Title
Management of Cancer Cachexia
Authoring Organization
Publication Month/Year
July 12, 2023
Last Updated Month/Year
September 30, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Document Objectives
In 2020, ASCO published a guideline on the management of cancer cachexia in adults with advanced cancer. Evidence was insufficient to strongly endorse any pharmacologic agent, but recommendations supported clinicians in offering a short-term trial of a progesterone analog or corticosteroid to patients experiencing loss of weight and/or appetite. The Expert Panel discussed a potential role for olanzapine but concluded that the evidence was insufficient for a recommendation. The publication of a 2023 randomized controlled trial (RCT) of olanzapine prompted the Expert Panel to revisit this topic.
Target Patient Population
Adult patients with advanced cancer and loss of appetite, body weight, and/or lean body mass (ie, skeletal muscle).
Target Provider Population
Clinicians who provide care to adult patients with cancer, as well as patients and caregivers.
Inclusion Criteria
Male, Female, Adult, Older adult
Health Care Settings
Ambulatory, Home health, Hospital, Long term care
Intended Users
Dietician nutritionist, nurse, nurse practitioner, health systems pharmacist, physician, physician assistant, social worker
Scope
Treatment, Management
Diseases/Conditions (MeSH)
D002100 - Cachexia
Keywords
cancer, Cancer Cachexia, nutritional interventions, pharmacological interventions, precachexia, refractory cachexia, cachexia
Source Citation
Eric J. Roeland, MD; Kari Bohlke, ScD; Vickie E. Baracos, PhD; Management of Cancer Cachexia: ASCO Guideline update. J Clin Oncol. 2023 July 12. doi: 10.1200/JCO.23.01280
Eric J. Roeland, MD; Kari Bohlke, ScD; Vickie E. Baracos, PhD; Eduardo Bruera, MD; Egidio del Fabbro, MD; Suzanne Dixon, MPH, MS, RD; Marie Fallon, MD; Jørn Herrstedt, MD, DMSci; Harold Lau, MD; Mary Platek, PhD, MS, RD; Hope S. Rugo, MD; Hester H. Schnipper, LICSW; Thomas J Smith, MD; Winston Tan, MD; Charles L. Loprinzi, MD. Management of Cancer Cachexia: ASCO Guideline. J Clin Oncol. 2020 May 20 doi: 10.1200/JCO.20.00611