Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Journal Abstract

Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock.

Publication Date: 2024 Jun 01

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Authors

Mihir R Atreya; Tellen D Bennett; Alon Geva; E Vincent S Faustino; Colin M Rogerson; Riad Lutfi; Natalie Z Cvijanovich; Michael T Bigham; Jeffrey Nowak; Adam J Schwarz; Torrey Baines; Bereketeab Haileselassie; Neal J Thomas; Yuan Luo; L Nelson Sanchez-Pinto

Abstract

OBJECTIVE

Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven "persistent hypoxemia, encephalopathy, and shock" (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk strata.

Source

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Pub Types(s)

Journal Article

Language

English

PubMed ID

38465952