Paget's Disease of Bone
Key Points
Key Points
- Paget’s disease of bone (osteitis deformans) is a chronic benign disorder of bone that generally affects one or several bones.
- The abnormal bone structure may be associated with enlarged affected bones and skeletal deformity, particularly in weight-bearing bones.
- Many patients with Paget’s disease of bone are asymptomatic. Bone pain, mild to moderate in intensity and described as deep and aching, is a feature of Paget’s disease of bone, usually developing late rather than early in the disease process, and it is only present in a minority of patients.
- The clinical features and complications of Paget’s disease are closely related, but presentation varies from patient to patient.
- The most common neurological complication of Paget’s disease is hearing loss associated with disease involving the skull.
- Studies of patients with Paget’s disease indicate there is a family history of the disorder, an autosomal dominant transmission pattern, in 5%–40%, with most researchers reporting a 10%–20% incidence.
- Paget’s disease affects both men and women, with an apparent small male predominance. It rarely manifests itself clinically before age 40, and the frequency of the condition increases with advancing age.
- Rates in the United States are estimated to be approximately 2%–3% among individuals older than 55 years.
Diagnosis
...iagnosis...
Imagin...
...s with suspected Paget’s disease,...
...diagnosed with Paget’s disease,...
...chemistr...
...recommends that after radiological d...
...s measuring a specific marker of bone formati...
...oms and Complications of Paget’s Disease of...
Treatment
...atment...
...2. Recommended Bisphosphonate Dosing RegimensHavi...
Indication...
...recommends treatment with a bisphosphona...
...ice of Medication...
...s a single 5-mg dose of IV zoledrona...
...ssing the Response to Treatme...
...rgency in the control of symptoms or the...
The ES suggests that patients who have oste...
Maintaining Rem...
...S suggests that to maximize the duratio...
...pse and Retreatmen...
...S recommends that in patients with inc...
...ostotic Paget’s Diseas...
...uggests that amino-terminal propeptide of type 1...
...of the Complications of Paget’s Disease...
...ring Loss...
...ES suggests treatment with a potent bisphos...
...eoarthritis...
...s the use of analgesics as adjunctive therapy fo...
...ients with severe osteoarthritis adjace...
...wing of Lower Extremit...
...suggests treatment with a potent bisphosphonate...
...lysis...
...of paraplegia associated with Paget’s dis...
...plasms...
...ggests that patients with osteosarco...
...gestive Heart Fai...
...ES suggests treatment with a bisphosphona...