Title
Vitamin D for the Prevention of Disease
Authoring Organization
Publication Month/Year
June 3, 2024
Last Updated Month/Year
October 23, 2024
Supplemental Implementation Tools
Document Type
Guideline
Country of Publication
US
Document Objectives
To develop clinical guidelines for the use of vitamin D (cholecalciferol [vitamin D3] or ergocalciferol [vitamin D2]) to lower the risk of disease in individuals without established indications for vitamin D treatment or 25(OH)D testing.
Target Patient Population
Patients who are being considered for vitamin D supplementation
PICO Questions
Should empiric vitamin D supplementation vs no empiric vitamin D supplementation be used for children and adolescents (ages 1 to 18 years)?
Should empiric vitamin D supplementation vs no empiric vitamin D supplementation be used for nonpregnant adults < 50 years of age?
Should vitamin D supplementation vs no vitamin D supplementation be used for nonpregnant adults < 50 years of age only when 25(OH)D levels are below a threshold?
Should empiric vitamin D supplementation vs no empiric vitamin D supplementation be used for adults aged 50 to 74 years?
Should vitamin D supplementation vs no vitamin D supplementation be used for adults aged 50 to 74 years only when 25(OH)D levels are below a threshold?
Should empiric vitamin D supplementation vs no empiric vitamin D supplementation be used by adults aged ≥ 75 years?
Should vitamin D supplementation vs no vitamin D supplementation be used by adults aged ≥ 75 years only when 25(OH)D levels are below a threshold?
Should empiric vitamin D supplementation vs no empiric vitamin D supplementation be used during pregnancy?
Should vitamin D supplementation vs no vitamin D supplementation be used during pregnancy only when 25(OH)D levels are below a threshold?
Should empiric vitamin D supplementation vs no empiric vitamin D supplementation be used for adults with prediabetes (by glycemic criteria)?
Should a daily, lower-dose vitamin D vs nondaily (ie, intermittent), higher-dose vitamin D be used for nonpregnant people for whom vitamin D treatment is indicated?
Should screening with a 25(OH)D test (with vitamin D supplementation/treatment only if below a threshold) vs no screening with a 25(OH)D test be used for healthy adults?
Should screening with a 25(OH)D test (with vitamin D supplementation/treatment only if below a threshold) vs no screening with a 25(OH)D test be used for adults with dark complexion?
hould screening with a 25(OH)D test (with vitamin D supplementation/treatment only if below a threshold) vs no screening with a 25(OH)D test be used for adults with obesity?
Inclusion Criteria
Male, Female, Adolescent, Adult, Child, Older adult
Intended Users
Dietician nutritionist, nurse, nurse midwife, nurse practitioner, physician, physician assistant
Scope
Prevention
Diseases/Conditions (MeSH)
D009765 - Obesity, D003920 - Diabetes Mellitus, D011247 - Pregnancy, D014808 - Vitamin D Deficiency, D011236 - Prediabetic State, D012279 - Rickets
Keywords
obesity, diabetes, diabetes mellitus, vitamin D, pregnancy, prediabetes, Vitamin D deficiency, 25-hydroxyvitamin D, cholecalciferol, ergocalciferol, vitamin D3, vitamin D2, 25(OH)D, rickets, respiratory tract infection
Source Citation
Demay MB, Pittas AG, Bikle DD, et al. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2024