Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study. Journal Abstract

Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.

Publication Date: 2024 Jun

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Authors

Neil Chanchlani; Simeng Lin; Claire Bewshea; Benjamin Hamilton; Amanda Thomas; Rebecca Smith; Christopher Roberts; Maria Bishara; Rachel Nice; Charlie W Lees; Shaji Sebastian; Peter M Irving; Richard K Russell; Timothy J McDonald; James R Goodhand; Tariq Ahmad; Nicholas A Kennedy

Abstract

OBJECTIVE

We sought to report the effectiveness of infliximab and adalimumab over the first 3 years of treatment and to define the factors that predict anti-TNF treatment failure and the strategies that prevent or mitigate loss of response.

Source

The lancet. Gastroenterology & hepatology

Pub Types(s)

Journal Article

Language

English

PubMed ID

38640937