication Date: December 28, 2017
Last Updated: March 14, 2022
Recommendation Statements
The CF Foundation recommends that all decisions on colorectal cancer screening and surveillance in individuals with CF be based on shared decisions between the provider and individual with CF about: treatment, comorbidities, safety, and quality of life.
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The CF Foundation recommends that all colorectal cancer screening and surveillance for individuals with CF are jointly managed by CF health care professionals and an endoscopist.
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The CF Foundation recommends colonoscopy as the screening examination for CRC in individuals with CF.
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The CF Foundation concludes that the evidence is insufficient to recommend the use of computed tomography colonography, stool-based tests, or flexible sigmoidoscopy in individuals with CF for the purpose of CRC screening.
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The CF Foundation recommends that CRC screening begin at age 40 y in individuals with CF with continued rescreening every 5 y.
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The CF Foundation recommends that individuals with CF who have undergone a colonoscopy that had any adenomatous polyps have surveillance colonoscopy in 3 y, unless a shorter interval is indicated by individual findings, with subsequent intervals based on the most recent endoscopic examination.
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The CF Foundation recommends that individuals with CF who are 30 years of age and older and have adequately recovered after receiving a solid organ transplantation begin CRC screening within 2 years of transplantation, except when they have had a negative colonoscopy within the past 5 y.
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The CF Foundation recommends continued CRC rescreening every 5 y in individuals with CF who have received a solid organ transplant.
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The CF Foundation recommends that individuals with CF who have undergone a solid organ transplantation and had colonoscopy that had any adenomatous polyps have surveillance colonoscopy in 3 years, unless a shorter interval is indicated by individual findings, with subsequent intervals based on the most recent endoscopic examination.
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The CF Foundation recommends that adults with CF undergoing a colonoscopy receive intensive regimens for bowel preparation to allow for optimal examination. The intensive regimen should include: 3-4 washes (minimum of 1 L purgative per wash) with the last wash occurring within 4-6 h before the examination.
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Recommendation Grading
Overview
Title
Cystic Fibrosis Colorectal Cancer Screening
Authoring Organization
Cystic Fibrosis Foundation
Publication Month/Year
December 28, 2017
Last Updated Month/Year
August 7, 2023
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Inclusion Criteria
Female, Male, Adolescent, Adult, Child, Infant
Health Care Settings
Hospital, Operating and recovery room, Outpatient
Intended Users
Social worker, epidemiology infection prevention, nurse, nurse practitioner, physician, physician assistant
Scope
Assessment and screening, Management
Diseases/Conditions (MeSH)
D015179 - Colorectal Neoplasms, D003550 - Cystic Fibrosis
Keywords
colorectal cancer, cystic fibrosis, colonoscopy, CFTR
Methodology
Number of Source Documents
51
Literature Search Start Date
February 1, 2016
Literature Search End Date
March 1, 2016