Germline Genetic Testing for Cancer
Key Points
Key Points
- Family history plays an important role in informing appropriate gene selection for germline testing.
- The number of genes available on germline panels varies widely, ranging from a few to more than a hundred.
- It is important to recognize that tumor testing is not a substitute for germline testing. Therefore, any individual meeting the criteria for germline genetic testing should still undergo clinical genetic testing optimized for detection of germline variants, regardless of the tumor profiling results.
Diagnosis
...agnosi...
...amily History Colle...
...n 1.1All patients should have a family his...
...endation 1.2 Patients should be...
...ne Multi-gene Panel Te...
...ion 2.1When germline genetic testing is indicate...
...tion 2.2When considering what to order for m...
...mline Multi-gene Panel Test...
...ommendation 3If germline multi-gene panel testing...
...e Included in Multi-gene Panels...
...ion 4.1Patients who meet criteria for germline ge...
...ecommendation 4.2Regardless of germline...
...ecommended for Testing and Inclusion in Mu...
...Genes for Which Pathogenic Variants Identified v...
...Tumors Relevant to Each Gene if a Con...
... Figure 1. Selection of Genes for Multi...
...gure 2. Germline Testing in Response to Tu...
ASCO believes that cancer clinical trials are...