Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial. Journal Abstract

Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.

Publication Date: 2024 Aug 06

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Authors

Lorraine B Ware; D Clark Files; Alpha Fowler; Michael S Aboodi; Neil R Aggarwal; Roy G Brower; Steven Y Chang; Ivor S Douglas; Scott Fields; Andrea S Foulkes; Adit A Ginde; Estelle S Harris; Gregory W Hendey; R Duncan Hite; Weixing Huang; Poying Lai; Kathleen D Liu; B Taylor Thompson; Michael A Matthay

Abstract

OBJECTIVE

Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates.

Source

JAMA

Pub Types(s)

Clinical Trial, Phase II

Language

English

PubMed ID

38762798