Systemic Therapy for Stage I–III Anal Squamous Cell Carcinoma
Publication Date: December 16, 2024
Key Points
Key Points
- Anal and anorectal cancers are relatively rare, yet age-adjusted death rates rose an average 5.1% each year from 2013 to 2022.a
- Most cases are linked to human papillomavirus (HPV) infection, and risk factors include human immunodeficiency virus (HIV) infection and smoking.
- For many decades, definitive CRT has been the standard of care in anal cancer.
a National Cancer Institute: Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Anal Cancer, 2024.
Treatment
...eatment
...e: The following recommendations (strong or co...
...ion 1: What are the recommended radiosensiti...
...n-C (MMC) with a fluoropyrimidine (5-fluorouracil...
...in with 5FU is an additional chemothera...
...n 2: What are the recommended dose and sch...
....Recommended dosing and schedules for the chem...
...here combination chemotherapy is not indicated,...
...on 3: Is induction chemotherapy recommend...
....Routine induction chemotherapy prior to...
...on 4: Is ongoing adjuvant chemotherapy reco...
....Additional chemotherapy following CRT is...
...nal Cancer Algorithma Due to an increased risk o...