Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

Publication Date: February 27, 2019

Key Points

Key Points

Although anatomically adjacent to one another, accumulating data suggests that, in many ways, squamous cell carcinoma of oral cavity (SCCOC) and oropharynx (SCCOP) may be distinct diseases from a biological perspective.

Oral SCC is predominately associated with tobacco and betel nut use. On the other hand, SCCOP is increasing in incidence in recent decades due to chronic latent infections of the human papillomavirus (HPV) and appears to disproportionately affect younger people.

The majority of patients with SCCOP have node-positive (cN+) necks at presentation, and 10-40% of patients without cN+ necks at presentation will have occult nodal metastases in both SCCOC and SCCOP. As such, management of the neck is a critical component of high quality oncologic care of these patients.

Treatment

...atment

...al Cavity

...patients with oral cavity SCC classified as cT...

For patients with oral cavity SCC classi...

...with a cN0 neck, an ipsilateral elective n...

...h a cN+ contralateral neck, a cont...

An ipsilateral therapeutic selective ne...

...juvant neck radiotherapy should NOT be administer...

...t neck radiotherapy should be administered to pati...

...radiotherapy should be administer...

...vant chemoradiotherapy using intrav...

...t weekly cisplatin may be administered wit...

Elective neck dissection is the pref...

...s who have undergone ipsilateral neck...


...pharynx...

...lateralized oropharyngeal carcinoma w...

...with lateralized oropharyngeal cancer...

...nts with tumors extending to the midli...

...urgical approach should be offered to patients...

...th biopsy-proven distant metastase...

.../CT scan at ≥12 weeks after completion of r...

...ts who complete radiation/chemorad...

.../CT scan at ≥12 weeks shows mild FDG uptake i...


...Treatment Algorithm for Management of the...


...atment Algorithm for Management of the N...