Title

Pharmacological Management of Irritable Bowel Syndrome

Authoring Organization

American Gastroenterological Association

Publication Month/Year

November 2, 2014

Last Updated Month/Year

November 6, 2024

Document Type

Guideline

External Publication Status

Published

Country of Publication

US

Document Objectives

This document presents the official recommendations of the American Gastroenterological Association (AGA) on the use of pharmacological agents for the treatment of irritable bowel syndrome (IBS) in adults.

Target Patient Population

Adults with irritable bowel syndrome (IBS)

PICO Questions

  1. Should Linaclotide Be Used in Patients With IBS-C?

  2. Should Lubiprostone Be Used in Patients With IBS-C?

  3. Should PEG Laxatives Be Used in Patients With IBS-C?

  4. Should Rifaximin Be Used in Patients With IBS-D?

  5. Should Alosetron Be Used in Patients With IBS-D?

  6. Should Loperamide Be Used in Patients With IBS-D?

  7. Should Tricyclic Antidepressants Be Used in Patients With IBS?

  8. Should Selective Serotonin Reuptake Inhibitors Be Used in Patients With IBS?

  9. Should Antispasmodics Be Used in Patients With IBS?

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Ambulatory

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Treatment, Management

Diseases/Conditions (MeSH)

D043183 - Irritable Bowel Syndrome

Keywords

irritable bowel syndrome (IBS), IBS-D, IBS, IBS-C, irritable bowel syndrome with diarrhea, irritable bowel syndrome with constipation

Source Citation

Weinberg DS, Smalley W, Heidelbaugh JJ, Sultan S. American Gastroenterological Association Institute Guideline on the Pharmacological Management of Irritable Bowel Syndrome. Gastroenterology 2014;147:1146–1148.

Supplemental Methodology Resources

Technical Review