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Clinical Practice Guidelines

Guidelines Spotlight Patients Hospitalized with Heart Failure

2024 ACC Expert Consensus Decision Pathway on Clinical Assessment, Management, and Trajectory of Patients Hospitalized With Heart Failure Focused Update – Guidelines Spotlight

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Updated Content from the 2019 ECDP Patients Hospitalized with Heart Failure In August 2024, the American College of Cardiology (ACC) published a focused update on the  Clinical Assessment, Management, and Trajectory of Patients Hospitalized With Heart Failure that harmonizes their 2019 ACC ECDP with the 2022 ACC/AHA Heart Failure guidelines to provide updated recommendations regarding […]

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What's Changed Uncomplicated Urinary Tract Infections (UTIs) in Women

Uncomplicated Urinary Tract Infections in Women – What’s Changed

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Patients with uncomplicated urinary tract infections (UTIs) do not have any structural abnormalities in their urinary tract or comorbidities such as diabetes, an immunocompromised state, recent urologic surgery, or pregnancy. An uncomplicated UTI is also referred to as cystitis or a lower tract UTI. It is estimated that approximately half of all women will experience […]

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Medical Legal Rundown

Medical Legal Rundown (August 2024)

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In this new series, we bring you the latest news stories that illustrate the complex intersections between healthcare and the legal system. From medical malpractice and patient rights to bioethics and regulatory challenges, we delve into how these two critical fields collide and interact. Join us as we navigate the multifaceted relationship between medicine and […]

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ASCO’s Prostate Cancer Guidelines are Now Open for Public Comment

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The American Society of Clinical Oncology (ASCO) has announced that the following guidelines, “Systemic Therapy in Men with Metastatic Castration-Resistant Prostate Cancer: ASCO Guideline Update” and “Germline and Somatic Genomic Testing in Metastatic Prostate Cancer: ASCO Guideline” are now open for public comment.  The Metastatic Castration-Resistant Prostate Cancer Guideline, is an update to ASCO’s 2014 […]

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Guidelines + Journal Rundown Oncology Hematology Oncology

Top Oncology / Hematology Articles – Guidelines+ Journals Rundown

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In this post, we will be taking a closer look at some of the most popular oncology / hematology-related articles recently published across medical journals. Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, EGFR–Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer First-Line Nivolumab Plus Relatlimab Versus Nivolumab Plus […]

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AGA’s Hepatitis B Virus Reactivation Guideline is Now Open for Public Comment

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The American Gastroenterological Association (AGA) has announced that their latest guideline, the “AGA Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation in Immunosuppressed Individuals” is now open for public comment. This guideline, aimed at educating and providing guidance to frontline health practitioners on the prevention and management of Hepatitis B virus reactivation […]

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ISTH Int'l Guidelines

The International Society on Thrombosis and Haemostasis (ISTH) – Guidelines International Series

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In our latest installment of the Guidelines International Series, we will be looking at the latest guidelines from the International Society on Thrombosis and Haemostasis (ISTH). As the leading global organization in the field of bleeding and clotting disorders, ISTH plays a pivotal role in offering healthcare professionals and researchers worldwide with invaluable educational resources, […]

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What's Changed & Predictions Gout

Gout – What’s Changed Since+ Predictions

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Gout is a common medical condition characterized by the accumulation of monosodium urate (MSU) monohydrate crystals in the tissues, often resulting in painful flares that can last for one to two weeks. According to the National Institutes of Health (NIH), gout is more prevalent in men than in women and typically presents in middle age. […]

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Guidelines Timeline - AAO Dry Eye Syndrome

Comparing the AAO Dry Eye Syndrome Preferred Practice Pattern – Guidelines Timeline

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The American Academy of Ophthalmology (AAO) is the largest association of eye physicians and surgeons globally. Their mission is to protect vision and enhance quality of life by establishing the benchmarks for ophthalmic education and championing the interests of patients and the general public.   AAO regularly releases Preferred Practice Pattern® guidelines (PPP) aimed at defining […]

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Guidelines Side-By-Side Bariatric Surgery

Comparing Bariatric Surgery Guidelines – Guidelines Side-By-Side

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Affecting more than one-third of adults in the US, obesity remains a pressing health challenge for both providers and patients, conferring significant risk for comorbidities such as type 2 diabetes, obstructive sleep apnea, and cardiovascular disease. While lifestyle modifications and medical therapies, including anti-obesity medications (AOM), can be effective for some, they often fall short […]

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Dapagliflozin (Farxiga/AZ) – Guidelines+ Monographs (August 2024 Edition)

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In this edition of our Guidelines Monographs Series, we will be taking a look at AstraZeneca’s medication dapagliflozin, brand name Farxiga. Initially approved in 2014, Farxiga is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, provided to individuals with diabetes, heart disease, or kidney disease to improve their outcomes. This Guidelines+ Monograph will take a deeper dive […]

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Guidelines+ Trials Spotlight - ITRAILBLAZER-ALZ 2

TRAILBLAZER-ALZ 2 Topline Results for the Treatment of Alzheimer’s Disease – Guidelines+ Trials Spotlight

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On July 2, 2024, the US Food and Drug Administration (FDA) granted approval for Eli Lilly’s Kisunla (donanemab-azbt) injection for the treatment of Alzheimer’s disease. This treatment is recommended for patients in the early stages of the disease, specifically those with mild cognitive impairment or mild dementia, as demonstrated in the clinical trials. Kisunla marks […]

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What's Changed & Predictions Hyperlipidemia

Pharmacological Management for Hyperlipidemia – What’s Changed Since+ Predictions

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High cholesterol, also known as hyperlipidemia, affects millions of individuals in the United States (US). This condition can lead to serious health issues, such as an increased risk of heart disease and stroke. Globally, approximately one-third of cases of ischaemic heart disease are linked to high cholesterol levels. Elevated total cholesterol is a significant contributor […]

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Guidelines Spotlight Immunization Schedules for Adults and Children

Immunization Schedules for Adults and Children – Guidelines Spotlight (National Immunization Awareness Month)

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As we prepare for the National Immunization Awareness Month 2024 and upcoming autumn season, we will be conducting a thorough review of the United States Immunization Schedules for both Adults and Children. These crucial recommendations are released annually by the Centers for Disease Control and Prevention (CDC). They offer essential guidance on the recommended schedules […]

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Guidelines + Journal Rundown Sleep Medicine

Top Sleep Medicine Articles – Guidelines+ Journals Rundown

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In this post, we will be taking a closer look at some of the most popular sleep medicine-related articles recently published across medical journals. Longer-term effect of physical activity intervention on sleep quality: a secondary analysis of cluster randomized controlled trial Delayed school start time is associated with better sleep, mental health, and life satisfaction […]

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What's Changed Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA) – What’s Changed?

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation primarily affecting the synovial joints. This condition arises from an aberrant immune response targeting the synovium, leading to persistent inflammation, joint damage, and potential systemic manifestations. If left untreated, RA can cause significant damage to the joints and surrounding tissues, potentially leading to […]

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AAN’s Migraine Prevention Guideline is Now Open for Public Comment

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The American Academy of Neurology (AAN) has announced that their latest guideline, “Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Update: Report of the AAN Guidelines Subcommittee,” is now open for public comment. This practice guideline offers updated evidence-based conclusions and recommendations on the use of pharmacologic migraine prevention in adults. The primary objective […]

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Guidelines Timeline - AGS Beers Criteria

Comparing the American Geriatrics Society (AGS) Beers Criteria – Guidelines Timeline

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The American Geriatrics Society (AGS) Beers Criteria® for Potentially Inappropriate Medication (PIM) Use in Older Adults is a widely recognized and utilized tool in the healthcare community. The AGS Beers Criteria is regularly updated every 3-4 years to ensure its relevance and accuracy in guiding healthcare professionals in prescribing medications for individuals aged 65 and […]

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Guidelines Rundown - Breastfeeding

Breastfeeding – Guidelines Rundown (National Breastfeeding Month 2024)

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Our Guidelines Rundown Series continues with a new article that delves into the topic of breastfeeding in support of National Breastfeeding Month 2024. To provide guidance and clinical decision-making support on the matter, the Academy of Breastfeeding Medicine has published a comprehensive set of guidelines that address various aspects of breastfeeding, such as nutrition, supplements, […]

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What's Changed & Predictions Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy – What’s Changed Since+ Predictions Series

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Duchenne Muscular Dystrophy (DMD) is a severe inherited neuromuscular disorder caused by mutations in the dystrophin gene. It leads to progressive muscle wasting and irreversible functional decline. Primarily affecting males due to X-linked recessive inheritance, DMD can also rarely affect females. Symptoms include gradual muscle atrophy and fibrous tissue replacement in skeletal and cardiac muscles. […]

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What's Changed & Predictions Thyroid Eye Disease (TED)

Thyroid Eye Disease (TED) – What’s Changed Since+ Predictions

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Thyroid eye disease (TED), also known as Graves’ orbitopathy, is a complex immune-mediated disorder characterized by the aberrant proliferation of orbital fibroblasts, adipogenesis, glycosaminoglycan and mucin deposition. This connective tissue remodeling results in edematous, fibrotic adipose tissue and inflammation within the orbit and underlies the consequential classic presentation of proptosis, where the eyes appear pushed […]

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Guidelines Side-By-Side Obesity Rx

Anti-Obesity Medications – Guidelines Side-By-Side

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Obesity remains a pervasive health challenge affecting a significant portion of the population worldwide, with implications extending beyond physical appearance to encompass profound metabolic and cardiovascular risks. As medical understanding evolves, the focus on effective weight management strategies has intensified, supported by advancements in pharmacotherapy.  As recommendations and anti-obesity medications (AOM) pharmacotherapies evolve, understanding the […]

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Upcoming FDA Approvals & Decisions

Upcoming FDA Decisions – August 2024

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The Food and Drug Administration (FDA) protects public health by guaranteeing the safety, effectiveness, and security of pharmaceuticals and medical devices. The Prescription Drug User Fee Act (PDUFA) date marks the deadline by which the FDA must complete its review of drug applications. Occasionally, an advisory committee (AdCom) meeting is convened to assess the drug […]

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Guidelines + Journal Rundown: Primary Care & Family Practice

Top Primary Care & Family Medicine: Guidelines+ Journals Rundown

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In this post, we will be taking a closer look at some of the most popular primary care/family medicine-related articles recently published across medical journals. Morbidity and Mortality of Hospital-Onset SARS-CoV-2 Infections Due to Omicron Versus Prior Variants: A Propensity-Matched Analysis Is Prediabetes Overdiagnosed? Yes: A Patient-Epidemiologist’s Experience Is Prediabetes Overdiagnosed? No: A Clinician’s Perspective […]

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What's Changed & Predictions Treatment of Patients With Schizophrenia

Treatment of Patients With Schizophrenia – What’s Changed Since+ Predictions Series

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Among the top 10 causes of disability worldwide, schizophrenia’s relatively low prevalence is starkly contrasted by its profound impact on functional capacity and quality of life. With the National Institute of Mental Health estimating its prevalence in the US to range between 0.25% and 0.64%, schizophrenia is a disproportionately significant contributor to the global burden […]

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