Early-Stage Breast Cancer: A Critical Review of Current and Emerging Practice. Journal Abstract

Early-Stage Breast Cancer: A Critical Review of Current and Emerging Practice.

Publication Date: 2024 Dec 01

Full Text Sources

Elsevier Science (Free)

ClinicalKey (Free)

Authors

Danielle Rodin; Rachel M Glicksman; Jaroslaw T Hepel; Kathryn Huber; Youlia Kirova; Pierre Loap; Eileen Rakovitch

Abstract

OBJECTIVE

Breast-conserving surgery followed by adjuvant radiation to reduce the risk of ipsilateral breast tumor recurrence is the mainstay of treatment for early-stage breast cancer (ESBC). However, improved understanding of the heterogeneity of the clinical and molecular characteristics of ESBC has led to greater efforts to personalize approaches to treatment. Furthermore, advances in the understanding of the radiobiology of breast cancer have led to several practice-changing trials on the effectiveness and tolerability of moderate and ultrahypofractionated radiation. Here, we review the recent evidence and ongoing research in the radiotherapeutic management of ESBC, including the use of boost for high-risk disease and opportunities for accelerated fractionation, partial breast irradiation, and radiation omission for low-risk disease. We also discuss how molecular profiling can inform decision-making and new opportunities for primary radiation therapy and reirradiation.

Source

International journal of radiation oncology, biology, physics

Pub Types(s)

Journal Article

Language

English

PubMed ID

39237044