Use of Intravenous tPA for the Management of Acute Ischemic Stroke in the Emergency Department
Recommendations
Patient Management
Recommendation Grading
Grade of Evidence | ||
Grade | Recommendation | Description |
A | Strong | A preponderance of level I and/or level II studies supports the recommendation, This must include at least 1 level I study. |
B | Moderate | A single high-quality randomized controlled trial or a preponderance of level II evidence supports the recommendation. |
C | Weak | A single level II study or a preponderance of level II and TV studies supports the recommendation. |
D | Conflicting | Higher-quality studies conducted on this topic disagree with respect to their conclusions. The recommendation is based on these conflicting studies. |
E | Theoretical/foundational | A preponderance of evidence from animal or cadaver studies, from conceptual models/principles or from basic science/bench research supports this conclusion. |
F | Expert opinion | Best practice based on the clinical experience of the guidelines development team. |
Overview
Title
Use of Intravenous tPA for the Management of Acute Ischemic Stroke in the Emergency Department
Authoring Organization
American College of Emergency Physicians
Publication Month/Year
September 1, 2015
Last Updated Month/Year
January 10, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Document Objectives
This clinical policy from the American College of Emergency Physicians is the revision of a clinical policy approved in 2012 addressing critical questions in the evaluation and management of patients with acute ischemic stroke
Target Patient Population
Patients with acute ischemic stroke
Inclusion Criteria
Female, Male, Adolescent, Adult, Older adult
Health Care Settings
Emergency care
Intended Users
Paramedic emt, nurse, nurse practitioner, physician, physician assistant
Scope
Assessment and screening, Management, Treatment
Diseases/Conditions (MeSH)
D020521 - Stroke, D002545 - Brain Ischemia, D010960 - Plasminogen Activators, D010959 - Tissue Plasminogen Activator
Keywords
Acute Ischemic Stroke, t-pa, plasminogen activator
Source Citation
Ann Emerg Med. 2015;66:322-333.