Use of Endocrine Therapy for Breast Cancer Risk Reduction

Publication Date: September 3, 2019

Introduction

Introduction

This guideline is relevant to women without a personal history of breast cancer (BC) who are at increased risk of developing the disease.

Diagnosis

Diagno...

...ble 1. Breast Cancer Risk Assessment...


Treatment

...eatment...

...mary of All Recommendations...

...oxifen

...iscussed as an option to reduce the r...

...recommended for use in women with a histo...

Is NOT recommended for women who are pregnant,...

...OT recommended in combination with ho...

...uld include a timely work-up of abnormal vagin...

...ssions with patients and health care providers...

.../d orally for 5 years. (EB, S)72...

...ng evidence-based on 5 RCTs with low ris...

Raloxifene

...iscussed as an option to reduce the risk of...

...used longer than 5 years in women with osteopo...

...be used for BC risk reduction in p...

...ommended for use in women with a history o...

...ns with patients and health care providers shou...

...GE: 60 mg/d orally for 5 years. (...

...-based on 4 RCTs with low risk of bias)...

Exemesta...

...discussed as an alternative to tamoxifen...

...hould NOT be used for BC risk reduction i...

...s with patients and health care provider...

...25 mg/d orally for 5 years. (EB, M)7...

...vidence-based on 1 RCT with low risk of b...

...strozole...

...g/day orally for 5 years) should be discussed...

...en most likely to benefit are those with o...

...d NOT prescribe anastrozole, exemestane or...

...ons between patients and health care provider...

Prior to initiating an aromatase inhibitor, clinic...

...ns should inform women also of the possibility of...

...tweigh harms; Evidence quality: high...


...ry of Agent IndicationsHaving trouble viewin...


...e Effects of Endocrine TherapyHaving trouble vi...