Vitamin D for Disease Prevention

Publication Date: June 3, 2024

Key Points

Key Points

  • Numerous studies demonstrate an association between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety of common disorders including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, and infectious diseases. This has led to widespread supplementation with vitamin D supplementation and increased laboratory testing for 25(OH)D in the general population.
  • The benefit-risk ratio of this increase in vitamin D supplementation is not clear, and the optimal vitamin D intake and serum 25(OH)D concentrations for disease prevention remain uncertain.
  • This guideline offers clinical guidelines for the use of vitamin D (cholecalciferol [vitamin D3] or ergocalciferol [vitamin D2]) to lower the risk of disease in individuals without established indications for vitamin D treatment or 25(OH) D testing.

Treatment

Treatme...

...hildren Ages 1–18 Years...

...mendation 1...

...en and adolescents ages 1–18 year...


...gnant Adults...

...ommendation 2

...general adult population younger th...

...ommendation...

...general adult population younger t...


...ults Aged 50–74 Years

...ommendation...

...al population ages 50 to 74 years, we suggest agai...

...mendation 5

...opulation ages 50 to 74 years, we sug...


...dults Aged ≥75 Ye...

...mendation 6...

...population ages 75 years and older,...

Recommendati...

...the general population ages 75 years and o...


...egnancy...

Recommendati...

...ggest empiric vitamin D supplementat...

...mendation 9...

...ring pregnancy, we suggest against ro...


...Prediabetes (By Glycemic Criteria...

...ommendation 10...

...with high-risk prediabetes, in addition to lif...


...osing

...mmendation 11...

...50 years and older who have indications for vit...


...lthy Adults

...commendation 1...

...ts, we suggest against routine screening for 25...


...with Dark Complexion...

...ecommendatio...

...dark complexion, we suggest against rou...


...dults with Obesi...

...commendation 14...

...n adults with obesity, we suggest a...