Nonpharmacologic Versus Pharmacologic Treatment Of Adult Patients With Major Depressive Disorder

Publication Date: March 1, 2016
Last Updated: March 14, 2022

Recommendation

ACP recommends that clinicians select between either cognitive behavioral therapy or second-generation antidepressants to treat patients with major depressive disorder after discussing treatment effects, adverse effect profiles, cost, accessibility, and preferences with the patient. (Moderate, Strong)
317067

Recommendation Grading

Overview

Title

Nonpharmacologic Versus Pharmacologic Treatment Of Adult Patients With Major Depressive Disorder

Authoring Organization

American College of Physicians

Publication Month/Year

March 1, 2016

Last Updated Month/Year

August 1, 2023

Supplemental Implementation Tools

Document Type

Guideline

External Publication Status

Published

Country of Publication

US

Document Objectives

The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the comparative effectiveness of treatment with second-generation antidepressants versus nonpharmacologic treatments for major depressive disorder in adults.

Target Patient Population

Patients with major depressive disorder

Inclusion Criteria

Female, Male, Adolescent, Adult, Older adult

Health Care Settings

Ambulatory, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Assessment and screening, Management, Treatment

Diseases/Conditions (MeSH)

D000928 - Antidepressive Agents, D018687 - Antidepressive Agents, Second-Generation, D011613 - Psychotherapy

Keywords

nonpharmacological treatment, depression, antidepressants, Antidepressants, major depressive disorder

Methodology

Number of Source Documents
71
Literature Search Start Date
January 1, 1990
Literature Search End Date
September 1, 2015