Systemic Therapy for Melanoma
Key Points
Key Points
- The clinical burden associated with the treatment of melanoma has been increasing due to rising incidence globally.
- Since 2011, 12 new drugs have been approved for unresectable melanoma and 4 additional drugs have been approved in the adjuvant setting.
- Overall survival for melanoma is improving rapidly, with dramatic increases in long-term survival observed from administration of these new therapies.
- This guideline includes recommendations on uveal melanoma based on new clinical trial data.
Treatment
...eatmen...
...adjuvant Systemic T...
...anoma Eligible for Resection...
...tion 1.1.Neoadjuvant pembrolizumab (...
...ation 1.2.Patients with clinical and rese...
...vant Systemic Therapy
...(Stage II, III, IV) Cutaneous Melanoma...
Recommendation 2.1.1.Adjuvant pembrolizumab...
...tion 2.1.2.Adjuvant therapy should not be offe...
...ommendation 2.2.For patients with r...
...on 2.3.For patients with resected stage IIIAâ...
....4.No recommendation can be made for or agai...
...2.5.1.Patients with resected stage IV mela...
...commendation 2.5....
...lone ( IC , M, , W )3336...
...plus ipilimumab followed by nivolu...
...izumab alone ( IC , L , , W...
...enib plus trametinib (in patients w...
...mic Therapy Options...
...etastatic Cutaneous Melanoma...
...ecommendation 3.1.For patients with BRA...
Recommendation 3.2.1.For patients with BRA...
...ndation 3.2.2.
...ination therapy with nivolumab plus ipilimumab is...
...ation therapy with nivolumab plus i...
Recommendation 3.3.After progressio...
...tion 3.4.After progression on 1st li...
...ion 3.5.For patients with injectable (cutaneous...
...us Melanoma (Stage II or Greater)...
...ommendation 4.1.1.HLA-A*02:01-positive patients w...
...dation 4.1.2.For all patients with uveal melanoma...
...ion 4.2.In the absence of further data, the co...
...endation 4.3.No recommendation for...
...ble 1. Reasonable Dose and Schedule Details f...
...able 2. Reasonable Dose and Schedule De...
...igure 1. Systemic Therapy for Melan...
...Systemic Therapy for Melanoma (cont'd)...