Management of Hereditary Breast Cancer
Key Points
Key Points
- The integration of genomics into the care of oncology patients has led to an increasing population of breast cancer patients identified with germline (i.e., inherited) mutations in breast cancer susceptibility genes, requiring physicians to integrate this information into treatment decision-making.
- Pathogenic or likely pathogenic variants (commonly referred to as mutations) in high-penetrance breast cancer susceptibility genes increase the risk of breast cancer more than 4-fold.
- Germline mutations in BRCA1 or BRCA2 (BRCA1/2) are found in 3–4% of all women with breast cancer, including 10–20% of those with triple negative breast cancer and 10–15% of Jewish women with breast cancer.
- The lifetime risk of breast cancer for a BRCA mutation carrier varies from 50–90% based on populations studied, gene, study design and method of analysis.
- Other high-penetrance breast cancer susceptibility genes include PTEN (Cowden's Syndrome), TP53 (Li-Fraumeni Syndrome), STK11 (Peutz-Jeghers Syndrome), and CDH1 (Hereditary Invasive Lobular Breast-Diffuse Gastric Cancer).
- Mutations in more moderate-penetrance genes such as PALB2, CHEK2, and ATM occur in 4–6% of breast cancer patients with lifetime risk of 35%–60% (PALB2) and 25%–30% (ATM and CHEK2).
- Providers caring for breast cancer patients with germline BRCA1/2 mutations should discuss treatment options related to the index cancer and the increased risk of contralateral breast and new ipsilateral breast cancer.
Management
...agement...
Recommendation 1.1Germline BRCA status should not...
...ion 1.2Surgical management of the inde...
...mendation 1.3The following factors s...
...mendation 1.4BRCA1/2 mutation carri...
...mmendation 2.1For women with newly diagnosed breas...
...ion 2.2In breast cancer patients with a mutat...
...dation 2.3The evidence regarding contralateral br...
Recommendation 2.4Patients with mutation...
...dation 3.1For women with newly diagnosed breast ca...
...mmendation 3.2For women with newly diagnosed b...
...ommendation 4.1For women with breast cancer who...
Recommendation 4.2For women with breast...
...ation 5.1For breast cancer patients with a del...
Recommendation 5.2For breast cancer pa...
...endation 6.1For women with breast cancer w...
...commendation 6.2For women with breast...
...ecommendation 6.3For women with breast ca...
...on 7When offering chemotherapy for germ...
...8For germline BRCA mutation carriers...
...mmendation 9.1For BRCA1/2 mutation car...
...dation 9.2For breast cancer patients with...
...dation 10 – ASCO Recommendation Upda...
.... Management of Hereditary Breast Can...
...t Cancer Who Have a BRCA1 or BRCA2 Mutati...
...Therapy Recommendations...
...dex/Current Cancer Germline BRCA status should...
...ction/Second cancer The following...
...Therapy Recommendations...
...ring chemotherapy for germline BRCA muta...
... with Breast Cancer Who Have a Mutation in a...
...ocal Therapy Recommenda...
...ancer For women with newly diagnosed breast canc...
...uction/Second Cancer For women with breast c...
...herapy Recommendations...
...For breast cancer patients with m...
...linical Stage + Pathologic Stage + ER status + Nuc...