ANCA-Associated Vasculitis
Publication Date: July 7, 2021
Key Points
Key Points
- Common clinical manifestations of granulomatosis with polyangiitis (GPA) include destructive sino-nasal lesions, pulmonary nodules, and pauci-immune glomerulonephritis.
- GPA is characterized histologically by necrotizing, granulomatous inflammation in addition to vasculitis.
- Common clinical manifestations of microscopic polyangiitis (MPA) include rapidly progressive pauci-immune glomerulonephritis and alveolar hemorrhage.
- MPA is characterized histologically by vasculitis without granulomatous inflammation.
- Common clinical manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) include asthma, peripheral eosinophilia, and peripheral neuropathy.
- EGPA is characterized histologically by eosinophilic tissue infiltration in addition to vasculitis.
Definitions and Treatments
...nitions and Treatme...
...e 1. Definitions for GPA, MPA, EGP...
...le 2. Quality of Evidence and Strength...
Recommendations
...mmendations...
...eatments: GPA, MPA, EGPAHaving trouble viewi...
...le 4. Recommendations: GPA or MPAHav...
...Key Recommendations for the Treatment...
.... Recommendations: EGPAHaving trouble v...
...igure 2. Key Recommendations for the Treatment of...