High dose glucocorticoids for treatment of postoperative pain: A systematic review of the literature and meta-analysis. Journal Abstract

High dose glucocorticoids for treatment of postoperative pain: A systematic review of the literature and meta-analysis.

Publication Date: 2024 May

Full Text Sources

Elsevier Science (Free)

ClinicalKey (Free)

Authors

Giulia Laconi; Steve Coppens; Eva Roofthooft; Marc Van De Velde

Abstract

OBJECTIVE

Glucocorticoids as a component of multimodal analgesia have been studied for many years and their post-operative analgesic effects appear to be dose-dependent. We conducted a systematic review of randomized controlled trials (RCTs) to evaluate the evidence of peri-operative high dose corticosteroid therapy in comparison to placebo (placebo drug) or control group (no treatment) for improving the quality of post-operative analgesia as indicated by a reduction of 10 mm in 100 mm Visual Analogue Scale (VAS) or reduction of 1 point in a 0-10 point VAS scale, or a reduction of 1 point in an 11-point Numerical Rating Scale (NRS) score, or reduction of rescue opioid analgesia, in patients undergoing all types of surgery.

Source

Journal of clinical anesthesia

Pub Types(s)

Systematic Review

Language

English

PubMed ID

38091865