Obesity

Publication Date: January 2, 2015

Key Points

Key Points

  • The Task Force agrees with the opinion of prominent medical societies that current scientific evidence supports the view that obesity is a disease.
  • Weight loss produces many benefits including risk factor improvement, prevention of disease, and improvements in feeling and function. Greater weight loss produces greater benefits, but modest (5%–10%) weight loss, such as that produced by lifestyle modifications and medications, has been shown to produce significant improvements in many conditions.
  • Medications used for the management of conditions other than obesity can contribute to or exacerbate weight gain in susceptible individuals. Many of these conditions are also associated with obesity.
  • Health care providers can help patients prevent or attenuate weight gain by appropriately prescribing medications that would promote weight loss or minimize weight gain when treating these conditions.
  • Health care providers can help selected patients successfully lose weight and maintain lost weight by appropriately prescribing weight loss medications or in some cases surgical intervention as an adjunct to lifestyle change.

Diagnosis

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...2. Comorbid Conditions in Obesity and Evidence for...


Treatment

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...o promote long-term weight maintenance, ES sugges...


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...ests assessment of efficacy and safety at leas...


...nt’s response to a weight loss medicat...


...n for chronic obesity management is prescribed as...


...ts with T2DM who are overweight or obese, ES su...


...n patients with CVD who seek pharmacological tre...


...Weight Gain and Some Alternatives...

...ecommends weight-losing and weight-neutral...

...patients with T2DM requiring insulin ther...

...mmends ACE inhibitors, angiotensin rec...

...hen antidepressant therapy is indicated, ES...

...ing weight-neutral antipsychotic alternatives...

...ecommends considering weight gain potential i...

...a BMI >27 kg/m2 with comorbidities or >3...

...s monitoring the weight and waist circumferenc...

...e use of NSAIDs and disease-modifying...

...suggests the use of antihistamines...


...of Drugs Approved for Other Indications...

...suggests against the off-label use of medications...


...3. Drugs Associated with Weight Gain and S...


...ntages and Disadvantages Associated wit...


...acotherapy for Obesity in the United StatesHa...