Title
Management of Pregnancy and Delivery in Congenital Fibrinogen Disorders
Authoring Organization
Publication Month/Year
January 22, 2024
Last Updated Month/Year
February 19, 2024
Supplemental Implementation Tools
Document Type
Consensus
Country of Publication
Global
Document Objectives
Congenital fibrinogen disorders (CFDs) are a heterogeneous group of rare congenital quantitative and / or qualitative fibrinogen deficiency. The spectrum of molecular anomalies is broad, leading to several subtypes of fibrinogen disorders (i.e., afibrinogenemia, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia). Pregnancy in women with CFDs is a high-risk clinical situation, with an increased tendency to miscarriages, bleeding, and thrombosis. Even though it is well established that management of such pregnancies requires a multidisciplinary approach involving specialists (hematologists and maternal / fetal medicine experts with expertise in the management of inherited bleeding disorders), specific guidelines are lacking. In this ISTH SSC communication, we aim to propose an expert consensus opinion with literature evidence where available on the strategy for management of pregnancy, delivery, and puerperium in CFDs.
Inclusion Criteria
Female, Adult
Health Care Settings
Ambulatory, Hospital, Outpatient
Intended Users
Nurse, nurse midwife, nurse practitioner, physician, physician assistant
Scope
Assessment and screening, Management
Diseases/Conditions (MeSH)
D000347 - Afibrinogenemia
Keywords
pregnancy, afibrinogenemia, Fibrinogen Deficiency, fibrinogen, Hypofibrinogenemia
Source Citation
Casini A, Kadir RA, Abdelwahab M, Manco-Johnson MJ, Raut S, Ross C, de Moerloose P, Santoro C, Acharya S, Management of pregnancy and delivery in congenital fibrinogen disorders: Communication from the ISTH SSC Subcommittee on Factor XIII and Fibrinogen, Journal of Thrombosis and Haemostasis (2024), doi: https://doi.org/10.1016/j.jtha.2024.01.008