Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease
Publication Date: August 15, 2020
Key Points
Key Points
- Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world and is the fourth leading cause of death in the United States.
- To date, the only therapeutic interventions known to reduce mortality in COPD are smoking cessation and long-term treatment with continuous supplemental oxygen for patients who have severe hypoxemia at rest.
- Recently, interest in the use of noninvasive ventilation (NIV) in chronic hypercapnic COPD has been renewed with studies of so-called “high-intensity” NIV, which refers to inspiratory pressures higher than those used in most previous randomized controlled trials (RCTs) as well as controlled ventilation with higher-than-baseline respiratory rates to maximally reduce the PaCO2.
Treatment
...atment
...ith chronic (FEV1/FVC < 0.70 and resting P...
...TS suggests the use of nocturnal n...
...ATS suggests that patients with chronic sta...
...TS suggests NOT initiating long-term NIV during a...
...s NOT using an in-laboratory overnight...
...suggests NIV with targeted normalizatio...