Treatment of Congenital Hemophilia A and B

Publication Date: June 19, 2024

Key Points

Key Points

  • Hemophilia is a congenital X-linked bleeding disorder that affects an estimated 1,125,000 individuals worldwide, 80% of whom have hemophilia A.
  • Individuals with severe (and some moderate) forms of hemophilia not treated with prophylaxis may experience spontaneous bleeding, of which the most frequent are joint and muscle bleeding.
  • Prophylaxis rather than episodic treatment is strongly recommended for severe and moderately-severe hemophilia A and B.

Treatment

Treatment

...A Without Inhibitors...

...individuals with severe and moderat...

...iduals with severe and moderately-severe hemophi...

In individuals with severe and moderately...

...mited settings in which the use of standard-...

...viously untreated individuals with severe hem...

...viduals with severe and moderately-severe...


...lia A With Inhibitors...

...n individuals with severe hemophilia A with inh...

...with severe hemophilia A with inhib...

...with severe hemophilia A with high-responding inhi...

...uals with severe hemophilia A with inhi...

...ls with severe hemophilia A with inhibit...


...lia B Without Inhibitors...

...dividuals with severe and moderatel...

...dividuals with severe and moderately-severe hemo...