Surgical Treatment of Patients With Lynch Syndrome

Publication Date: February 1, 2017
Last Updated: March 14, 2022

Recommendations

MANAGEMENT

For individuals with Lynch syndrome who develop a colon cancer, a total colectomy is preferred for cancer risk reduction. (1B)
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Patients with Lynch syndrome who develop a colon cancer may consider segmental colectomy despite the inferior cancer risk reduction because of differences in bowel function between segmental and total colectomy. (2C)
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Annual colonoscopy should be performed after segmental resection of colon cancer in patients with Lynch syndrome. (1B)
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For patients with Lynch syndrome and rectal cancer, the rectal cancer should be treated based on standard oncologic principles, as in sporadic rectal cancer. The decision for concomitant colectomy may be considered on a selective basis. (2C)
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Hysterectomy and bilateral salpingo-oophorectomy should be offered to women with Lynch syndrome undergoing colectomy, particularly if they have finished childbearing. (1B)
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Recommendation Grading

Overview

Title

Surgical Treatment of Patients With Lynch Syndrome

Authoring Organization

American Society of Colon and Rectal Surgeons

Publication Month/Year

February 1, 2017

Last Updated Month/Year

January 17, 2024

Supplemental Implementation Tools

Document Type

Guideline

External Publication Status

Published

Country of Publication

US

Inclusion Criteria

Female, Male, Adolescent, Adult, Child, Infant, Older adult

Health Care Settings

Emergency care, Hospital, Operating and recovery room

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Counseling, Assessment and screening, Treatment

Diseases/Conditions (MeSH)

D055847 - Lynch Syndrome II, D003110 - Colonic Neoplasms

Keywords

Lynch syndrome, colorectal neoplasm, hereditary nonpolyposis colon cancer

Source Citation

Herzig, D. O., Buie, W. D., Weiser, M. R., You, Y. N., Rafferty, J. F., Feingold, D., & Steele, S. R. (2017). Clinical Practice Guidelines for the Surgical Treatment of Patients With Lynch Syndrome. Diseases of the Colon & Rectum, 60(2), 137–143. doi:10.1097/dcr.0000000000000785