Breast Cancer Germline Testing
Key Points
Key Points
- The advent of next-generation sequencing and multigene panel testing has changed the landscape of germline mutation testing with valuable implications for both prevention (particularly surgical) and treatment.
- However, the advent of expanded testing also presents challenges since the ease with which genes can be sequenced has outpaced the understanding of the clinical implications of the germline findings.
- This ASCO-SSO clinical practice guideline provides clinicians and other health care practitioners, nurses and social workers, patients, genetic counselors, and caregivers with formal consensus-based recommendations regarding the role of germline mutation testing in patients with breast cancer based on the best available evidence (Figure 1).
Treatment
Treatm...
...dation 1.1All patients newly diagnosed with b...
...commendation 1.2All patients newly diagnosed...
...ation 1.3Patients undergoing BRCA1/2 t...
...2.1All patients with recurrent breast ca...
...endation 2.2BRCA1/2 testing should...
....1All patients with a personal history of breast c...
Recommendation 3.2All patients with a personal hi...
...ion 4.1Testing for high penetrance genes b...
...mmendation 4.2Testing for moderate p...
...ion 4.3If a multi-gene panel is or...
...tion 5.1Patients undergoing geneti...
...ecommendation 5.2Patients with pathogenic var...
...endation 5.3Variants of uncertain significance sh...
....4Patients without a pathogenic variant on gen...
...Critical Elements of Pre- and Post-test Cou...
...al Comprehensive Cancer Network® (NCCN®) Princip...
...Germline Testing in Patients with Br...