Treatment of Central Disorders of Hypersomnolence
Publication Date: April 22, 2021
Last Updated: March 14, 2022
ADULT PATIENTS WITH NARCOLEPSY
1. We recommend that clinicians use modafinil for the treatment of narcolepsy in adults. (Strong)
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2. We recommend that clinicians use pitolisant for the treatment of narcolepsy in adults. (Strong)
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3. We recommend that clinicians use sodium oxybate for the treatment of narcolepsy in adults. (Strong)
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4. We recommend that clinicians use solriamfetol for the treatment of narcolepsy in adults. (Strong)
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5. We suggest that clinicians use armodafinil for the treatment of narcolepsy in adults. (Conditional)
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6. We suggest that clinicians use dextroamphetamine for the treatment of narcolepsy in adults. (Conditional)
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7. We suggest that clinicians use methylphenidate for the treatment of narcolepsy in adults. (Conditional)
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ADULT PATIENTS WITH IDIOPATHIC HYPERSOMNIA
8. We recommend that clinicians use modafinil for the treatment of idiopathic hypersomnia in adults. (Strong)
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9. We suggest that clinicians use clarithromycin for the treatment of idiopathic hypersomnia in adults. (Conditional)
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10. We suggest that clinicians use methylphenidate for the treatment of idiopathic hypersomnia in adults. (Conditional)
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11. We suggest that clinicians use pitolisant for the treatment of idiopathic hypersomnia in adults. (Conditional)
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12. We suggest that clinicians use sodium oxybate for the treatment of idiopathic hypersomnia in adults. (Conditional)
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ADULT PATIENTS WITH KLEINE-LEVIN SYNDROME
13. We suggest that clinicians use lithium for the treatment of Kleine-Levin syndrome in adults. (Conditional)
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ADULT PATIENTS WITH HYPERSOMNIA DUE TO MEDICAL CONDITIONS
HYPERSOMNIA SECONDARY TO ALPHA-SYNUCLEINOPATHIES
14. We suggest that clinicians use armodafinil for the treatment of hypersomnia secondary to dementia with Lewy bodies in adults. (Conditional)
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15. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to Parkinson’s disease in adults. (Conditional)
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16. We suggest that clinicians use sodium oxybate for the treatment of hypersomnia secondary to Parkinson’s disease in adults. (Conditional)
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POSTTRAUMATIC HYPERSOMNIA
17. We suggest that clinicians use armodafinil for the treatment of hypersomnia secondary to traumatic brain injury in adults. (Conditional)
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18. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to traumatic brain injury in adults. (Conditional)
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ADULT PATIENTS WITH GENETIC DISORDERS ASSOCIATED WITH PRIMARY CENTRAL NERVOUS SYSTEM SOMNOLENCE
19. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to myotonic dystrophy in adults. (Conditional)
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ADULT PATIENTS WITH HYPERSOMNIA SECONDARY TO BRAIN TUMORS, INFECTIONS, OR OTHER CENTRAL NERVOUS SYSTEM LESIONS
20. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to multiple sclerosis in adults. (Conditional)
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PEDIATRIC PATIENTS WITH NARCOLEPSY
21. We suggest that clinicians use modafinil for the treatment of narcolepsy in pediatric patients. (Conditional)
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22. We suggest that clinicians use sodium oxybate for the treatment of narcolepsy in pediatric patients. (Conditional)
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Recommendation Grading
Overview
Title
Treatment of Central Disorders of Hypersomnolence
Authoring Organization
American Academy of Sleep Medicine
Publication Month/Year
April 22, 2021
Last Updated Month/Year
April 1, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Inclusion Criteria
Male, Female, Adult, Older adult
Health Care Settings
Ambulatory, Hospital, Outpatient
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Treatment
Diseases/Conditions (MeSH)
D020177 - Idiopathic Hypersomnia
Keywords
hypersomnolence, narcolepsy, kleine-Levin Syndrome, hypersomnia, posttraumaric hypersomnia, Idiopathic hypersomnia