Acute Hematogenous Osteomyelitis
Key Points
Key Points
- Acute hematogenous osteomyelitis (AHO) occurs when bacteria enter and proliferate within the cellular and extracellular matrix of bone, generally accompanied by a host inflammatory response.
- The incidence of AHO in children ranges from 1.2 to 13 cases per 100,000 children per year
- Most of the cases involve a single bone, but about 5% involve multiple bones.
- The presentation of AHO varies from well-localized infection over a single metaphysis with a minimal associated systemic inflammatory response to multifocal infection with septic shock.
- Fever and pain are the most common manifestations of bone infection.
Surveillance and Remediation
...nce and Remediation Acute osteomyelitis is de...
Diagnosis
...agnosis...
Laboratory T...
...ith suspected AHO, we recommend performing...
...n children with suspected AHO, we suggest p...
...ith suspected AHO, we suggest against using seru...
...iagnosis Infection of adjacent soft tiss...
...res In children with suspected AHO, we suggest...
...magin...
...hildren with suspected AHO, we recommend obta...
...hildren with suspected AHO requiring fu...
Treatment
...atment...
...Antimicrobial Therapy...
...h presumed AHO who are ill-appearing...
...en with presumed AHO who are not clinically ill...
...with suspected AHO, we recommend usi...
...Parenteral and Oral Therapy...
...dren with confirmed AHO, selection of...
...ren with suspected AHO without an identified bact...
...en with AHO requiring a surgical procedure, we r...
...Therapeutic Procedur...
...children with AHO who present with sepsis or hav...
...AHO who is clinically stable but is docum...
...ss the ResponseIn children with suspected or co...
...charge Planning...
...children with suspected or documented AHO who resp...
...children with suspected or documented...
...of AntibioticsIn children with AHO presu...
...d-of-Therapy Im...
...nd against obtaining end-of-therapy MRI...
...suggest against routine end-of-therapy...
...with complicated AHO or with involvement of the p...
...esponse or Relapse...
...r children either experiencing pri...
...cians should reassess the need for surgic...
...Follow-upIn children with AHO who are deter...
...otic Choice and Duration of Therapy for Unc...
...2. Antibiotic Dosages for Pediatric Acute He...