Role of Immunotherapy in In Vitro Fertilization
Publication Date: August 1, 2018
Last Updated: March 14, 2022
Recommendatons
Given the lack of evidence to support improved IVF outcomes, there is good evidence to recommend against the routine use of low-dose aspirin to improve the outcome of live birth in ART cycles in the general population. (A)
331071
There is good evidence to recommend against the routine use of corticosteroids during stimulation to improve the outcome of live birth in ART cycles in the general population. (A)
331071
There is good evidence to recommend against the routine use of corticosteroids during the implantation window to improve the outcome of live birth in ART cycles in the general population. (A)
331071
There is insufficient evidence to recommend for or against local G-CSF to improve endometrial thickness in women with thin endometrium or clinical pregnancy rates with IVF. (C)
331071
There is insufficient evidence to recommend for or against G-CSF or GM-CSF administered locally or systemically to improve IVF outcomes. (C)
331071
There is insufficient evidence to routinely recommend intravenous fat emulsions for infertile women pursuing IVF. (C)
331071
There is insufficient evidence to recommend IVIG administration as part of IVF to improve IVF outcomes. (C)
331071
There is insufficient evidence to recommend adalimumab treatment to improve IVF outcome. (C)
331071
There is insufficient evidence to recommend intrauterine infusion of autologous peripheral mononuclear cells prior to ET to improve IVF outcome. (C)
331071
There is fair evidence that seminal plasma insemination as part of IVF improves clinical pregnancy rate. (B)
331071
However, there is fair evidence that it does not improve ongoing pregnancy or live-birth rates.
(B)331071
There is insufficient evidence to support the recommendation either for or against antibody-free preparation of spermatozoa in improving IVF outcomes. (C)
This procedure has been rendered obsolete by the use of ICSI.
331071
There is insufficient evidence to recommend tacrolimus to improve IVF-ET outcome. (C)
331071
Recommendation Grading
Overview
Title
Role of Immunotherapy in In Vitro Fertilization
Authoring Organization
American Society for Reproductive Medicine
Publication Month/Year
August 1, 2018
Last Updated Month/Year
January 23, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Document Objectives
The purpose of this guideline is to evaluate the role of immunomodulating therapy in ART
Target Patient Population
Patients with infertility
Inclusion Criteria
Female, Male, Adult
Health Care Settings
Ambulatory, Laboratory services, Outpatient
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Management
Diseases/Conditions (MeSH)
D007246 - Infertility, D007167 - Immunotherapy, D007136 - Immunoglobulins, D016179 - Granulocyte Colony-Stimulating Factor, D000068879 - Adalimumab
Keywords
immunotherapy, adalimumab, infertility, ivig
Source Citation
Fertility and Sterility® Vol. 110, No. 3, August 2018 0015-0282