Title

Management of Post–Liver Transplant Biliary Strictures

Authoring Organization

American Society for Gastrointestinal Endoscopy

Publication Month/Year

February 13, 2023

Last Updated Month/Year

September 12, 2023

Supplemental Implementation Tools

Document Type

Guideline

Country of Publication

US

Document Objectives

This clinical practice guideline from the American Society for Gastrointestinal Endoscopy provides an evidence-based approach for strategies to manage biliary strictures in liver transplant recipients. This document was developed using the Grading of Recommendations Assessment, Development and Evaluation framework. The guideline addresses the role of ERCP versus percutaneous transhepatic biliary drainage and covered self-expanding metal stents (cSEMSs) versus multiple plastic stents for therapy of strictures, use of MRCP for diagnosing post-transplant biliary strictures, and administration of antibiotics versus no antibiotics during ERCP. In patients with post-transplant biliary strictures, we suggest ERCP as the initial intervention and cSEMSs as the preferred stent. In patients with unclear diagnosis or intermediate probability of a stricture, we suggest MRCP as the diagnostic modality. We suggest that antibiotics should be administered during ERCP when biliary drainage cannot be assured.

Inclusion Criteria

Adult, Older adult

Health Care Settings

Hospital, Outpatient, Operating and recovery room

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Management

Diseases/Conditions (MeSH)

D016031 - Liver Transplantation, D001659 - Biliary Tract

Keywords

ERCP, liver transplant, biliary, biliary strictures

Source Citation

Amateau SK, Kohli DR, Desai M, Chinnakotla S, Harrison ME, Chalhoub JM, Coelho-Prabhu N, Elhanafi SE, Forbes N, Fujii-Lau LL, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Thiruvengadam NR, Thosani NC, Qumseya BJ; (ASGE Standards of Practice Committee Chair). American Society for Gastrointestinal Endoscopy guideline on management of post-liver transplant biliary strictures: methodology and review of evidence. Gastrointest Endosc. 2023 Feb 8:S0016-5107(22)02032-6. doi: 10.1016/j.gie.2022.10.006. Epub ahead of print. PMID: 36792483.

Supplemental Methodology Resources

Systematic Review Document, Methodology Supplement