Systemic Therapy for Melanoma
Key Points
Key Points
- The clinical burden associated with the treatment of melanoma has been increasing due to rising incidence globally.
- Since 2011, 12 new drugs have been approved for unresectable melanoma and 4 additional drugs have been approved in the adjuvant setting.
- Overall survival for melanoma is improving rapidly, with dramatic increases in long-term survival observed from administration of these new therapies.
- This guideline includes recommendations on uveal melanoma based on new clinical trial data.
Treatment
Treatment
...vant Systemic Thera...
...eous Melanoma Eligible for R...
....1.Neoadjuvant pembrolizumab (maxim...
....2.Patients with clinical and rese...
...djuvant Systemic Thera...
...(Stage II, III, IV) Cutaneous Melanoma...
...ndation 2.1.1.Adjuvant pembrolizumab...
...on 2.1.2.Adjuvant therapy should not b...
...ndation 2.2.For patients with resected stage IIIA...
Recommendation 2.3.For patients with r...
...commendation 2.4.No recommendation can be made...
...ndation 2.5.1.Patients with resected st...
...ecommendation 2.5....
...ab alone ( IC , M, , W )3336...
...ivolumab plus ipilimumab followed by nivo...
...mab alone ( IC , L , , W )3336...
...ib plus trametinib (in patients with BRAF...
...c Therapy Options...
...nresectable/Metastatic Cutaneous...
...ommendation 3.1.For patients with B...
...ecommendation 3.2.1.For patients with BRAF mutant...
...endation 3.2.2....
...nation therapy with nivolumab plus ipilimu...
...ion therapy with nivolumab plus ipil...
...mendation 3.3.After progression on anti-...
...mendation 3.4.After progression on 1st...
...3.5.For patients with injectable (cutaneous or su...
...-Cutaneous Melanoma (Stage II or Gre...
...4.1.1.HLA-A*02:01-positive patients with metasta...
...tion 4.1.2.For all patients with uveal melanoma ot...
...4.2.In the absence of further data, the co...
Recommendation 4.3.No recommendation...
...sonable Dose and Schedule Details for Recommended...
...nable Dose and Schedule Details for Recommende...
...gure 1. Systemic Therapy for Melanom...
...ure 1. Systemic Therapy for Melanoma (cont&#...