Paget's Disease of Bone
Key Points
Key Points
- Paget’s disease of bone (osteitis deformans) is a chronic benign disorder of bone that generally affects one or several bones.
- The abnormal bone structure may be associated with enlarged affected bones and skeletal deformity, particularly in weight-bearing bones.
- Many patients with Paget’s disease of bone are asymptomatic. Bone pain, mild to moderate in intensity and described as deep and aching, is a feature of Paget’s disease of bone, usually developing late rather than early in the disease process, and it is only present in a minority of patients.
- The clinical features and complications of Paget’s disease are closely related, but presentation varies from patient to patient.
- The most common neurological complication of Paget’s disease is hearing loss associated with disease involving the skull.
- Studies of patients with Paget’s disease indicate there is a family history of the disorder, an autosomal dominant transmission pattern, in 5%–40%, with most researchers reporting a 10%–20% incidence.
- Paget’s disease affects both men and women, with an apparent small male predominance. It rarely manifests itself clinically before age 40, and the frequency of the condition increases with advancing age.
- Rates in the United States are estimated to be approximately 2%–3% among individuals older than 55 years.
Diagnosis
...agnosi...
Imaging
...patients with suspected Paget’s disease,...
...patients diagnosed with Paget’s disease, the...
...ochemistr...
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...toms and Complications of Paget’s Dis...
Treatment
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...ndication...
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...a single 5-mg dose of IV zoledronate as...
...sessing the Response to Treatmen...
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...suggests that patients who have osteolytic...
...intaining Remissi...
...suggests that to maximize the duration of re...
...and Retreatment...
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...tic Paget’s Disease
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...lysis...
...f paraplegia associated with Paget’s d...
...eoplasms
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...treatment with a bisphosphonate in pat...