The complexities of T-cell dysfunction in chronic lymphocytic leukemia. Journal Abstract

The complexities of T-cell dysfunction in chronic lymphocytic leukemia.

Publication Date: 2024 Jun

Full Text Sources

Elsevier Science (Free)

ClinicalKey (Free)

Authors

Elena Camerini; Derk Amsen; Arnon P Kater; Fleur S Peters

Abstract

OBJECTIVE

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by profound alterations and defects in the T-cell compartment. This observation has gained renewed interest as T-cell treatment strategies, which are successfully applied in more aggressive B-cell malignancies, have yielded disappointing results in CLL. Despite ongoing efforts to understand and address the observed T-cell defects, the exact mechanisms and nature underlying this dysfunction remain largely unknown. In this review, we examine the supporting signals from T cells to CLL cells in the lymph node niche, summarize key findings on T-cell functional defects, delve into potential underlying causes, and explore novel strategies for reversing these deficiencies. Our goal is to identify strategies aimed at resolving CLL-induced T-cell dysfunction which, in the future, will enhance the efficacy of autologous T-cell-based therapies for CLL patients.

Source

Seminars in hematology

Pub Types(s)

Journal Article

Language

English

PubMed ID

38782635